Abstract：
:We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the surface of cultured human haematopoietic cell lines by means of a monoclonal antibody. Although it is expressed on all cultured human haematopoietic cell lines tested, including the inducible promyelocytic tumour cell line HL-60 (ref. 1), it is not present in readily detectable amounts on most normal or leukaemic human haematopoietic cells. HL-60 cells, on exposure in vitro to appropriate chemical inducers, undergo morphological and functional differentiation along the granulocytic pathway or into macrophage-like cells. One consequence of in vitro induction in the specific loss of the glycoprotein from the surface of HL-60 cells. The molecule does not, however, seem to be a highly tissue-specific differentiation antigen because it is also found on human tumour cell lines derived from non-haematopoietic tissues. Rather, its expression seems to be related to cell proliferation. Preliminary chemical characterization suggests that the glycoprotein maybe identical to the abnormal glycoprotein previously reported by Bramwell and Harris to be associated with malignancy.
journal_name
Naturejournal_title
Natureauthors
Omary MB,Trowbridge IS,Minowada Jdoi
10.1038/286888a0subject
Has Abstractpub_date
1980-08-28 00:00:00pages
888-91issue
5776eissn
0028-0836issn
1476-4687journal_volume
286pub_type
杂志文章相关文献
NATURE文献大全abstract：:Mutation of the XRCC4 gene in mammalian cells prevents the formation of the signal and coding joints in the V(D)J recombination reaction, which is necessary for production of a functional immunoglobulin gene, and renders the cells highly sensitive to ionizing radiation. However, XRCC4 shares no sequence homology with ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/41358
更新日期：1997-07-31 00:00:00
abstract：:Features that were once considered exclusive to modern birds, such as feathers and a furcula, are now known to have first appeared in non-avian dinosaurs. However, relatively little is known of the early evolutionary history of the hyperinflated brain that distinguishes birds from other living reptiles and provides th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12424
更新日期：2013-09-05 00:00:00
abstract：:Down's syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation. Development of the DS brain is associated with decreased neuronal number and abnormal neuronal differentiation, and adults with DS develop Alzheimer's disease. The cause of the neurodegenerative process in DS is unknown. Here we...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/378776a0
更新日期：1995-12-21 00:00:00
abstract：:Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/46045
更新日期：1999-11-11 00:00:00
abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/256556a0
更新日期：1975-08-14 00:00:00
abstract：:To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415156a
更新日期：2002-01-10 00:00:00
abstract：:Remodelling its shape, or morphogenesis, is a fundamental property of living tissue. It underlies much of embryonic development and numerous pathologies. Convergent extension (CE) of the axial mesoderm of vertebrates is an intensively studied model for morphogenetic processes that rely on cell rearrangement. It involv...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02620
更新日期：2004-07-15 00:00:00
abstract：:Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. At...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12663
更新日期：2013-10-17 00:00:00
abstract：:Jawless vertebrates use variable lymphocyte receptors (VLR) comprised of leucine-rich-repeat (LRR) segments as counterparts of the immunoglobulin-based receptors that jawed vertebrates use for antigen recognition. Highly diverse VLR genes are somatically assembled by the insertion of variable LRR sequences into incomp...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08068
更新日期：2009-06-11 00:00:00
abstract：:The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35014569
更新日期：2000-06-01 00:00:00
abstract：:Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic dri...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2164-5
更新日期：2020-04-01 00:00:00
abstract：:The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders1-4. Here we show that the assembly of the viral community in neonates takes place in distinct steps. Fluorescent staining of virus-like particles purified from...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2192-1
更新日期：2020-05-01 00:00:00
abstract：:Published data from X-ray telescopes are not adequate to reveal the fluctuations in the surface brightness of the background radiation caused by clustering or superclustering of the sources giving rise to the background. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/238020a0
更新日期：1972-07-07 00:00:00
abstract：:Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11465
更新日期：2012-11-08 00:00:00
abstract：:Resolving current concerns about the role of biodiversity on ecosystems calls for understanding the separate roles of changes in species numbers and of composition. Recent work shows that primary productivity often, but not always, saturates with species richness within single trophic levels. However, any interpretati...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/416837a
更新日期：2002-04-25 00:00:00
abstract：:During an immune response, hypermutation of immunoglobulin genes in B cells proliferating within germinal centres (GCs) generates variant antibodies that react with higher affinity against either foreign or self antigens. Several experiments suggest that self-reactive B cells may be censored at this stage of the immun...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/375334a0
更新日期：1995-05-25 00:00:00
abstract：:B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Dev...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/354308a0
更新日期：1991-11-28 00:00:00
abstract：:Immune-challenged vertebrate females transfer specific antibodies to their offspring, but this gratuitous immunity cannot operate in invertebrates. Here we show that constitutive immune defence is enhanced in sexual offspring of the bumble-bee Bombus terrestris L. when the parental colony is immune-challenged. Our fin...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35107138
更新日期：2001-11-29 00:00:00
abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08151
更新日期：2009-07-09 00:00:00
abstract：:Although phytoalexins have long been inferred to be important in the defence of plants against fungal infection, there are few reports showing that they provide resistance to infection. Several plants, including grapevine, synthesize the stilbene-type phytoalexin resveratrol when attacked by pathogens. Stilbenes with ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/361153a0
更新日期：1993-01-14 00:00:00
abstract：:Water masers are found in dense molecular clouds closely associated with supermassive black holes at the centres of active galaxies. On the basis of the understanding of the local water-maser luminosity function, it was expected that masers at intermediate and high redshifts would be extremely rare. However, galaxies ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07544
更新日期：2008-12-18 00:00:00
abstract：:Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/376788a0
更新日期：1995-08-31 00:00:00
abstract：:The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/300771a0
更新日期：1982-12-23 00:00:00
abstract：:The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...
journal_title：Nature
pub_type： 社论
doi：10.1038/356365a0
更新日期：1992-04-02 00:00:00
abstract：:The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/416763a
更新日期：2002-04-18 00:00:00
abstract：:Spontaneous symmetry breaking plays a key role in our understanding of nature. In relativistic quantum field theory, a broken continuous symmetry leads to the emergence of two types of fundamental excitation: massless Nambu-Goldstone modes and a massive 'Higgs' amplitude mode. An excitation of Higgs type is of crucial...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11255
更新日期：2012-07-25 00:00:00
abstract：:The European Commission has made good progress in gathering support for its new programme of basic and applied research. Now Europe's industries and heads of state need to fulfill promises made two years ago. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415457a
更新日期：2002-01-31 00:00:00
abstract：:Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04245
更新日期：2006-01-19 00:00:00
abstract：:In the ocean, the chemical forms of nitrogen that are readily available for biological use (known collectively as 'fixed' nitrogen) fuel the global phytoplankton productivity that exports carbon to the deep ocean. Accordingly, variation in the oceanic fixed nitrogen reservoir has been proposed as a cause of glacial-in...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature12397
更新日期：2013-09-12 00:00:00
abstract：:Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has bee...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09627
更新日期：2010-12-16 00:00:00
