Abstract:
:The CD4 subset of cells displays helper/inducer activity and recognizes class II antigens of the major histocompatibility complex (MHC), while the CD8 subset recognizes class I MHC antigens and exhibits cytotoxic or suppressor function. Considerable functional as well as corresponding phenotypic heterogeneity exists within the two major T cell subsets. Although the CD8+ population contains pre-cytotoxic, cytotoxic, pre-suppressor and suppressor effector T cells, these distinctions still rest largely on the use of functional assays. Attempts have been made to define the CD8+ precursor of the killer cell with new monoclonal antibodies. But more precise phenotypic distinctions between the functional subpopulations within CD8+ cells will be needed. We have now developed a monoclonal antibody, anti-S6F1 which can distinguish killer effector and suppressor effector cells in CD8 lymphocyte populations. The cell-surface structure defined by this antibody comprises two glycoproteins with relative molecular mass (Mr) 180K and 95K respectively. Also sequential immunoprecipitation studies and two dimensional gel electrophoresis indicate that anti-S6F1 recognizes a novel epitope on the LFA-1 antigen.
journal_name
Naturejournal_title
Natureauthors
Morimoto C,Rudd CE,Letvin NL,Schlossman SFdoi
10.1038/330479a0subject
Has Abstractpub_date
1987-12-03 00:00:00pages
479-82issue
6147eissn
0028-0836issn
1476-4687journal_volume
330pub_type
杂志文章相关文献
NATURE文献大全abstract::Recognition of self-antigen-derived epitopes presented by major histocompatibility complex class II (MHC II) molecules on thymic epithelial cells (TECs) is critical for the generation of a functional and self-tolerant CD4 T-cell repertoire. Whereas haematopoietic antigen-presenting cells generate MHC-II-peptide comple...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07208
更新日期:2008-09-18 00:00:00
abstract::The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386177a0
更新日期:1997-03-13 00:00:00
abstract::Visual transduction in vertebrate photoreceptors is thought to involve a diffusible internal transmitter which links photon absorption in disk membranes to the conductance decrease in the plasma membrane of the outer segment. The desensitisation of the photoresponse which occurs during and after illumination may also ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283085a0
更新日期:1980-01-03 00:00:00
abstract::Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382829a0
更新日期:1996-08-29 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13557
更新日期:2014-09-11 00:00:00
abstract::Although cell adhesion to substrate must ultimately depend on 'sticking' by physical forces at the outer surface, we suggest that control is exercised through the 'grip' of the cytoskeleton. Our experiments indicate that grip can be relaxed by agents which release surface glycoproteins from some form of side-to-side o...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/267124a0
更新日期:1977-05-12 00:00:00
abstract::The midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous opioids and is a major target of analgesic action in the central nervous system. It has been proposed that the analgesic effect of opioids on the PAG works by suppressing the inhibitory influence of the neurotransmitter GABA (gamm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/37610
更新日期:1997-12-11 00:00:00
abstract::The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321785a0
更新日期:1986-06-19 00:00:00
abstract::Plate tectonics successfully describes the surface of Earth as a mosaic of moving lithospheric plates. But it is not clear what happens at the base of the plates, the lithosphere-asthenosphere boundary (LAB). The LAB has been well imaged with converted teleseismic waves, whose 10-40-kilometre wavelength controls the s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14146
更新日期:2015-02-05 00:00:00
abstract::Complex topological configurations are fertile ground for exploring emergent phenomena and exotic phases in condensed-matter physics. For example, the recent discovery of polarization vortices and their associated complex-phase coexistence and response under applied electric fields in superlattices of (PbTiO3)n/(SrTiO...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1092-8
更新日期:2019-04-01 00:00:00
abstract::Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/417087a
更新日期:2002-05-02 00:00:00
abstract::The extinction rate of populations is predicted to rise under increasing rates of environmental change. If a population experiencing increasingly stressful conditions lacks appropriate phenotypic plasticity or access to more suitable habitats, then genetic change may be the only way to avoid extinction. Evolutionary r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11879
更新日期:2013-02-28 00:00:00
abstract::Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation1,2. How cells ensure that recombination occurs in the PAR is unknown. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2327-4
更新日期:2020-06-01 00:00:00
abstract::Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04793
更新日期:2006-05-18 00:00:00
abstract::Fixed nitrogen (N) often limits the growth of organisms in terrestrial and aquatic biomes, and N availability has been important in controlling the CO2 balance of modern and ancient oceans. The fixation of atmospheric dinitrogen gas (N2) to ammonia is catalysed by nitrogenase and provides a fixed N for N-limited envir...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35088063
更新日期:2001-08-09 00:00:00
abstract::The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/432969a
更新日期:2004-12-23 00:00:00
abstract::In nature, organisms are exposed to chronic low-dose ultraviolet light (CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA repair by the nucleotide excision repair pathway and for checkpoin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07580
更新日期:2009-01-29 00:00:00
abstract::Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05840
更新日期:2007-05-24 00:00:00
abstract::Because monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease. Attachment of metal ions to antibodies by means of bifunctional chelating a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316265a0
更新日期:1985-07-18 00:00:00
abstract::Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature05660
更新日期:2007-02-22 00:00:00
abstract::Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359653a0
更新日期:1992-10-15 00:00:00
abstract::Understanding the relative timings of climate events in the Northern and Southern hemispheres is a prerequisite for determining the causes of abrupt climate changes. But climate records from the Patagonian Andes and New Zealand for the period of transition from glacial to interglacial conditions--about 14.6-10 kyr bef...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35057252
更新日期:2001-02-15 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07372-3
更新日期:2018-12-01 00:00:00
abstract::We have shown previously that chromosome VI of Saccharomyces cerevisiae contains nine origins of DNA replication that differ in initiation frequency and replicate sequentially during the S phase of the cell cycle. Here we show that there are links between activation of these multiple origins and regulation of S-phase ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/27007
更新日期:1998-10-08 00:00:00
abstract::Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03894
更新日期:2005-08-18 00:00:00
abstract::The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298389a0
更新日期:1982-07-22 00:00:00
abstract::The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NA...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314592a0
更新日期:1985-04-18 00:00:00
abstract::Recently, several groups have initiated studies on cytosolic proteins that bind to isolated secretory vesicle membranes in the presence of Ca2+ in order to identify proteins that may regulate exocytosis. Two major chromaffin granule binding proteins, of molecular weights 32,000 (32K) and 34,000 (34K), were reported to...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308208a0
更新日期:1984-03-08 00:00:00
abstract::The presence of noise in a signal transduction system usually interferes with its ability to transfer information reliably. But many nonlinear systems can use noise to enhance performance, and this phenomenon, called stochastic resonance, may underlie the extraordinary ability of some biological systems to detect and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378362a0
更新日期:1995-11-23 00:00:00
abstract::Atlantic tropical cyclone activity, as measured by annual storm counts, reached anomalous levels over the past decade. The short nature of the historical record and potential issues with its reliability in earlier decades, however, has prompted an ongoing debate regarding the reality and significance of the recent ris...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08219
更新日期:2009-08-13 00:00:00