KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant.

abstract：:For more than 140 years, pollen tube guidance in flowering plants has been thought to be mediated by chemoattractants derived from target ovules. However, there has been no convincing evidence of any particular molecule being the true attractant that actually controls the navigation of pollen tubes towards ovules. Eme...

journal_title：Nature

authors： Okuda S,Tsutsui H,Shiina K,Sprunck S,Takeuchi H,Yui R,Kasahara RD,Hamamura Y,Mizukami A,Susaki D,Kawano N,Sakakibara T,Namiki S,Itoh K,Otsuka K,Matsuzaki M,Nozaki H,Kuroiwa T,Nakano A,Kanaoka MM,Dresselhaus T,Sa

更新日期：2009-03-19 00:00:00

abstract：:Metamaterials are artificial optical media composed of sub-wavelength metallic and dielectric building blocks that feature optical phenomena not present in naturally occurring materials. Although they can serve as the basis for unique optical devices that mould the flow of light in unconventional ways, three-dimension...

journal_title：Nature

authors： High AA,Devlin RC,Dibos A,Polking M,Wild DS,Perczel J,de Leon NP,Lukin MD,Park H

更新日期：2015-06-11 00:00:00

abstract：:Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a si...

journal_title：Nature

authors： Moses K,Ellis MC,Rubin GM

更新日期：1989-08-17 00:00:00

abstract：:Splicing of the Tetrahymena ribosomal intron was first studied by Cech et al., who subsequently demonstrated that the intron RNA catalyses its own excision from a primary transcript to yield mature ribosomal RNA. This intron shares several short conserved sequences and a common secondary structure with several other i...

journal_title：Nature

authors： Szostak JW

更新日期：1986-07-03 00:00:00

abstract：:Interleukin-5 (IL-5) specifically induces the differentiation of eosinophils, which are important in host defence and the pathogenesis of allergies and asthma. Structurally, IL-5 is a unique member of the short-chain helical-bundle subfamily of cytokines whose canonical motif contains four helices (A-D) arranged in an...

journal_title：Nature

authors： Dickason RR,Huston DP

更新日期：1996-02-15 00:00:00

abstract：:Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...

journal_title：Nature

authors： Hynes TR,Kautz RA,Goodman MA,Gill JF,Fox RO

更新日期：1989-05-04 00:00:00

abstract：:The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...

journal_title：Nature

authors： Durbin R,Willshaw D

更新日期：1987-04-16 00:00:00

abstract：:Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis1. GABAB belongs to class C of the G-protein-coupled receptors, and its functional entity...

journal_title：Nature

authors： Shaye H,Ishchenko A,Lam JH,Han GW,Xue L,Rondard P,Pin JP,Katritch V,Gati C,Cherezov V

更新日期：2020-08-01 00:00:00

abstract：:Metastasis is a major cause of death in cancer patients and involves a multistep process including detachment of cancer cells from a primary cancer, invasion of surrounding tissue, spread through circulation, re-invasion and proliferation in distant organs. KiSS-1 is a human metastasis suppressor gene, that suppresses...

journal_title：Nature

authors： Ohtaki T,Shintani Y,Honda S,Matsumoto H,Hori A,Kanehashi K,Terao Y,Kumano S,Takatsu Y,Masuda Y,Ishibashi Y,Watanabe T,Asada M,Yamada T,Suenaga M,Kitada C,Usuki S,Kurokawa T,Onda H,Nishimura O,Fujino M

更新日期：2001-05-31 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:A plume of water vapour escapes from fissures crossing the south polar region of the Saturnian moon Enceladus. Tidal deformation of a thin surface crust above an internal ocean could result in tensile and compressive stresses that would affect the width of the fissures; therefore, the quantity of water vapour released...

journal_title：Nature

authors： Hansen CJ,Esposito LW,Stewart AI,Meinke B,Wallis B,Colwell JE,Hendrix AR,Larsen K,Pryor W,Tian F

更新日期：2008-11-27 00:00:00

abstract：:Despite decades of research, the identity of the cells generating the first haematopoietic cells in mammalian embryos is unknown. Indeed, whether blood cells arise from mesodermal cells, mesenchymal progenitors, bipotent endothelial-haematopoietic precursors or haemogenic endothelial cells remains controversial. Proxi...

journal_title：Nature

authors： Eilken HM,Nishikawa S,Schroeder T

更新日期：2009-02-12 00:00:00

abstract：:Over the past eight hundred thousand years, glacial-interglacial cycles oscillated with a period of one hundred thousand years ('100k world'1). Ice core and ocean sediment data have shown that atmospheric carbon dioxide, Antarctic temperature, deep ocean temperature, and global ice volume correlated strongly with each...

journal_title：Nature

authors： Yan Y,Bender ML,Brook EJ,Clifford HM,Kemeny PC,Kurbatov AV,Mackay S,Mayewski PA,Ng J,Severinghaus JP,Higgins JA

更新日期：2019-10-01 00:00:00

abstract：:Cysticercosis caused by larval tapeworms is a major public health problem and a cause of substantial economic losses in the farm-animal industries. Taenia ovis in sheep is a particularly important example. Immunity to reinfection with the larvae has a central role in regulating natural transmission of the parasites, a...

journal_title：Nature

authors： Johnson KS,Harrison GB,Lightowlers MW,O'Hoy KL,Cougle WG,Dempster RP,Lawrence SB,Vinton JG,Heath DD,Rickard MD

更新日期：1989-04-13 00:00:00

abstract：:Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,...

journal_title：Nature

authors： Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs

更新日期：2016-09-22 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Secretory antibodies of the IgA class (sIgA) are thought to have an important role in the defence against bacteria at mucosal surfaces--the level at which the infectious agents first come into contact with the host. However, the mechanism by which sIgA exert their antibacterial activity is still a matter of debate. Af...

journal_title：Nature

authors： Tagliabue A,Nencioni L,Villa L,Keren DF,Lowell GH,Boraschi D

更新日期：1983-11-10 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...

journal_title：Nature

authors： Inoue I,Nagase H,Kishi K,Higuti T

更新日期：1991-07-18 00:00:00

abstract：:The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metaboli...

journal_title：Nature

authors： He S,Kahles F,Rattik S,Nairz M,McAlpine CS,Anzai A,Selgrade D,Fenn AM,Chan CT,Mindur JE,Valet C,Poller WC,Halle L,Rotllan N,Iwamoto Y,Wojtkiewicz GR,Weissleder R,Libby P,Fernández-Hernando C,Drucker DJ,Nahrendorf

更新日期：2019-02-01 00:00:00

abstract：:Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...

journal_title：Nature

authors：

更新日期：1984-07-26 00:00:00

abstract：:In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...

journal_title：Nature

authors： Payre F,Vincent A,Carreno S

更新日期：1999-07-15 00:00:00

abstract：:The purified p21src protein of Harvey sarcoma virus shows a guanine nucleotide-binding activity and, in addition, at elevated temperature an autophosphorylating activity at a threonine residue using as phosphoryl donor GTP or dGTP but not ATP or dATP. These biochemical activities are unique among those associated with...

journal_title：Nature

authors： Shih TY,Papageorge AG,Stokes PE,Weeks MO,Scolnick EM

更新日期：1980-10-23 00:00:00

abstract：:In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...

journal_title：Nature

authors： Andersen TG,Naseer S,Ursache R,Wybouw B,Smet W,De Rybel B,Vermeer JEM,Geldner N

更新日期：2018-07-01 00:00:00

abstract：:Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling repl...

journal_title：Nature

authors： Strick TR,Croquette V,Bensimon D

更新日期：2000-04-20 00:00:00

abstract：:A serine/threonine kinase, named protein kinase B (PKB) for its sequence homology to both protein kinase A and C, has previously been isolated. PKB, which is identical to the kinase Rac, was later found to be the cellular homologue of the transforming v-Akt. Here we show that PKB is activated by stimuli such as insuli...

journal_title：Nature

authors： Burgering BM,Coffer PJ

更新日期：1995-08-17 00:00:00

abstract：:Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and dimethyl marks from lysine 4 of histone H3 (H3K4). In contrast, during ...

journal_title：Nature

authors： Metzger E,Imhof A,Patel D,Kahl P,Hoffmeyer K,Friedrichs N,Müller JM,Greschik H,Kirfel J,Ji S,Kunowska N,Beisenherz-Huss C,Günther T,Buettner R,Schüle R

更新日期：2010-04-01 00:00:00

abstract：:Neptune has five narrow ring arcs, spanning about 40 degrees in longitude, which are apparently confined against the rapid azimuthal and radial spreading that normally results from inter-particle collisions. A gravitational resonance based on the vertical motion of the nearby neptunian moon Galatea was proposed to exp...

journal_title：Nature

authors： Namouni F,Porco C

更新日期：2002-05-02 00:00:00

abstract：:The signature of Dansgaard-Oeschger events--millennial-scale abrupt climate oscillations during the last glacial period--is well established in ice cores and marine records. But the effects of such events in continental settings are not as clear, and their absolute chronology is uncertain beyond the limit of (14)C dat...

journal_title：Nature

authors： Genty D,Blamart D,Ouahdi R,Gilmour M,Baker A,Jouzel J,Van-Exter S

更新日期：2003-02-20 00:00:00

abstract：:ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by...

journal_title：Nature

authors： Pebay-Peyroula E,Dahout-Gonzalez C,Kahn R,Trézéguet V,Lauquin GJ,Brandolin G

更新日期：2003-11-06 00:00:00