Abstract:
:Splicing of the Tetrahymena ribosomal intron was first studied by Cech et al., who subsequently demonstrated that the intron RNA catalyses its own excision from a primary transcript to yield mature ribosomal RNA. This intron shares several short conserved sequences and a common secondary structure with several other introns, some of which have also been shown to self-splice. Here I show that the conserved core of the Tetrahymena intron can act in trans to catalyse the sequence-specific cleavage and addition of guanosine to a separate RNA substrate.
journal_name
Naturejournal_title
Natureauthors
Szostak JWdoi
10.1038/322083a0subject
Has Abstractpub_date
1986-07-03 00:00:00pages
83-6issue
6074eissn
0028-0836issn
1476-4687journal_volume
322pub_type
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