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NATURE文献大全abstract::During intracellular Ca2+ signalling mitochondria accumulate significant amounts of Ca2+ from the cytosol. Mitochondrial Ca2+ uptake controls the rate of energy production, shapes the amplitude and spatio-temporal patterns of intracellular Ca2+ signals, and is instrumental to cell death. This Ca2+ uptake is undertaken...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02246
更新日期:2004-01-22 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor. The identificatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365253a0
更新日期:1993-09-16 00:00:00
abstract::The Earth's mantle is isotopically heterogeneous on length scales ranging from centimetres to more than 10(4) kilometres. This heterogeneity originates from partial melt extraction and plate tectonic recycling, whereas stirring during mantle convection tends to reduce it. Here we show that mid-ocean ridge basalts from...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04582
更新日期:2006-03-09 00:00:00
abstract::Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01209
更新日期:2002-11-28 00:00:00
abstract::Theories of the origin of optical asymmetry in living systems place fundamental importance on the amplification of optical asymmetry by an autocatalytic process. The replication of a polynucleotide is one obvious choice for such an autocatalytic growth mechanism. If an optically homogeneous polynucleotide could replic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310602a0
更新日期:1984-08-16 00:00:00
abstract::RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335375a0
更新日期:1988-09-22 00:00:00
abstract::Long-term depletion of the stratospheric ozone layer contributes to an increase in terrestrial solar ultraviolet-B radiation. This has deleterious effects on living organisms, such as DNA damage. When exposed to elevated ultraviolet-B radiation (UV-B; 280-315 nm), plants display a wide variety of physiological and mor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35017595
更新日期:2000-07-06 00:00:00
abstract::Studies of the actin-based motility of the intracellular pathogens Listeria monocytogenes and Shigella flexneri have provided important insight into the events occurring at the leading edges of motile cells. Like the bacteria Listeria and Shigella, vaccinia virus, a relative of the causative agent of smallpox, uses ac...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/44860
更新日期:1999-10-28 00:00:00
abstract::The hydroxyl radical (OH) is a key oxidant involved in the removal of air pollutants and greenhouse gases from the atmosphere. The ratio of Northern Hemispheric to Southern Hemispheric (NH/SH) OH concentration is important for our understanding of emission estimates of atmospheric species such as nitrogen oxides and m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13721
更新日期:2014-09-11 00:00:00
abstract::DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (P...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13923
更新日期:2015-02-12 00:00:00
abstract::The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346060a0
更新日期:1990-07-05 00:00:00
abstract::Fast radio bursts (FRBs) are millisecond-duration radio transients1,2 of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star magnetospheres3-5 or relativistic shocks far from the central energy source6-8. Detailed polarization observations may help us t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2827-2
更新日期:2020-10-01 00:00:00
abstract::An analysis of 15 protein structures indicates: First, the loss of accessible surface area by monomeric proteins on folding-proportional to hydrophobic energy-is a simple function of molecular weight; second, the proportion of polar groups forming intramolecular hydrogen bonds is constant; and third, protein interiors...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/254304a0
更新日期:1975-03-27 00:00:00
abstract::According to the generally accepted scenario, the last giant impact on Earth formed the Moon and initiated the final phase of core formation by melting Earth's mantle. A key goal of geochemistry is to date this event, but different ages have been proposed. Some argue for an early Moon-forming event, approximately 30 m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13172
更新日期:2014-04-03 00:00:00
abstract::Palaeomagnetic measurements of meteorites suggest that, shortly after the birth of the Solar System, the molten metallic cores of many small planetary bodies convected vigorously and were capable of generating magnetic fields. Convection on these bodies is currently thought to have been thermally driven, implying that...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14114
更新日期:2015-01-22 00:00:00
abstract::Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/303256a0
更新日期:1983-05-19 00:00:00
abstract::There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...
journal_title:Nature
pub_type: 社论
doi:10.1038/374663a0
更新日期:1995-04-20 00:00:00
abstract::During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317449a0
更新日期:1985-10-03 00:00:00
abstract::Neuromorphic computing draws inspiration from the brain to provide computing technology and architecture with the potential to drive the next wave of computer engineering1-13. Such brain-inspired computing also provides a promising platform for the development of artificial general intelligence14,15. However, unlike c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2782-y
更新日期:2020-10-01 00:00:00
abstract::The motility of the gastrointestinal tract consists of local, non-propulsive mixing (pendular or segmental) and propulsive (peristaltic) movements. It is generally considered that mixing movements are produced by intrinsic pacemakers which generate rhythmic contractions, and peristalsis by intrinsic excitatory and inh...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/19973
更新日期:1999-05-06 00:00:00
abstract::Activity-induced changes in the efficacy of synaptic transmission between neurones are central to several prominent theories of learning. In both in vivo and in vitro preparations of the hippocampus, a conditioning high-frequency stimulus delivered to afferent fibres results in a long-term potentiation of synaptic tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320529a0
更新日期:1986-04-10 00:00:00
abstract::Chemical reactions inside single crystals are likely to be highly selective, but examples of single crystal to single crystal (SC-SC) transformations are uncommon, because crystallinity is difficult to retain following the rearrangement of atoms in the solid state. The most widely studied SC-SC transformations involve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09085
更新日期:2010-06-03 00:00:00
abstract::The alternative non-homologous end-joining (NHEJ) machinery facilitates several genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fusions. Using next-generatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14157
更新日期:2015-02-12 00:00:00
abstract::From drug delivery to chemical and biological catalysis and cosmetics, the need for efficient fabrication pathways for particles over a wide range of sizes, from a variety of materials, and in many different structures has been well established. Here we harness the inherent scalability of fibre production and an in-fi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11215
更新日期:2012-07-26 00:00:00
abstract::Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339073a0
更新日期:1989-05-04 00:00:00
abstract::Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11836
更新日期:2013-02-21 00:00:00
abstract::Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0497-0
更新日期:2018-09-01 00:00:00
abstract::The polypeptide chains that make up proteins have thousands of atoms and hence millions of possible inter-atomic interactions. It might be supposed that the resulting complexity would make prediction of protein structure and protein-folding mechanisms nearly impossible. But the fundamental physics underlying folding m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35011000
更新日期:2000-05-04 00:00:00
abstract::The first event in the initiation of an immune response is the capture and presentation of antigen to T cells. Such presentation involves two distinct steps: (1) display of the antigen, which requires uptake, processing and re-expression of the antigen in association with MHC molecules on the presenting cell surface; ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334253a0
更新日期:1988-07-21 00:00:00
abstract::Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05530
更新日期:2007-03-01 00:00:00