The 'far east' of biological ethics.

abstract：:Methane is a powerful greenhouse gas and is targeted for emissions mitigation by the US state of California and other jurisdictions worldwide1,2. Unique opportunities for mitigation are presented by point-source emitters-surface features or infrastructure components that are typically less than 10 metres in diameter a...

journal_title：Nature

authors： Duren RM,Thorpe AK,Foster KT,Rafiq T,Hopkins FM,Yadav V,Bue BD,Thompson DR,Conley S,Colombi NK,Frankenberg C,McCubbin IB,Eastwood ML,Falk M,Herner JD,Croes BE,Green RO,Miller CE

更新日期：2019-11-01 00:00:00

abstract：:Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established during vasculogenesis is unknown. Here we show, by lineage tracking in zebrafish embryos, that angioblast precursors for the trunk artery and vein are spatially mixed in the lateral posterior me...

journal_title：Nature

authors： Zhong TP,Childs S,Leu JP,Fishman MC

更新日期：2001-11-08 00:00:00

abstract：:S-100 protein, one of the unique proteins found in the nervous system, has recently been discovered unexpectedly in the rat anterior pituitary. Immunocytochemistry reveals that stellate, follicular and folliculostellate cells, and marginal cells of the rat anterior pituitary contain this protein; however, as far as we...

journal_title：Nature

authors： Ishikawa H,Nogami H,Shirasawa N

更新日期：1983-06-23 00:00:00

abstract：:A statute banning nuclear weapons research in Cambridge, Massachusetts, is scheduled for a referendum vote in November 1983. If passed, the act would require the city to fine or imprison violators after the ban takes effect in October 1985, and could have an impact on work done at Harvard University and the Massachus...

journal_title：Nature

authors： David P

更新日期：1983-09-15 00:00:00

abstract：:Nitrogen enrichment is widely thought to be responsible for the loss of plant species from temperate terrestrial ecosystems. This view is based on field surveys and controlled experiments showing that species richness correlates negatively with high productivity and nitrogen enrichment. However, as the type of nutrien...

journal_title：Nature

authors： Wassen MJ,Venterink HO,Lapshina ED,Tanneberger F

更新日期：2005-09-22 00:00:00

abstract：:Imperfect knowledge of the times at which 'snapshots' of a system are recorded degrades our ability to recover dynamical information, and can scramble the sequence of events. In X-ray free-electron lasers, for example, the uncertainty--the so-called timing jitter--between the arrival of an optical trigger ('pump') pul...

journal_title：Nature

authors： Fung R,Hanna AM,Vendrell O,Ramakrishna S,Seideman T,Santra R,Ourmazd A,Ourmazd A

更新日期：2016-04-28 00:00:00

abstract：:Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible reactions in the target sequence, such as photocrosslinking or cleavag...

journal_title：Nature

authors： Perrouault L,Asseline U,Rivalle C,Thuong NT,Bisagni E,Giovannangeli C,Le Doan T,Hélène C

更新日期：1990-03-22 00:00:00

abstract：:Nonrandom chromosome rearrangements, observed in a variety of human and animal tumours, are associated in some cases with enhanced expression or deregulation of cellular oncogenes. Recently, it was shown that normal, diploid rodent cells are neoplastically transformed following transfection with two cooperating oncoge...

journal_title：Nature

authors： Oshimura M,Gilmer TM,Barrett JC

更新日期：1985-08-15 00:00:00

abstract：:Arising from C. J. Phiel, C. A. Wilson, V. M.-Y. Lee & P. S. Klein 423, 435-439 (2003)A major unresolved issue in Alzheimer's disease is identifying the mechanisms that regulate proteolytic processing of amyloid precursor protein (APP)-glycogen synthase kinase-3 (GSK-3) isozymes are thought to be important in this re...

journal_title：Nature

authors： Jaworski T,Dewachter I,Lechat B,Gees M,Kremer A,Demedts D,Borghgraef P,Devijver H,Kügler S,Patel S,Woodgett JR,Van Leuven F

更新日期：2011-12-07 00:00:00

abstract：:Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing. Focal adhesions are multifunctional organelles that mediate cell-ECM adhesion, force transmission, cytoskeletal regulation and signalling. Focal adhesions consist of a complex network of trans-plasma-membrane ...

journal_title：Nature

authors： Kanchanawong P,Shtengel G,Pasapera AM,Ramko EB,Davidson MW,Hess HF,Waterman CM

更新日期：2010-11-25 00:00:00

abstract：:Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...

journal_title：Nature

authors： King IF,Yandava CN,Mabb AM,Hsiao JS,Huang HS,Pearson BL,Calabrese JM,Starmer J,Parker JS,Magnuson T,Chamberlain SJ,Philpot BD,Zylka MJ

更新日期：2013-09-05 00:00:00

abstract：:The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). NLRP3 is recruited to the dispersed TGN (dTGN) through ionic bondin...

journal_title：Nature

authors： Chen J,Chen ZJ

更新日期：2018-12-01 00:00:00

abstract：:Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...

journal_title：Nature

authors： Kretz M,Siprashvili Z,Chu C,Webster DE,Zehnder A,Qu K,Lee CS,Flockhart RJ,Groff AF,Chow J,Johnston D,Kim GE,Spitale RC,Flynn RA,Zheng GX,Aiyer S,Raj A,Rinn JL,Chang HY,Khavari PA

更新日期：2013-01-10 00:00:00

abstract：:Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice have shown that this lipid chaperone has a significant role in several aspects of metabolic syndrome, including type 2 diabetes and atheroscle...

journal_title：Nature

authors： Furuhashi M,Tuncman G,Görgün CZ,Makowski L,Atsumi G,Vaillancourt E,Kono K,Babaev VR,Fazio S,Linton MF,Sulsky R,Robl JA,Parker RA,Hotamisligil GS

更新日期：2007-06-21 00:00:00

abstract：:Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...

journal_title：Nature

authors： Holder AA,Lockyer MJ,Odink KG,Sandhu JS,Riveros-Moreno V,Nicholls SC,Hillman Y,Davey LS,Tizard ML,Schwarz RT

更新日期：1985-09-19 00:00:00

abstract：:Granular superconductivity occurs when microscopic superconducting grains are separated by non-superconducting regions; Josephson tunnelling between the grains establishes the macroscopic superconducting state. Although crystals of the copper oxide high-transition-temperature (high-Tc) superconductors are not granular...

journal_title：Nature

authors： Lang KM,Madhavan V,Hoffman JE,Hudson EW,Eisaki H,Uchida S,Davis JC

更新日期：2002-01-24 00:00:00

abstract：:Since the discovery of graphene, the family of two-dimensional materials has grown, displaying a broad range of electronic properties. Recent additions include semiconductors with spin-valley coupling, Ising superconductors that can be tuned into a quantum metal, possible Mott insulators with tunable charge-density wa...

journal_title：Nature

authors： Huang B,Clark G,Navarro-Moratalla E,Klein DR,Cheng R,Seyler KL,Zhong D,Schmidgall E,McGuire MA,Cobden DH,Yao W,Xiao D,Jarillo-Herrero P,Xu X

更新日期：2017-06-07 00:00:00

abstract：:Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...

journal_title：Nature

authors： Reed DA,Keitz BK,Oktawiec J,Mason JA,Runčevski T,Xiao DJ,Darago LE,Crocellà V,Bordiga S,Long JR

更新日期：2017-10-05 00:00:00

abstract：:Photosynthetic dinoflagellates are important aquatic primary producers and notorious causes of toxic 'red tides'. Typical dinoflagellate chloroplasts differ from all other plastids in having a combination of three envelope membranes and peridinin-chlorophyll a/c light-harvesting pigments. Despite evidence of a dinofla...

journal_title：Nature

authors： Zhang Z,Green BR,Cavalier-Smith T

更新日期：1999-07-08 00:00:00

abstract：:Chondrules and Ca-Al-rich inclusions (CAIs) are high-temperature components of meteorites that formed during transient heating events in the early Solar System. A major unresolved issue is the relative timing of CAI and chondrule formation. From the presence of chondrule fragments in an igneous CAI, it was concluded t...

journal_title：Nature

authors： Krot AN,Yurimoto H,Hutcheon ID,MacPherson GJ

更新日期：2005-04-21 00:00:00

abstract：:Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...

journal_title：Nature

authors： Grivennikov SI,Wang K,Mucida D,Stewart CA,Schnabl B,Jauch D,Taniguchi K,Yu GY,Osterreicher CH,Hung KE,Datz C,Feng Y,Fearon ER,Oukka M,Tessarollo L,Coppola V,Yarovinsky F,Cheroutre H,Eckmann L,Trinchieri G,Karin M

更新日期：2012-11-08 00:00:00

abstract：:The c-myc gene product is a nuclear protein expressed in a wide variety of cell types. It has been implicated in the control of normal cell growth as well as transformation, but its exact function is unknown. When the human promyelocytic leukaemia cell line HL60 is treated with retinoic acid, the cells differentiate i...

journal_title：Nature

authors： Bentley DL,Groudine M

更新日期：1986-06-12 00:00:00

abstract：:Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

journal_title：Nature

authors： Ramila G,Erb P

更新日期：1983-08-04 00:00:00

abstract：:Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to ...

journal_title：Nature

authors： Bader E,Migliorini A,Gegg M,Moruzzi N,Gerdes J,Roscioni SS,Bakhti M,Brandl E,Irmler M,Beckers J,Aichler M,Feuchtinger A,Leitzinger C,Zischka H,Wang-Sattler R,Jastroch M,Tschöp M,Machicao F,Staiger H,Häring HU,Chme

更新日期：2016-07-21 00:00:00

abstract：:Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...

journal_title：Nature

authors： Ng SW,Mitchell A,Kennedy JA,Chen WC,McLeod J,Ibrahimova N,Arruda A,Popescu A,Gupta V,Schimmer AD,Schuh AC,Yee KW,Bullinger L,Herold T,Görlich D,Büchner T,Hiddemann W,Berdel WE,Wörmann B,Cheok M,Preudhomme C,Domb

更新日期：2016-12-15 00:00:00

abstract：:Group selection may be defined as selection caused by the differential extinction or proliferation of groups. The socially polymorphic spider Anelosimus studiosus exhibits a behavioural polymorphism in which females exhibit either a 'docile' or 'aggressive' behavioural phenotype. Natural colonies are composed of a mix...

journal_title：Nature

authors： Pruitt JN,Goodnight CJ

更新日期：2014-10-16 00:00:00

abstract：:Cocaine is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulati...

journal_title：Nature

authors： Carrera MR,Ashley JA,Parsons LH,Wirsching P,Koob GF,Janda KD

更新日期：1995-12-14 00:00:00

abstract：:Oxygen and silicon isotope compositions of cherts and studies of protein evolution have been interpreted to reflect ocean temperatures of 55-85 degrees C during the early Palaeoarchaean era ( approximately 3.5 billion years ago). A recent study combining oxygen and hydrogen isotope compositions of cherts, however, mak...

journal_title：Nature

authors： Blake RE,Chang SJ,Lepland A

更新日期：2010-04-15 00:00:00

abstract：:Regular mesoporous oxide materials have been widely studied and have a range of potential applications, such as catalysis, absorption and separation. They are not generally considered for their optical and electronic properties. Elemental semiconductors with nanopores running through them represent a different form of...

journal_title：Nature

authors： Armatas GS,Kanatzidis MG

更新日期：2006-06-29 00:00:00

abstract：:Flash spectra of the total solar eclipse throughout all its phases have been obtained in the extreme ultraviolet for the first time. ...

journal_title：Nature

authors： Speer RJ,Garton WR,Morgan JF,Nicholls RW,Goldberg L,Parkinson WH,Reeves EM,Jones TJ,Paxton HJ,Shenton DB,Wilson R

更新日期：1970-04-18 00:00:00