GSK-3α/β kinases and amyloid production in vivo.

Abstract:

:Arising from C. J. Phiel, C. A. Wilson, V. M.-Y. Lee & P. S. Klein 423, 435-439 (2003)A major unresolved issue in Alzheimer's disease is identifying the mechanisms that regulate proteolytic processing of amyloid precursor protein (APP)-glycogen synthase kinase-3 (GSK-3) isozymes are thought to be important in this regulation. Phiel et al. proposed that GSK-3α, but not GSK-3β, controls production of amyloid. We analysed the proteolytic processing of mouse and human APP in mouse brain in vivo in five different genetic and viral models. Our data do not yield evidence for either GSK-3α-mediated or GSK-3β-mediated control of APP processing in brain in vivo.

journal_name

Nature

journal_title

Nature

authors

Jaworski T,Dewachter I,Lechat B,Gees M,Kremer A,Demedts D,Borghgraef P,Devijver H,Kügler S,Patel S,Woodgett JR,Van Leuven F

doi

10.1038/nature10615

subject

Has Abstract

pub_date

2011-12-07 00:00:00

pages

E4-5; discussion E6

issue

7376

eissn

0028-0836

issn

1476-4687

pii

nature10615

journal_volume

480

pub_type

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