Abstract:
:The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report that the retinoblastoma tumour-suppressor protein (Rb), a regulator of G1 exit, functionally links Ras to passage through the G1 phase. Inactivation of Ras in cycling cells caused a decline in cyclin D1 protein levels, accumulation of the hypophosphorylated, growth-suppressive form of Rb, and G1 arrest. When Rb was disrupted either genetically or biochemically, cells failed to arrest in G1 following Ras inactivation. In contrast, inactivation of Ras in quiescent cells prevented growth-factor induction of both immediate-early gene transcription and exit from G0 in an Rb-independent manner. These data suggest that Rb is an essential G1-specific mediator that links Ras-dependent mitogenic signalling to cell-cycle regulation.
journal_name
Naturejournal_title
Natureauthors
Peeper DS,Upton TM,Ladha MH,Neuman E,Zalvide J,Bernards R,DeCaprio JA,Ewen MEdoi
10.1038/386177a0subject
Has Abstractpub_date
1997-03-13 00:00:00pages
177-81issue
6621eissn
0028-0836issn
1476-4687journal_volume
386pub_type
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