Argentina's mega-storms attract army of meteorologists.

abstract：:Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative disorders caused by an expansion of a polyglutamine tract. It is characterized by ataxia, progressive motor deterioration, and loss of cerebellar Purkinje cells. To understand the pathogenesis of SCA1, we examined the subcellular localization of ...

journal_title：Nature

authors： Skinner PJ,Koshy BT,Cummings CJ,Klement IA,Helin K,Servadio A,Zoghbi HY,Orr HT

更新日期：1997-10-30 00:00:00

abstract：:Nuclear import of the NF-AT transcription factors during T-cell activation requires the calcium-activated phosphatase calcineurin, which unmasks nuclear-location signals on NF-AT. We show here that the nuclear import of NF-ATs is not sufficient to activate NF-AT target genes, as NF-ATs are subject to a futile cycling ...

journal_title：Nature

authors： Zhu J,McKeon F

更新日期：1999-03-18 00:00:00

abstract：:RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy a...

journal_title：Nature

authors： Bernecky C,Herzog F,Baumeister W,Plitzko JM,Cramer P

更新日期：2016-01-28 00:00:00

abstract：:Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) tha...

journal_title：Nature

authors： Martinez-Garcia RI,Voelcker B,Zaltsman JB,Patrick SL,Stevens TR,Connors BW,Cruikshank SJ

更新日期：2020-07-01 00:00:00

abstract：:Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM cells generated by viral infection of the skin differentially ex...

journal_title：Nature

authors： Pan Y,Tian T,Park CO,Lofftus SY,Mei S,Liu X,Luo C,O'Malley JT,Gehad A,Teague JE,Divito SJ,Fuhlbrigge R,Puigserver P,Krueger JG,Hotamisligil GS,Clark RA,Kupper TS

更新日期：2017-03-09 00:00:00

abstract：:Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and even mild alterations in synapse structure drive functional changes during experience-dependent plasticity and pathological disorders. Key to this architecture is how the distribution of presynaptic vesicle fusion sites corresp...

journal_title：Nature

authors： Tang AH,Chen H,Li TP,Metzbower SR,MacGillavry HD,Blanpied TA

更新日期：2016-08-11 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature24277. ...

journal_title：Nature

authors： GTEx Consortium.

更新日期：2018-01-25 00:00:00

abstract：: ...

journal_title：Nature

authors： Clayton EW

更新日期：2018-12-01 00:00:00

abstract：:An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell line...

journal_title：Nature

authors： Kirkwood TB

更新日期：1977-11-24 00:00:00

abstract：:Hydrodynamic flow in classical and quantum fluids can be either laminar or turbulent. Vorticity in turbulent flow is often modelled with vortex filaments. While this represents an idealization in classical fluids, vortices are topologically stable quantized objects in superfluids. Superfluid turbulence is therefore th...

journal_title：Nature

authors： Finne AP,Araki T,Blaauwgeers R,Eltsov VB,Kopnin NB,Krusius M,Skrbek L,Tsubota M,Volovik GE

更新日期：2003-08-28 00:00:00

abstract：: ...

journal_title：Nature

authors： Savage N

更新日期：2018-12-01 00:00:00

abstract：:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

journal_title：Nature

authors： van Houten M,Posner BI

更新日期：1979-12-06 00:00:00

abstract：:Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin1-3. Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cycl...

journal_title：Nature

authors： Hellmuth S,Gómez-H L,Pendás AM,Stemmann O

更新日期：2020-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:The proton-activated chloride channel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell death and tissue injury1-3. PAC has recently been shown to represent a novel and evolutionarily conserved protein family4,5. Here we present two cryo-electron microscopy structures of human...

journal_title：Nature

authors： Ruan Z,Osei-Owusu J,Du J,Qiu Z,Lü W

更新日期：2020-12-01 00:00:00

abstract：:The Earth's mantle is isotopically heterogeneous on length scales ranging from centimetres to more than 10(4) kilometres. This heterogeneity originates from partial melt extraction and plate tectonic recycling, whereas stirring during mantle convection tends to reduce it. Here we show that mid-ocean ridge basalts from...

journal_title：Nature

authors： Graham DW,Blichert-Toft J,Russo CJ,Rubin KH,Albarède F

更新日期：2006-03-09 00:00:00

abstract：:Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...

journal_title：Nature

authors： Pravec P,Vokrouhlický D,Polishook D,Scheeres DJ,Harris AW,Galád A,Vaduvescu O,Pozo F,Barr A,Longa P,Vachier F,Colas F,Pray DP,Pollock J,Reichart D,Ivarsen K,Haislip J,Lacluyze A,Kusnirák P,Henych T,Marchis F,Mac

更新日期：2010-08-26 00:00:00

abstract：:Since 1814, when rubella was first described, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus), have remained unclear1. Here we describe ruhugu virus and rustrela virus in Africa and Europe, respectively, which are, to our knowledge, the first known relatives of rubella viru...

journal_title：Nature

authors： Bennett AJ,Paskey AC,Ebinger A,Pfaff F,Priemer G,Höper D,Breithaupt A,Heuser E,Ulrich RG,Kuhn JH,Bishop-Lilly KA,Beer M,Goldberg TL

更新日期：2020-10-01 00:00:00

abstract：:The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the ...

journal_title：Nature

authors： Havran WL,Allison JP

更新日期：1990-03-01 00:00:00

abstract：:Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence fo...

journal_title：Nature

authors： Squire JM,Freundlich A

更新日期：1980-11-27 00:00:00

abstract：:When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

journal_title：Nature

authors： Lakes RS,Lee T,Bersie A,Wang YC

更新日期：2001-03-29 00:00:00

abstract：:Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone receptor (MC1-R), thus explaining the inhibitory effect of ag...

journal_title：Nature

authors： Fan W,Boston BA,Kesterson RA,Hruby VJ,Cone RD

更新日期：1997-01-09 00:00:00

abstract：:The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates bo...

journal_title：Nature

authors： Hayashi M,Nakashima T,Taniguchi M,Kodama T,Kumanogoh A,Takayanagi H

更新日期：2012-05-03 00:00:00

abstract：:p60src, the transforming protein of Rous sarcoma virus (RSV), is a protein kinase that has a strict specificity for tyrosine. The phosphorylation of cellular proteins by p60src (ref. 4) results in transformation. Recently, Barker and Dayhoff discovered that residues 259-485 of p60src have 22% sequence identity with re...

journal_title：Nature

authors： Kamps MP,Taylor SS,Sefton BM

更新日期：1984-08-16 00:00:00

abstract：:The Redfield ratio of 106 carbon:16 nitrogen:1 phosphorus in marine phytoplankton is one of the foundations of ocean biogeochemistry, with applications in algal physiology, palaeoclimatology and global climate change. However, this ratio varies substantially in response to changes in algal nutrient status and taxonomi...

journal_title：Nature

authors： Sañudo-Wilhelmy SA,Tovar-Sanchez A,Fu FX,Capone DG,Carpenter EJ,Hutchins DA

更新日期：2004-12-16 00:00:00

abstract：:Introduction of DNA fragments, hundreds of kilobases in size, into mouse embryonic stem (ES) cells would greatly advance the ability to manipulate the mouse genome. Mice generated from such modified cells would permit investigation of the function and expression of very large or crudely mapped genes. Large DNA molecul...

journal_title：Nature

authors： Jakobovits A,Moore AL,Green LL,Vergara GJ,Maynard-Currie CE,Austin HA,Klapholz S

更新日期：1993-03-18 00:00:00

abstract：:Reported widespread declines of wild and managed insect pollinators have serious consequences for global ecosystem services and agricultural production. Bees contribute approximately 80% of insect pollination, so it is important to understand and mitigate the causes of current declines in bee populations . Recent stud...

journal_title：Nature

authors： Gill RJ,Ramos-Rodriguez O,Raine NE

更新日期：2012-11-01 00:00:00

abstract：:First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

journal_title：Nature

authors： May RM

更新日期：1976-06-10 00:00:00

abstract：:We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, reveali...

journal_title：Nature

authors： Keane TM,Goodstadt L,Danecek P,White MA,Wong K,Yalcin B,Heger A,Agam A,Slater G,Goodson M,Furlotte NA,Eskin E,Nellåker C,Whitley H,Cleak J,Janowitz D,Hernandez-Pliego P,Edwards A,Belgard TG,Oliver PL,McIntyre RE,

更新日期：2011-09-14 00:00:00

abstract：:Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite ...

journal_title：Nature

authors： Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg V

更新日期：1985-11-07 00:00:00