Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

abstract：:There is compelling evidence that sleep contributes to the long-term consolidation of new memories. This function of sleep has been linked to slow (<1 Hz) potential oscillations, which predominantly arise from the prefrontal neocortex and characterize slow wave sleep. However, oscillations in brain potentials are comm...

journal_title：Nature

authors： Marshall L,Helgadóttir H,Mölle M,Born J

更新日期：2006-11-30 00:00:00

abstract：:In Fig. 3d this Letter, the R2 value should have been '0.19' instead of '0.66'; this has been corrected online. ...

journal_title：Nature

authors： Hoyt JR,Langwig KE,White JP,Kaarakka HM,Redell JA,Kurta A,DePue JE,Scullon WH,Parise KL,Foster JT,Frick WF,Kilpatrick AM

更新日期：2019-02-01 00:00:00

abstract：:A plasmalemmal Na(+)-Ca2+ exchange mechanism is an important electrogenic determinant of contractility in cardiac cells. As in other cell types, calcium influx by Na(+)-Ca2+ exchange is secondarily activated by cytoplasmic calcium and probably ATP, but these modulatory mechanisms are either absent or altered in isolat...

journal_title：Nature

authors： Hilgemann DW

更新日期：1990-03-15 00:00:00

abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

journal_title：Nature

authors： Carter P,Wells JA

更新日期：1988-04-07 00:00:00

abstract：:Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...

journal_title：Nature

authors： Groux H,Huet S,Valentin H,Pham D,Bernard A

更新日期：1989-05-11 00:00:00

abstract：:The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exo...

journal_title：Nature

authors： Xiang S,Cooper-Morgan A,Jiao X,Kiledjian M,Manley JL,Tong L

更新日期：2009-04-09 00:00:00

abstract：:The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation ...

journal_title：Nature

authors： Marmottant P,Hilgenfeldt S

更新日期：2003-05-08 00:00:00

abstract：:Genomes from all of the crucial bacterial pathogens of humans, plants and animals have now been sequenced, as have genomes from many of the important commensal, symbiotic and environmental microorganisms. Analysis of these sequences has revealed the forces that shape pathogen evolution and has brought to light unexpec...

journal_title：Nature

authors： Pallen MJ,Wren BW

更新日期：2007-10-18 00:00:00

abstract：:Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggest...

journal_title：Nature

authors： Rozakis-Adcock M,Fernley R,Wade J,Pawson T,Bowtell D

更新日期：1993-05-06 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Interleukin-5 (IL-5) specifically induces the differentiation of eosinophils, which are important in host defence and the pathogenesis of allergies and asthma. Structurally, IL-5 is a unique member of the short-chain helical-bundle subfamily of cytokines whose canonical motif contains four helices (A-D) arranged in an...

journal_title：Nature

authors： Dickason RR,Huston DP

更新日期：1996-02-15 00:00:00

abstract：:First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

journal_title：Nature

authors： May RM

更新日期：1976-06-10 00:00:00

abstract：:Targeting of proteins to appropriate subcellular compartments is a crucial process in all living cells. Secretory and membrane proteins usually contain an amino-terminal signal peptide, which is recognized by the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome. The SRP-riboso...

journal_title：Nature

authors： Janda CY,Li J,Oubridge C,Hernández H,Robinson CV,Nagai K

更新日期：2010-05-27 00:00:00

abstract：:Neurotransmitter release is initiated by influx of Ca2+ through voltage-gated Ca2+ channels, within 200 microseconds of the action potential arriving at the synaptic terminal, as the Ca2+ concentration increases from 100 nM to > 200 microM. Exocytosis requires high Ca2+ concentration, with a threshold of 20-50 microM ...

journal_title：Nature

authors： Sheng ZH,Rettig J,Cook T,Catterall WA

更新日期：1996-02-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Roduner E

更新日期：2019-03-01 00:00:00

abstract：:Interactions between animal viruses and antiviral antisera may exceptionally result in an apparent increase in viral infectivity. Halstead and coworkers demonstrated enhanced replication of dengue virus (a Flavivirus, family Togaviridae) in human or simian peripheral blood leucocytes carrying Fc receptors at subneutra...

journal_title：Nature

authors： Peiris JS,Porterfield JS

更新日期：1979-11-29 00:00:00

abstract：:During cellular translation of messenger RNAs by ribosomes, the translation apparatus sometimes pauses or stalls at the elongation and termination steps. With the exception of programmed stalling, which is usually used by cells for regulatory purposes, ribosomes stalled on mRNAs need to be terminated and recycled to m...

journal_title：Nature

authors： Ma C,Kurita D,Li N,Chen Y,Himeno H,Gao N

更新日期：2017-01-26 00:00:00

abstract：:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...

journal_title：Nature

authors： Sawyers C

更新日期：2004-11-18 00:00:00

abstract：:The Borrmann effect-a dramatic increase in transparency to X-ray beams-is observed when X-rays satisfying Bragg's law diffract through a perfect crystal. The minimization of absorption seen in the Borrmann effect has been explained by noting that the electric field of the X-ray beam approaches zero amplitude at the cr...

journal_title：Nature

authors： Pettifer RF,Collins SP,Laundy D

更新日期：2008-07-10 00:00:00

abstract：:The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCF(TIR1) and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the functio...

journal_title：Nature

authors： Gray WM,Kepinski S,Rouse D,Leyser O,Estelle M

更新日期：2001-11-15 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature24295. ...

journal_title：Nature

authors： Waldron A,Miller DC,Redding D,Mooers A,Kuhn TS,Nibbelink N,Roberts JT,Tobias JA,Gittleman JL

更新日期：2018-01-25 00:00:00

abstract：:To artists, the face is a mirror of the soul. To biologists, the face reflects remarkable structural diversity--think of bulldogs and wolfhounds or galapagos finches. How do such variations in skeletal form arise? Do the same mechanisms control skeletogenesis elsewhere in the body? The answers lie in the molecular mac...

journal_title：Nature

authors： Helms JA,Schneider RA

更新日期：2003-05-15 00:00:00

abstract：:In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alternative, PI(3)K-AKT-mTOR, pathway (which is ERK independent) or on modul...

journal_title：Nature

authors： Boussemart L,Malka-Mahieu H,Girault I,Allard D,Hemmingsson O,Tomasic G,Thomas M,Basmadjian C,Ribeiro N,Thuaud F,Mateus C,Routier E,Kamsu-Kom N,Agoussi S,Eggermont AM,Désaubry L,Robert C,Vagner S

更新日期：2014-09-04 00:00:00

abstract：:The terminal differentiation of myogenic cells initiates in the proximal portion of the limb bud whereas the distal region remains undifferentiated and proliferative. The apical ectodermal ridge maintains the progress zone in an undifferentiated state and induces proliferation of limb mesenchymal cells. Hox-7.1, a hom...

journal_title：Nature

authors： Song K,Wang Y,Sassoon D

更新日期：1992-12-03 00:00:00

abstract：:The Duchenne muscular dystrophy (DMD) locus has been localized to the short arm of the human X chromosome (Xp21) by detection of structural abnormalities and by genetic linkage studies. A library highly enriched for human DNA from Xp21 was constructed using DNA isolated from a male patient who had a visible deletion a...

journal_title：Nature

authors： Monaco AP,Bertelson CJ,Middlesworth W,Colletti CA,Aldridge J,Fischbeck KH,Bartlett R,Pericak-Vance MA,Roses AD,Kunkel LM

更新日期：1985-08-29 00:00:00

abstract：:Overfishing of large-bodied benthic fishes and their subsequent population collapses on the Scotian Shelf of Canada's east coast and elsewhere resulted in restructuring of entire food webs now dominated by planktivorous, forage fish species and macroinvertebrates. Despite the imposition of strict management measures i...

journal_title：Nature

authors： Frank KT,Petrie B,Fisher JA,Leggett WC

更新日期：2011-07-27 00:00:00

abstract：:Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller th...

journal_title：Nature

authors： Barth RK,Kim BS,Lan NC,Hunkapiller T,Sobieck N,Winoto A,Gershenfeld H,Okada C,Hansburg D,Weissman IL

更新日期：1985-08-08 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a major pathogen in immunosuppressed individuals, including patients with acquired immune deficiency syndrome. The nucleoside analogue ganciclovir (9-(1,3-dihydroxy-2-propoxymethyl)-guanine) is one of the few drugs available to treat HCMV infections, but resistant virus is a growing pro...

journal_title：Nature

authors： Sullivan V,Talarico CL,Stanat SC,Davis M,Coen DM,Biron KK

更新日期：1992-07-09 00:00:00

abstract：:Introduction of DNA fragments, hundreds of kilobases in size, into mouse embryonic stem (ES) cells would greatly advance the ability to manipulate the mouse genome. Mice generated from such modified cells would permit investigation of the function and expression of very large or crudely mapped genes. Large DNA molecul...

journal_title：Nature

authors： Jakobovits A,Moore AL,Green LL,Vergara GJ,Maynard-Currie CE,Austin HA,Klapholz S

更新日期：1993-03-18 00:00:00