Obesity as a medical problem.

Abstract:

:Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. Obesity is defined by a body-mass index (weight divided by square of the height) of 30 kg m(-2) or greater, but this does not take into account the morbidity and mortality associated with more modest degrees of overweight, nor the detrimental effect of intra-abdominal fat. The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals, but an epidemic that threatens global well being.

journal_name

Nature

journal_title

Nature

authors

Kopelman PG

doi

10.1038/35007508

keywords:

subject

Has Abstract

pub_date

2000-04-06 00:00:00

pages

635-43

issue

6778

eissn

0028-0836

issn

1476-4687

journal_volume

404

pub_type

杂志文章,评审

相关文献

NATURE文献大全
  • Worries about infectious cancer.

    abstract::The recent discovery that the human T-cell lymphoma leukemia virus (HTLV) may be the agent of transmission of T-cell lymphoid malignancies raises ethical questions for blood transfusion services. The effort to avoid use of contaminated blood is dependent to a large extent on the willingness and ability of donors to g...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/302567a0

    authors:

    更新日期:1983-04-14 00:00:00

  • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

    abstract::Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies. Many MLL-fusion partners are members of the super elongation complex (SEC), a critical regulator of transcriptional elongation, suggesting ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10509

    authors: Dawson MA,Prinjha RK,Dittmann A,Giotopoulos G,Bantscheff M,Chan WI,Robson SC,Chung CW,Hopf C,Savitski MM,Huthmacher C,Gudgin E,Lugo D,Beinke S,Chapman TD,Roberts EJ,Soden PE,Auger KR,Mirguet O,Doehner K,Delwel R,

    更新日期:2011-10-02 00:00:00

  • High-frequency genomic rearrangements involving archaebacterial repeat sequence elements.

    abstract::Halobacterium halobium is an obligately halophilic archaebacterium of interest to molecular biologists for many reasons, one of which is the unexplained high frequency (10(-4)-10(-2) mutants per cell plated) at which it yields readily identifiable and unstable mutants. We showed previously that the genome of H. halobi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/299182a0

    authors: Sapienza C,Rose MR,Doolittle WF

    更新日期:1982-09-09 00:00:00

  • The effect of energy feedbacks on continental strength.

    abstract::The classical strength profile of continents is derived from a quasi-static view of their rheological response to stress--one that does not consider dynamic interactions between brittle and ductile layers. Such interactions result in complexities of failure in the brittle-ductile transition and the need to couple ener...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04868

    authors: Regenauer-Lieb K,Weinberg RF,Rosenbaum G

    更新日期:2006-07-06 00:00:00

  • Chinese effort to clone gene-edited monkeys kicks off.

    abstract:: ...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/d41586-019-00292-w

    authors: Cyranoski D

    更新日期:2019-02-01 00:00:00

  • Molecular structure of F-actin and location of surface binding sites.

    abstract::Comparisons of three-dimensional maps of vertebrate muscle thin filaments obtained by cryo-electron microscopy and image analysis, reveal the molecular structure of F-actin, the location of the C terminus of the monomer and the positions of the binding sites of tropomyosin, the myosin head and the N-terminal portion o...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/348217a0

    authors: Milligan RA,Whittaker M,Safer D

    更新日期:1990-11-15 00:00:00

  • Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation.

    abstract::Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. Most synapses that exhibit LTP use an excitatory amino-acid neurotransmitter that acts on two types of rec...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/338500a0

    authors: Davies SN,Lester RA,Reymann KG,Collingridge GL

    更新日期:1989-04-06 00:00:00

  • Accessory cell-dependent selection of specific T-cell functions.

    abstract::Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/304442a0

    authors: Ramila G,Erb P

    更新日期:1983-08-04 00:00:00

  • Chromosome-specific nonrandom sister chromatid segregation during stem-cell division.

    abstract::Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue. Sister chromatids may be distinguished and segregated nonrandomly in asymmetrically dividing stem cells, although the underlying mechanism and the purpose it may serve remain elusive. Here...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12106

    authors: Yadlapalli S,Yamashita YM

    更新日期:2013-06-13 00:00:00

  • An embryonic pattern of expression of a human fetal globin gene in transgenic mice.

    abstract::During the evolution of the beta-globin family gene in vertebrates, different globin genes acquired different developmental patterns of expression. In mammals, specific 'embryonic' beta-like globins are synthesized in the earliest erythroid cells, which differentiate in the yolk sac of the embryo. In most mammals the ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/319685a0

    authors: Chada K,Magram J,Costantini F

    更新日期:1986-02-20 00:00:00

  • Replication of Epstein-Barr virus in human epithelial cells infected in vitro.

    abstract::Epstein-Barr virus (EBV), a member of the herpes group of viruses and the aetiological agent of infectious mononucleosis, is usually thought of as a lymphotrophic virus with the ability to transform B lymphocytes. So the association of EBV with nasopharyngeal carcinoma is puzzling, especially given the lack of success...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/306480a0

    authors: Sixbey JW,Vesterinen EH,Nedrud JG,Raab-Traub N,Walton LA,Pagano JS

    更新日期:1983-12-01 00:00:00

  • A genetically augmented future.

    abstract:: ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/d41586-018-07642-0

    authors: Clayton EW

    更新日期:2018-12-01 00:00:00

  • Links between gut microbes and depression strengthened.

    abstract:: ...

    journal_title:Nature

    pub_type: 评论,社论

    doi:10.1038/d41586-019-00483-5

    authors:

    更新日期:2019-02-01 00:00:00

  • Dynamical age differences among coeval star clusters as revealed by blue stragglers.

    abstract::Globular star clusters that formed at the same cosmic time may have evolved rather differently from the dynamical point of view (because that evolution depends on the internal environment) through a variety of processes that tend progressively to segregate stars more massive than the average towards the cluster centre...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11686

    authors: Ferraro FR,Lanzoni B,Dalessandro E,Beccari G,Pasquato M,Miocchi P,Rood RT,Sigurdsson S,Sills A,Vesperini E,Mapelli M,Contreras R,Sanna N,Mucciarelli A

    更新日期:2012-12-20 00:00:00

  • Information causality as a physical principle.

    abstract::Quantum physics has remarkable distinguishing characteristics. For example, it gives only probabilistic predictions (non-determinism) and does not allow copying of unknown states (no-cloning). Quantum correlations may be stronger than any classical ones, but information cannot be transmitted faster than light (no-sign...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature08400

    authors: Pawłowski M,Paterek T,Kaszlikowski D,Scarani V,Winter A,Zukowski M

    更新日期:2009-10-22 00:00:00

  • Recent global-warming hiatus tied to equatorial Pacific surface cooling.

    abstract::Despite the continued increase in atmospheric greenhouse gas concentrations, the annual-mean global temperature has not risen in the twenty-first century, challenging the prevailing view that anthropogenic forcing causes climate warming. Various mechanisms have been proposed for this hiatus in global warming, but thei...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature12534

    authors: Kosaka Y,Xie SP

    更新日期:2013-09-19 00:00:00

  • Entanglement of two quantum memories via fibres over dozens of kilometres.

    abstract::A quantum internet that connects remote quantum processors1,2 should enable a number of revolutionary applications such as distributed quantum computing. Its realization will rely on entanglement of remote quantum memories over long distances. Despite enormous progress3-12, at present the maximal physical separation a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-1976-7

    authors: Yu Y,Ma F,Luo XY,Jing B,Sun PF,Fang RZ,Yang CW,Liu H,Zheng MY,Xie XP,Zhang WJ,You LX,Wang Z,Chen TY,Zhang Q,Bao XH,Pan JW

    更新日期:2020-02-01 00:00:00

  • Melanocyte biology and skin pigmentation.

    abstract::Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative ...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature05660

    authors: Lin JY,Fisher DE

    更新日期:2007-02-22 00:00:00

  • Faulting induced by precipitation of water at grain boundaries in hot subducting oceanic crust.

    abstract::Dehydration embrittlement has been proposed to explain both intermediate- and deep-focus earthquakes in subduction zones. Because such earthquakes primarily occur at shallow depths or within the core of the subducting plate, dehydration at relatively low temperatures has been emphasized. However, recent careful reloca...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02475

    authors: Zhang J,Green HW,Bozhilov K,Jin Z

    更新日期:2004-04-08 00:00:00

  • Quantum simulation of antiferromagnetic spin chains in an optical lattice.

    abstract::Understanding exotic forms of magnetism in quantum mechanical systems is a central goal of modern condensed matter physics, with implications for systems ranging from high-temperature superconductors to spintronic devices. Simulating magnetic materials in the vicinity of a quantum phase transition is computationally i...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09994

    authors: Simon J,Bakr WS,Ma R,Tai ME,Preiss PM,Greiner M

    更新日期:2011-04-21 00:00:00

  • Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria.

    abstract::The human gene for the hepatic enzyme phenylalanine hydroxylase has been cloned and used to analyse the phenylalanine hydroxylase locus in the human genome. The detection of polymorphisms in this locus by several restriction enzymes has allowed feasibility studies of prenatal diagnosis of classical phenylketonuria and...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/306151a0

    authors: Woo SL,Lidsky AS,Güttler F,Chandra T,Robson KJ

    更新日期:1983-11-10 00:00:00

  • Tumour exosome integrins determine organotropic metastasis.

    abstract::Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and ep...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature15756

    authors: Hoshino A,Costa-Silva B,Shen TL,Rodrigues G,Hashimoto A,Tesic Mark M,Molina H,Kohsaka S,Di Giannatale A,Ceder S,Singh S,Williams C,Soplop N,Uryu K,Pharmer L,King T,Bojmar L,Davies AE,Ararso Y,Zhang T,Zhang H,Her

    更新日期:2015-11-19 00:00:00

  • MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.

    abstract::Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14216

    authors: Boersma V,Moatti N,Segura-Bayona S,Peuscher MH,van der Torre J,Wevers BA,Orthwein A,Durocher D,Jacobs JJL

    更新日期:2015-05-28 00:00:00

  • Transposition of Tn554 does not generate a target duplication.

    abstract::Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/307292a0

    authors: Murphy E,Löfdahl S

    更新日期:1984-01-19 00:00:00

  • Increased forest ecosystem carbon and nitrogen storage from nitrogen rich bedrock.

    abstract::Nitrogen (N) limits the productivity of many ecosystems worldwide, thereby restricting the ability of terrestrial ecosystems to offset the effects of rising atmospheric CO(2) emissions naturally. Understanding input pathways of bioavailable N is therefore paramount for predicting carbon (C) storage on land, particular...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10415

    authors: Morford SL,Houlton BZ,Dahlgren RA

    更新日期:2011-08-31 00:00:00

  • Bending-related faulting and mantle serpentinization at the Middle America trench.

    abstract::The dehydration of subducting oceanic crust and upper mantle has been inferred both to promote the partial melting leading to arc magmatism and to induce intraslab intermediate-depth earthquakes, at depths of 50-300 km. Yet there is still no consensus about how slab hydration occurs or where and how much chemically bo...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01961

    authors: Ranero CR,Morgan JP,McIntosh K,Reichert C

    更新日期:2003-09-25 00:00:00

  • Coupling of surface temperatures and atmospheric CO2 concentrations during the Palaeozoic era.

    abstract::Atmospheric carbon dioxide concentrations seem to have been several times modern levels during much of the Palaeozoic era (543-248 million years ago), but decreased during the Carboniferous period to concentrations similar to that of today. Given that carbon dioxide is a greenhouse gas, it has been proposed that surfa...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature06085

    authors: Came RE,Eiler JM,Veizer J,Azmy K,Brand U,Weidman CR

    更新日期:2007-09-13 00:00:00

  • Nickel and copper accumplation as essential elements in 10-A manganite of deep-sea manganese nodules.

    abstract::MANY ferromanganese minerals have been found in marine manganese deposits. There have been terminological and intrinsic problems in accurately defining the constituents of manganese nodules(1), but 10-A manganite and delta-MnO(2) which are often compared with todorokite and birnessite seem to be the only major constit...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/279411a0

    authors: Usui A

    更新日期:1979-05-31 00:00:00

  • Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster.

    abstract::The extent to which an organism is selected to invest in defences against pathogens and parasites depends on the advantages that ensue should infection occur, but also on the costs of maintaining defences in the absence of infection. The presence of heritable variation in resistance suggests that costs exist, but we k...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/38483

    authors: Kraaijeveld AR,Godfray HC

    更新日期:1997-09-18 00:00:00

  • Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.

    abstract::The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature22313

    authors: Yan KS,Janda CY,Chang J,Zheng GXY,Larkin KA,Luca VC,Chia LA,Mah AT,Han A,Terry JM,Ootani A,Roelf K,Lee M,Yuan J,Li X,Bolen CR,Wilhelmy J,Davies PS,Ueno H,von Furstenberg RJ,Belgrader P,Ziraldo SB,Ordonez H,H

    更新日期:2017-05-11 00:00:00