Observation of room-temperature polar skyrmions.

abstract：:Predation can be intense, creating strong direct and indirect effects throughout food webs. In addition, ecologists increasingly recognize that fluxes of organisms across ecosystem boundaries can have major consequences for community dynamics. Species with complex life histories often shift habitats during their life ...

journal_title：Nature

authors： Knight TM,McCoy MW,Chase JM,McCoy KA,Holt RD

更新日期：2005-10-06 00:00:00

abstract：:The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...

journal_title：Nature

authors： Rossier J,Audigier Y,Ling N,Cros J,Udenfriend S

更新日期：1980-11-06 00:00:00

abstract：:The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue remodelling, eliminates supernumerary cell populations and provides structural elements such as hair and skin. In the nervous system, selec...

journal_title：Nature

authors： Smeyne RJ,Vendrell M,Hayward M,Baker SJ,Miao GG,Schilling K,Robertson LM,Curran T,Morgan JI

更新日期：1993-05-13 00:00:00

abstract：:The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be used to augment immune-mediated elimination of tumours and have resulted in durable responses in patients with...

journal_title：Nature

authors： Alspach E,Lussier DM,Miceli AP,Kizhvatov I,DuPage M,Luoma AM,Meng W,Lichti CF,Esaulova E,Vomund AN,Runci D,Ward JP,Gubin MM,Medrano RFV,Arthur CD,White JM,Sheehan KCF,Chen A,Wucherpfennig KW,Jacks T,Unanue ER,Ar

更新日期：2019-10-01 00:00:00

abstract：:Olefin chemistry, through pericyclic reactions, polymerizations, oxidations, or reductions, has an essential role in the manipulation of organic matter. Despite its importance, olefin synthesis still relies largely on chemistry introduced more than three decades ago, with metathesis being the most recent addition. Her...

journal_title：Nature

authors： Edwards JT,Merchant RR,McClymont KS,Knouse KW,Qin T,Malins LR,Vokits B,Shaw SA,Bao DH,Wei FL,Zhou T,Eastgate MD,Baran PS

更新日期：2017-05-11 00:00:00

abstract：:Ligand-gated ion channels are multi-subunit complexes where each subunit-type is encoded by several related genes. Heterologous expression of any one of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits, either alone or with any beta-type subunit, typically yields functional nAChR channels. A ...

journal_title：Nature

authors： Ramirez-Latorre J,Yu CR,Qu X,Perin F,Karlin A,Role L

更新日期：1996-03-28 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...

journal_title：Nature

authors： Fischer KD,Zmuldzinas A,Gardner S,Barbacid M,Bernstein A,Guidos C

更新日期：1995-03-30 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA-protein complex called the spliceosome. But whether splicing is catalysed by small nuclear RNAs in the spliceosome is unresolved. As the spliceosome is a metalloenzyme, it is importan...

journal_title：Nature

authors： Yean SL,Wuenschell G,Termini J,Lin RJ

更新日期：2000-12-14 00:00:00

abstract：:Exchange dynamics between molecules free in solution and bound to the surface of a large supramolecular structure, a polymer, a membrane or solid support are important in many phenomena in biology and materials science. Here we present a novel and generally applicable solution NMR technique, known as dark-state exchan...

journal_title：Nature

authors： Fawzi NL,Ying J,Ghirlando R,Torchia DA,Clore GM

更新日期：2011-10-30 00:00:00

abstract：:Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per a...

journal_title：Nature

authors： Marouli E,Graff M,Medina-Gomez C,Lo KS,Wood AR,Kjaer TR,Fine RS,Lu Y,Schurmann C,Highland HM,Rüeger S,Thorleifsson G,Justice AE,Lamparter D,Stirrups KE,Turcot V,Young KL,Winkler TW,Esko T,Karaderi T,Locke AE,Mas

更新日期：2017-02-09 00:00:00

abstract：:Arachidonic acid is released by phospholipase A2 when activation of N-methyl-D-aspartate (NMDA) receptors by neurotransmitter glutamate raises the calcium concentration in neurons, for example during the initiation of long-term potentiation and during brain anoxia. Here we investigate the effect of arachidonic acid on...

journal_title：Nature

authors： Miller B,Sarantis M,Traynelis SF,Attwell D

更新日期：1992-02-20 00:00:00

abstract：:p60src, the transforming protein of Rous sarcoma virus (RSV), is a protein kinase that has a strict specificity for tyrosine. The phosphorylation of cellular proteins by p60src (ref. 4) results in transformation. Recently, Barker and Dayhoff discovered that residues 259-485 of p60src have 22% sequence identity with re...

journal_title：Nature

authors： Kamps MP,Taylor SS,Sefton BM

更新日期：1984-08-16 00:00:00

abstract：:Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancem...

journal_title：Nature

authors： Raiteri CM,Villata M,Acosta-Pulido JA,Agudo I,Arkharov AA,Bachev R,Baida GV,Benítez E,Borman GA,Boschin W,Bozhilov V,Butuzova MS,Calcidese P,Carnerero MI,Carosati D,Casadio C,Castro-Segura N,Chen WP,Damljanovic G,D'

更新日期：2017-12-21 00:00:00

abstract：:Traditionally, entanglement was considered to be a quirk of microscopic objects that defied a common-sense explanation. Now, however, entanglement is recognized to be ubiquitous and robust. With the realization that entanglement can occur in macroscopic systems - and with the development of experiments aimed at exploi...

journal_title：Nature

authors： Vedral V

更新日期：2008-06-19 00:00:00

abstract：:The Gakkel ridge, which extends under the Arctic ice cap for approximately 1,800 km, is the slowest spreading ocean ridge on Earth. Its spreading created the Eurasian basin, which is isolated from the rest of the oceanic mantle by North America, Eurasia and the Lomonosov ridge. The Gakkel ridge thus provides unique op...

journal_title：Nature

authors： Goldstein SL,Soffer G,Langmuir CH,Lehnert KA,Graham DW,Michael PJ

更新日期：2008-05-01 00:00:00

abstract：:Collections in early Middle Miocene deposits at Pasalar in Turkey have yielded a very rich fauna. Included in this are two hominoid species referred here to Sivapithecus darwini (Abel) 1902 and Ramapithecus wickeri (Leakey) 1962. These are both more primitive morphologically and earlier in time than other species of t...

journal_title：Nature

authors： Andrews P,Tobien H

更新日期：1977-08-25 00:00:00

abstract：:Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels disp...

journal_title：Nature

authors： Berridge MJ

更新日期：1993-01-28 00:00:00

abstract：:The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The...

journal_title：Nature

authors： Margulies M,Egholm M,Altman WE,Attiya S,Bader JS,Bemben LA,Berka J,Braverman MS,Chen YJ,Chen Z,Dewell SB,Du L,Fierro JM,Gomes XV,Godwin BC,He W,Helgesen S,Ho CH,Irzyk GP,Jando SC,Alenquer ML,Jarvie TP,Jirage K

更新日期：2005-09-15 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or HHV 8) is a virus that is consistently present in Kaposi's sarcoma and in primary-effusion (body-cavity-based) lymphomas, malignancies that occur frequently, but not exclusively, in AIDS patients. KSHV is a gamma herpesvirus with homo...

journal_title：Nature

authors： Arvanitakis L,Geras-Raaka E,Varma A,Gershengorn MC,Cesarman E

更新日期：1997-01-23 00:00:00

abstract：:The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...

journal_title：Nature

authors： Richardson JD,Kasper JC,Wang C,Belcher JW,Lazarus AJ

更新日期：2008-07-03 00:00:00

abstract：:Understanding exotic forms of magnetism in quantum mechanical systems is a central goal of modern condensed matter physics, with implications for systems ranging from high-temperature superconductors to spintronic devices. Simulating magnetic materials in the vicinity of a quantum phase transition is computationally i...

journal_title：Nature

authors： Simon J,Bakr WS,Ma R,Tai ME,Preiss PM,Greiner M

更新日期：2011-04-21 00:00:00

abstract：:Human epithelia are permanently challenged by bacteria and fungi, including commensal and pathogenic microbiota. In the gut, the fraction of strict anaerobes increases from proximal to distal, reaching 99% of bacterial species in the colon. At colonic mucosa, oxygen partial pressure is below 25% of airborne oxygen con...

journal_title：Nature

authors： Schroeder BO,Wu Z,Nuding S,Groscurth S,Marcinowski M,Beisner J,Buchner J,Schaller M,Stange EF,Wehkamp J

更新日期：2011-01-20 00:00:00

abstract：:The central nervous system (CNS) requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for neural function. This environment is maintained by the 'blood-brain barrier' (BBB), which is composed of blood vessels whose endothelial cells display specialized tight...

journal_title：Nature

authors： Ben-Zvi A,Lacoste B,Kur E,Andreone BJ,Mayshar Y,Yan H,Gu C

更新日期：2014-05-22 00:00:00

abstract：:The extent to which an organism is selected to invest in defences against pathogens and parasites depends on the advantages that ensue should infection occur, but also on the costs of maintaining defences in the absence of infection. The presence of heritable variation in resistance suggests that costs exist, but we k...

journal_title：Nature

authors： Kraaijeveld AR,Godfray HC

更新日期：1997-09-18 00:00:00

abstract：:The antigen CD10 (common acute lymphoblastic leukaemia antigen), which is the zinc metalloprotease, neutral endopeptidase 24.11 (also known as NEP or 'enkephalinase'), is expressed by acute lymphoblastic leukaemias, normal lymphoid progenitors, mature polymorphonuclear leukocytes and certain nonhaematopoietic cells. C...

journal_title：Nature

authors： Shipp MA,Stefano GB,D'Adamio L,Switzer SN,Howard FD,Sinisterra J,Scharrer B,Reinherz EL

更新日期：1990-09-27 00:00:00

abstract：:A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...

journal_title：Nature

authors： Wagner CE,Harmon LJ,Seehausen O

更新日期：2012-07-19 00:00:00

abstract：:The direct involvement of the pituitary-adrenal axis in birth has been well established, at least in sheep, and its removal prolongs pregnancy. As part of the process the fetal sheep adrenal grows rapidly during the 10-15 d prepartum and is associated with a large rise in the plasma corticosteroid concentration. This ...

journal_title：Nature

authors： Roebuck MM,Jones CT,Holland D,Silman R

更新日期：1980-04-17 00:00:00

abstract：:We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the surface of cultured human haematopoietic cell lines by means of a monoclonal antibody. Although it is expressed on all cultured human haematopoietic cell lines te...

journal_title：Nature

authors： Omary MB,Trowbridge IS,Minowada J

更新日期：1980-08-28 00:00:00