A surprising simplicity to protein folding.

abstract：:Mitochondria, organelles specialized in energy conservation reactions in eukaryotic cells, have evolved from eubacteria-like endosymbionts whose closest known relatives are the rickettsial group of alpha-proteobacteria. Because characterized mitochondrial genomes vary markedly in structure, it has been impossible to i...

journal_title：Nature

authors： Lang BF,Burger G,O'Kelly CJ,Cedergren R,Golding GB,Lemieux C,Sankoff D,Turmel M,Gray MW

更新日期：1997-05-29 00:00:00

abstract：:With only a few exceptions that are well understood, conventional superconductivity does not coexist with long-range magnetic order (for example, ref. 1). Unconventional superconductivity, on the other hand, develops near a phase boundary separating magnetically ordered and magnetically disordered phases. A maximum in...

journal_title：Nature

authors： Park T,Ronning F,Yuan HQ,Salamon MB,Movshovich R,Sarrao JL,Thompson JD

更新日期：2006-03-02 00:00:00

abstract：:Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopam...

journal_title：Nature

authors： Sunahara RK,Niznik HB,Weiner DM,Stormann TM,Brann MR,Kennedy JL,Gelernter JE,Rozmahel R,Yang YL,Israel Y

更新日期：1990-09-06 00:00:00

abstract：:Three subfamilies of grasses, the Ehrhartoideae, Panicoideae and Pooideae, provide the bulk of human nutrition and are poised to become major sources of renewable energy. Here we describe the genome sequence of the wild grass Brachypodium distachyon (Brachypodium), which is, to our knowledge, the first member of the P...

journal_title：Nature

authors： International Brachypodium Initiative.

更新日期：2010-02-11 00:00:00

abstract：:The 3-A structure of DNA-binding protein II, which exhibits histone-like properties in bacteria, has been determined. The molecule is dimeric and appears to bind to the phosphate backbone of DNA through two symmetry-related arms. A mechanism by which the protein induces DNA supercoiling is proposed. ...

journal_title：Nature

authors： Tanaka I,Appelt K,Dijk J,White SW,Wilson KS

更新日期：1984-08-02 00:00:00

abstract：:Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lnc...

journal_title：Nature

authors： Necsulea A,Soumillon M,Warnefors M,Liechti A,Daish T,Zeller U,Baker JC,Grützner F,Kaessmann H

更新日期：2014-01-30 00:00:00

abstract：:Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...

journal_title：Nature

authors： Reed DA,Keitz BK,Oktawiec J,Mason JA,Runčevski T,Xiao DJ,Darago LE,Crocellà V,Bordiga S,Long JR

更新日期：2017-10-05 00:00:00

abstract：:Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is ver...

journal_title：Nature

authors： McLean JW,Tomlinson JE,Kuang WJ,Eaton DL,Chen EY,Fless GM,Scanu AM,Lawn RM

更新日期：1987-11-12 00:00:00

abstract：:Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...

journal_title：Nature

authors： Gardner AS,Moholdt G,Wouters B,Wolken GJ,Burgess DO,Sharp MJ,Cogley JG,Braun C,Labine C

更新日期：2011-05-19 00:00:00

abstract：:Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP...

journal_title：Nature

authors： Ray Chaudhuri A,Callen E,Ding X,Gogola E,Duarte AA,Lee JE,Wong N,Lafarga V,Calvo JA,Panzarino NJ,John S,Day A,Crespo AV,Shen B,Starnes LM,de Ruiter JR,Daniel JA,Konstantinopoulos PA,Cortez D,Cantor SB,Fernandez-Ca

更新日期：2016-07-21 00:00:00

abstract：:The Yorkie homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif, also known as WWTR1), effectors of the Hippo pathway, have been identified as mediators for mechanical stimuli. However, the role of YAP/TAZ in haemodynamics-induced mechanotransduction and pathogenesis of a...

journal_title：Nature

authors： Wang L,Luo JY,Li B,Tian XY,Chen LJ,Huang Y,Liu J,Deng D,Lau CW,Wan S,Ai D,Mak KK,Tong KK,Kwan KM,Wang N,Chiu JJ,Zhu Y,Huang Y

更新日期：2016-12-22 00:00:00

abstract：:The observations that atherosclerosis often occurs in non-smokers without elevated levels of low-density lipoprotein cholesterol, and that most atherosclerosis loci so far identified in mice do not affect systemic risk factors associated with atherosclerosis, suggest that as-yet-unidentified mechanisms must contribute...

journal_title：Nature

authors： Bernal-Mizrachi C,Gates AC,Weng S,Imamura T,Knutsen RH,DeSantis P,Coleman T,Townsend RR,Muglia LJ,Semenkovich CF

更新日期：2005-05-26 00:00:00

abstract：:Since 1814, when rubella was first described, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus), have remained unclear1. Here we describe ruhugu virus and rustrela virus in Africa and Europe, respectively, which are, to our knowledge, the first known relatives of rubella viru...

journal_title：Nature

authors： Bennett AJ,Paskey AC,Ebinger A,Pfaff F,Priemer G,Höper D,Breithaupt A,Heuser E,Ulrich RG,Kuhn JH,Bishop-Lilly KA,Beer M,Goldberg TL

更新日期：2020-10-01 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00

abstract：:Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct out...

journal_title：Nature

authors： Djebali S,Davis CA,Merkel A,Dobin A,Lassmann T,Mortazavi A,Tanzer A,Lagarde J,Lin W,Schlesinger F,Xue C,Marinov GK,Khatun J,Williams BA,Zaleski C,Rozowsky J,Röder M,Kokocinski F,Abdelhamid RF,Alioto T,Antoshechkin

更新日期：2012-09-06 00:00:00

abstract：:The origins of the building blocks of the Solar System can be studied using the isotopic composition of early planetary and meteoritic material. Oxygen isotopes in planetary materials show variations at the per cent level that are not related to the mass of the isotopes; rather, they result from the mixture of compone...

journal_title：Nature

authors： Aléon J,Robert F,Duprat J,Derenne S

更新日期：2005-09-15 00:00:00

abstract：:Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified th...

journal_title：Nature

authors： Wetzel C,Hu J,Riethmacher D,Benckendorff A,Harder L,Eilers A,Moshourab R,Kozlenkov A,Labuz D,Caspani O,Erdmann B,Machelska H,Heppenstall PA,Lewin GR

更新日期：2007-01-11 00:00:00

abstract：:The generation of a double-strand break in the Saccharomyces cerevisiae genome is a potentially catastrophic event that can induce cell-cycle arrest or ultimately result in loss of cell viability. The repair of such lesions is strongly dependent on proteins encoded by the RAD52 epistasis group of genes (RAD50-55, RAD5...

journal_title：Nature

authors： New JH,Sugiyama T,Zaitseva E,Kowalczykowski SC

更新日期：1998-01-22 00:00:00

abstract：:Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are common substances of abuse. Without reliable structural data, the mechanist...

journal_title：Nature

authors： Masiulis S,Desai R,Uchański T,Serna Martin I,Laverty D,Karia D,Malinauskas T,Zivanov J,Pardon E,Kotecha A,Steyaert J,Miller KW,Aricescu AR

更新日期：2019-01-01 00:00:00

abstract：:A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...

journal_title：Nature

authors： Vogel AB,Kanevsky I,Che Y,Swanson KA,Muik A,Vormehr M,Kranz LM,Walzer KC,Hein S,Güler A,Loschko J,Maddur MS,Ota-Setlik A,Tompkins K,Cole J,Lui BG,Ziegenhals T,Plaschke A,Eisel D,Dany SC,Fesser S,Erbar S,Bates

更新日期：2021-02-01 00:00:00

abstract：:Templates are widely used to arrange molecular components so they can be covalently linked into complex molecules that are not readily accessible by classical synthetic methods. Nature uses sophisticated templates such as the ribosome, whereas chemists use simple ions or small molecules. But as we tackle the synthesis...

journal_title：Nature

authors： O'Sullivan MC,Sprafke JK,Kondratuk DV,Rinfray C,Claridge TD,Saywell A,Blunt MO,O'Shea JN,Beton PH,Malfois M,Anderson HL

更新日期：2011-01-06 00:00:00

abstract：:In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...

journal_title：Nature

authors： Matsumoto S,Cavadini S,Bunker RD,Grand RS,Potenza A,Rabl J,Yamamoto J,Schenk AD,Schübeler D,Iwai S,Sugasawa K,Kurumizaka H,Thomä NH

更新日期：2019-07-01 00:00:00

abstract：:The vertical structure of the recent Arctic warming contains information about the processes governing Arctic climate trends. Graversen et al. argue, on the basis of ERA-40 reanalysis data, that a distinct maximum in 1979-2001 warm-season (April-October) Arctic temperature trends appears around 3 km above ground. Here...

journal_title：Nature

authors： Grant AN,Brönnimann S,Haimberger L

更新日期：2008-09-11 00:00:00

abstract：:An increase in free calcium triggers catecholamine secretion from chromaffin cells and calmodulin is strongly implicated as the intracellular Ca2+ receptor. In our recent studies of calmodulin action in the chromaffin cell, micromolar Ca2+ concentrations resulted in calmodulin and cytosolic proteins becoming bound to ...

journal_title：Nature

authors： Geisow MJ,Burgoyne RD

更新日期：1983-02-03 00:00:00

abstract：:Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...

journal_title：Nature

authors： Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,Yu Q,Aichler M,Walch A,Mirastschijski U,Volz T,Rinkevich Y

更新日期：2019-12-01 00:00:00

abstract：:The global land and ocean carbon sinks have increased proportionally with increasing carbon dioxide emissions during the past decades1. It is thought that Northern Hemisphere lands make a dominant contribution to the global land carbon sink2-7; however, the long-term trend of the northern land sink remains uncertain. ...

journal_title：Nature

authors： Ciais P,Tan J,Wang X,Roedenbeck C,Chevallier F,Piao SL,Moriarty R,Broquet G,Le Quéré C,Canadell JG,Peng S,Poulter B,Liu Z,Tans P

更新日期：2019-04-01 00:00:00

abstract：:Bottom trawling is a non-selective commercial fishing technique whereby heavy nets and gear are pulled along the sea floor. The direct impact of this technique on fish populations and benthic communities has received much attention, but trawling can also modify the physical properties of seafloor sediments, water–sedi...

journal_title：Nature

authors： Puig P,Canals M,Company JB,Martín J,Amblas D,Lastras G,Palanques A

更新日期：2012-09-13 00:00:00

abstract：:Clathrin is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of M(r) approximately 100,000 (100K) in lysates of different mammalian cells. Formation of th...

journal_title：Nature

authors： Pleasure IT,Black MM,Keen JH

更新日期：1993-09-30 00:00:00

abstract：:De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein o...

journal_title：Nature

authors： Ng AH,Nguyen TH,Gómez-Schiavon M,Dods G,Langan RA,Boyken SE,Samson JA,Waldburger LM,Dueber JE,Baker D,El-Samad H

更新日期：2019-08-01 00:00:00

abstract：:The diverse functions of RNA, which include enzymatic activities, regulatory roles in transcription and translation, are made possible by tertiary structure. Computer algorithms can predict the secondary structure of an RNA molecule using free-energy parameters for base pairing and stacking, loops and bulges. However,...

journal_title：Nature

authors： Puglisi JD,Wyatt JR,Tinoco I Jr

更新日期：1988-01-21 00:00:00