3-A resolution structure of a protein with histone-like properties in prokaryotes.

abstract：:In this Letter, errors in Supplementary Table 1 have been corrected. ...

journal_title：Nature

authors： Song XP,Hansen MC,Stehman SV,Potapov PV,Tyukavina A,Vermote EF,Townshend JR

更新日期：2018-11-01 00:00:00

abstract：:The central nervous system (CNS) requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for neural function. This environment is maintained by the 'blood-brain barrier' (BBB), which is composed of blood vessels whose endothelial cells display specialized tight...

journal_title：Nature

authors： Ben-Zvi A,Lacoste B,Kur E,Andreone BJ,Mayshar Y,Yan H,Gu C

更新日期：2014-05-22 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature19356. ...

journal_title：Nature

authors： Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie Helmut Fuc

更新日期：2017-11-16 00:00:00

abstract：:The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders1-4. Here we show that the assembly of the viral community in neonates takes place in distinct steps. Fluorescent staining of virus-like particles purified from...

journal_title：Nature

authors： Liang G,Zhao C,Zhang H,Mattei L,Sherrill-Mix S,Bittinger K,Kessler LR,Wu GD,Baldassano RN,DeRusso P,Ford E,Elovitz MA,Kelly MS,Patel MZ,Mazhani T,Gerber JS,Kelly A,Zemel BS,Bushman FD

更新日期：2020-05-01 00:00:00

abstract：:The cyc- variants of S49 lymphoma cells have served as powerful tools for studying the components and mechanisms of hormone-induced adenylate cyclase stimulation, as these cells are deficient in the guanine nucleotide regulatory site (Ns) mediating hormone, guanine nucleotide, cholera toxin and fluoride-induced stimul...

journal_title：Nature

authors： Jakobs KH,Aktories K,Schultz G

更新日期：1983-05-12 00:00:00

abstract：:Butterflies rely extensively on colour vision to adapt to the natural world. Most species express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eyes), which are distributed stochastically across the retina. The retinas of Drosophila melanogaster use just two main types, in whic...

journal_title：Nature

authors： Perry M,Kinoshita M,Saldi G,Huo L,Arikawa K,Desplan C

更新日期：2016-07-14 00:00:00

abstract：:High-pressure transitions are thought to modify hydrogen molecules to a molecular metallic solid and finally to an atomic metal1, which is predicted to have exotic physical properties and the topology of a two-component (electron and proton) superconducting superfluid condensate2,3. Therefore, understanding such trans...

journal_title：Nature

authors： Ji C,Li B,Liu W,Smith JS,Majumdar A,Luo W,Ahuja R,Shu J,Wang J,Sinogeikin S,Meng Y,Prakapenka VB,Greenberg E,Xu R,Huang X,Yang W,Shen G,Mao WL,Mao HK

更新日期：2019-09-01 00:00:00

abstract：:The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

journal_title：Nature

authors： Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

更新日期：1986-09-25 00:00:00

abstract：:The variable regions of mouse kappa (kappa) chains are coded for by multiple variable (V) gene segments and multiple joining (J) gene segments. The V kappa gene segments code for residues 1 to 95; the J kappa gene segments code for residues 96 to 108 (refs 1-3). This gene organisation is similar to that encoding the V...

journal_title：Nature

authors： Weigert M,Perry R,Kelley D,Hunkapiller T,Schilling J,Hood L

更新日期：1980-01-31 00:00:00

abstract：:In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent inducti...

journal_title：Nature

authors： Rodríguez Esteban C,Capdevila J,Economides AN,Pascual J,Ortiz A,Izpisúa Belmonte JC

更新日期：1999-09-16 00:00:00

abstract：:Knowledge of the composition of the Earth's core is important for understanding its melting point and therefore the temperature at the inner-core boundary and the temperature profile of the core and mantle. In addition, the partitioning of light elements between solid and liquid, as the outer core freezes at the inner...

journal_title：Nature

authors： Alfe D,Gillan MJ,Price GD

更新日期：2000-05-11 00:00:00

abstract：:The electronic properties of heterostructures of atomically thin van der Waals crystals can be modified substantially by moiré superlattice potentials from an interlayer twist between crystals1,2. Moiré tuning of the band structure has led to the recent discovery of superconductivity3,4 and correlated insulating phase...

journal_title：Nature

authors： Kerelsky A,McGilly LJ,Kennes DM,Xian L,Yankowitz M,Chen S,Watanabe K,Taniguchi T,Hone J,Dean C,Rubio A,Pasupathy AN

更新日期：2019-08-01 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00

abstract：:Activity-dependent change in the efficacy of transmission is a basic feature of many excitatory synapses in the central nervous system. The best understood postsynaptic modification involves a change in responsiveness of AMPAR (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor)-mediated currents follo...

journal_title：Nature

authors： Liu SQ,Cull-Candy SG

更新日期：2000-05-25 00:00:00

abstract：:Gap junction channels are structurally distinct from other ion channels in that they comprise two hemichannels which interact head-to-head to form an aqueous channel between cells. Intercellular voltage differences together with increased intracellular concentrations of H+ and Ca2+ cause closure of these normally pate...

journal_title：Nature

authors： Suchyna TM,Xu LX,Gao F,Fourtner CR,Nicholson BJ

更新日期：1993-10-28 00:00:00

abstract：:To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...

journal_title：Nature

authors： Ganeshram RS,Pedersen TF,Calvert S,François R

更新日期：2002-01-10 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory1,2. Although the importance of regions such as the ventral tegmental area3,4 and locus coeruleus5 in broa...

journal_title：Nature

authors： Chen S,He L,Huang AJY,Boehringer R,Robert V,Wintzer ME,Polygalov D,Weitemier AZ,Tao Y,Gu M,Middleton SJ,Namiki K,Hama H,Therreau L,Chevaleyre V,Hioki H,Miyawaki A,Piskorowski RA,McHugh TJ

更新日期：2020-10-01 00:00:00

abstract：:Copy number variants (CNVs) are major contributors to genetic disorders. We have dissected a region of the 16p11.2 chromosome--which encompasses 29 genes--that confers susceptibility to neurocognitive defects when deleted or duplicated. Overexpression of each human transcript in zebrafish embryos identified KCTD13 as ...

journal_title：Nature

authors： Golzio C,Willer J,Talkowski ME,Oh EC,Taniguchi Y,Jacquemont S,Reymond A,Sun M,Sawa A,Gusella JF,Kamiya A,Beckmann JS,Katsanis N

更新日期：2012-05-16 00:00:00

abstract：:The silicate Earth is strongly depleted in moderately volatile elements (such as lead, zinc, indium and alkali elements) relative to CI chondrites, the meteorites that compositionally most closely resemble the Sun. This depletion may be explained qualitatively by accretion of 10 to 20 per cent of a volatile-rich body ...

journal_title：Nature

authors： Norris CA,Wood BJ

更新日期：2017-09-27 00:00:00

abstract：:Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin1-3. Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cycl...

journal_title：Nature

authors： Hellmuth S,Gómez-H L,Pendás AM,Stemmann O

更新日期：2020-04-01 00:00:00

abstract：:Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...

journal_title：Nature

authors： Lassance JM,Groot AT,Liénard MA,Antony B,Borgwardt C,Andersson F,Hedenström E,Heckel DG,Löfstedt C

更新日期：2010-07-22 00:00:00

abstract：:The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...

journal_title：Nature

authors： Zecević D

更新日期：1996-05-23 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00

abstract：:Although the first ten million years of whale evolution are documented by a remarkable series of fossil skeletons, the link to the ancestor of cetaceans has been missing. It was known that whales are related to even-toed ungulates (artiodactyls), but until now no artiodactyls were morphologically close to early whales...

journal_title：Nature

authors： Thewissen JG,Cooper LN,Clementz MT,Bajpai S,Tiwari BN

更新日期：2007-12-20 00:00:00

abstract：:The shape of the human erythrocyte depends on intracellular ATP content and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape after incubation at 37 degrees C; however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of...

journal_title：Nature

authors： Jinbu Y,Sato S,Nakao M

更新日期：1984-01-26 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:Despite tremendous efforts, development of an effective vaccine against human immunodeficiency virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies have been identified that are capable of neutralizing most circulating HIV strains. These antibodies all exhibit an unusually high level of somat...

journal_title：Nature

authors： Balazs AB,Chen J,Hong CM,Rao DS,Yang L,Baltimore D

更新日期：2011-11-30 00:00:00

abstract：:Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie phenotypic variation. Moreover, wild strains of the plant Arabidopsis thaliana differ in many epialleles, and these can influence the expression of nearby genes. However, to understand their role in evolution, it is imperative ...

journal_title：Nature

authors： Becker C,Hagmann J,Müller J,Koenig D,Stegle O,Borgwardt K,Weigel D

更新日期：2011-09-20 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experiments with hypertens...

journal_title：Nature

authors： Krege JH,John SW,Langenbach LL,Hodgin JB,Hagaman JR,Bachman ES,Jennette JC,O'Brien DA,Smithies O

更新日期：1995-05-11 00:00:00