Erratum: Genetic effects on gene expression across human tissues.

abstract：:T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment1. The function of T cells is tightly regulated by a combinational co-stimulatory signal, and dominance of negative co-stimulation results in T cell dysfunction2. However, the molecular m...

journal_title：Nature

authors： Liu X,Wang Y,Lu H,Li J,Yan X,Xiao M,Hao J,Alekseev A,Khong H,Chen T,Huang R,Wu J,Zhao Q,Wu Q,Xu S,Wang X,Jin W,Yu S,Wang Y,Wei L,Wang A,Zhong B,Ni L,Liu X,Nurieva R,Ye L,Tian Q,Bian XW,Dong C

更新日期：2019-03-01 00:00:00

abstract：:A timescale is necessary for estimating rates of molecular and morphological change in organisms and for interpreting patterns of macroevolution and biogeography. Traditionally, these times have been obtained from the fossil record, where the earliest representatives of two lineages establish a minimum time of diverge...

journal_title：Nature

authors： Kumar S,Hedges SB

更新日期：1998-04-30 00:00:00

abstract：:In the frog Xenopus, the somatic-type 5S ribosomal RNA genes are active in all cells; the oocyte-type 5S genes are active in oocytes but not in somatic cells. A new method of native gel electrophoresis resolves the two types of 5S RNA which are of the same length but different sequence. When somatic nuclei were inject...

journal_title：Nature

authors： Korn LJ,Gurdon JB

更新日期：1981-02-05 00:00:00

abstract：:Transition-metal perovskite oxides exhibit a wide range of extraordinary but imperfectly understood phenomena. The best known examples are high-temperature superconductivity in copper oxides, and colossal magnetoresistance in manganese oxides ('manganites'). All of these materials undergo a range of order-disorder tra...

journal_title：Nature

authors： Renner Ch,Aeppli G,Kim BG,Soh YA,Cheong SW

更新日期：2002-04-04 00:00:00

abstract：:The discovery that atrial extracts have potent diuretic and natriuretic properties revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial na...

journal_title：Nature

authors： Harris PJ,Thomas D,Morgan TO

更新日期：1987-04-16 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...

journal_title：Nature

authors： Park J,Lee SB,Lee S,Kim Y,Song S,Kim S,Bae E,Kim J,Shong M,Kim JM,Chung J

更新日期：2006-06-29 00:00:00

abstract：:The dispute among federal agencies over regulation of commercial biotechnology has been addressed in the Federal Register by the Office of Science and Technology Policy (OSTP), which says the Recombinant DNA Advisory Committee of the National Institutes of Health should continue to oversee biomedical research in this ...

journal_title：Nature

authors： Beardsley T

更新日期：1985-01-10 00:00:00

abstract：:Stable maintenance of gene regulatory programs is essential for normal function in multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are hypothesized to facilitate such maintenance by creating cellular memory that can be written during embryonic development and then guide cell-type-spe...

journal_title：Nature

authors： Shipony Z,Mukamel Z,Cohen NM,Landan G,Chomsky E,Zeliger SR,Fried YC,Ainbinder E,Friedman N,Tanay A

更新日期：2014-09-04 00:00:00

abstract：:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

journal_title：Nature

authors： Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

更新日期：1986-12-04 00:00:00

abstract：:The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Here we have determined three different crystal structures of the extracellular ligand-binding region of mGluR1--in a complex with glutamate and in two unliganded forms. ...

journal_title：Nature

authors： Kunishima N,Shimada Y,Tsuji Y,Sato T,Yamamoto M,Kumasaka T,Nakanishi S,Jingami H,Morikawa K

更新日期：2000-10-26 00:00:00

abstract：:In the HTML version of this Letter, the affiliations for authors Andrew S. Azman, Dhirendra Kumar and Thandavarayan Ramamurthy were inverted (the PDF and print versions of the Letter were correct); the affiliations have been corrected online. ...

journal_title：Nature

authors： Weill FX,Domman D,Njamkepo E,Almesbahi AA,Naji M,Nasher SS,Rakesh A,Assiri AM,Sharma NC,Kariuki S,Pourshafie MR,Rauzier J,Abubakar A,Carter JY,Wamala JF,Seguin C,Bouchier C,Malliavin T,Bakhshi B,Abulmaali HHN,Kuma

更新日期：2019-02-01 00:00:00

abstract：:The widespread reorganization of cellular architecture in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase network and repression of counteracting phosphatases. Phosphatase activity must subsequently be restored to promote mitotic exit. Although Cd...

journal_title：Nature

authors： Grallert A,Boke E,Hagting A,Hodgson B,Connolly Y,Griffiths JR,Smith DL,Pines J,Hagan IM

更新日期：2015-01-01 00:00:00

abstract：:At early stages of the mammalian visual cortex, neurons with similar stimulus selectivities are vertically arrayed through the thickness of the cortical sheet and clustered in patches or bands across the surface. This organization, referred to as a 'column', has been found with respect to one-dimensional stimulus para...

journal_title：Nature

authors： Fujita I,Tanaka K,Ito M,Cheng K

更新日期：1992-11-26 00:00:00

abstract：:The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would p...

journal_title：Nature

authors： Koppens FH,Buizert C,Tielrooij KJ,Vink IT,Nowack KC,Meunier T,Kouwenhoven LP,Vandersypen LM

更新日期：2006-08-17 00:00:00

abstract：:Data from a rocket experiment show details which were not known from ground-based observations. ...

journal_title：Nature

authors： Sudbury GC,Ingham MF

更新日期：1970-05-09 00:00:00

abstract：:The reciprocal chromosome translocation, t(8;14), involving the heavy chain locus on chromosome 14 and the c-myc oncogene on chromosome 8 is a characteristic of the B-cell malignancies Burkitt's lymphoma and acute lymphoblastic leukaemia (ALL). We have cloned and sequenced the t(8; 14) breakpoints of an African Burkit...

journal_title：Nature

authors： Haluska FG,Finver S,Tsujimoto Y,Croce CM

更新日期：1986-11-13 00:00:00

abstract：:Recent theory on sexual selection suggests that females in species without paternal care choose mates by their secondary sexual characters because these indicate genotypic quality which will be transmitted to the offspring. These ideas are not yet empirically supported as data quantifying the relationship between fema...

journal_title：Nature

authors： von Schantz T,Göransson G,Andersson G,Fröberg I,Grahn M,Helgée A,Wittzell H

更新日期：1989-01-12 00:00:00

abstract：:A large number of cis-regulatory sequences have been annotated in the human genome, but defining their target genes remains a challenge. One strategy is to identify the long-range looping interactions at these elements with the use of chromosome conformation capture (3C)-based techniques. However, previous studies lac...

journal_title：Nature

authors： Jin F,Li Y,Dixon JR,Selvaraj S,Ye Z,Lee AY,Yen CA,Schmitt AD,Espinoza CA,Ren B

更新日期：2013-11-14 00:00:00

abstract：:The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the earliest event in the splicing cycle that commits pre-mRNAs to sp...

journal_title：Nature

authors： Li X,Liu S,Zhang L,Issaian A,Hill RC,Espinosa S,Shi S,Cui Y,Kappel K,Das R,Hansen KC,Zhou ZH,Zhao R

更新日期：2019-09-01 00:00:00

abstract：:All synaptically-based neuropsychological theories of learning postulate that there are changes resulting from neural activity which are long-lasting and confined to specific sets of synapses. In the past decade a form of synaptic strengthening known as long-term potentiation (LTP) has been found which results from hi...

journal_title：Nature

authors： Abraham WC,Goddard GV

更新日期：1983-10-20 00:00:00

abstract：:Lymphocyte function-associated antigen-1 (LFA-1) is a heterodimer composed of an alpha and beta chain that is expressed on the surface of most leukocytes and is an essential molecule for adhesion reactions between cells participating in the immune response. A putative ligand for LFA-1 is the intercellular adhesion mol...

journal_title：Nature

authors： van Noesel C,Miedema F,Brouwer M,de Rie MA,Aarden LA,van Lier RA

更新日期：1988-06-30 00:00:00

abstract：:The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...

journal_title：Nature

authors： Durbin R,Willshaw D

更新日期：1987-04-16 00:00:00

abstract：:Increasing human populations around the global coastline have caused extensive loss, degradation and fragmentation of coastal ecosystems, threatening the delivery of important ecosystem services1. As a result, alarming losses of mangrove, coral reef, seagrass, kelp forest and coastal marsh ecosystems have occurred1-6....

journal_title：Nature

authors： Murray NJ,Phinn SR,DeWitt M,Ferrari R,Johnston R,Lyons MB,Clinton N,Thau D,Fuller RA

更新日期：2019-01-01 00:00:00

abstract：:In contrast to microRNAs and Piwi-associated RNAs, short interfering RNAs (siRNAs) are seemingly dispensable for host-directed gene regulation in Drosophila. This notion is based on the fact that mutants lacking the core siRNA-generating enzyme Dicer-2 or the predominant siRNA effector Argonaute 2 are viable, fertile ...

journal_title：Nature

authors： Okamura K,Chung WJ,Ruby JG,Guo H,Bartel DP,Lai EC

更新日期：2008-06-05 00:00:00

abstract：:Ribosome-driven protein biosynthesis is comprised of four phases: initiation, elongation, termination and recycling. In bacteria, ribosome recycling requires ribosome recycling factor and elongation factor G, and several structures of bacterial recycling complexes have been determined. In the eukaryotic and archaeal k...

journal_title：Nature

authors： Becker T,Franckenberg S,Wickles S,Shoemaker CJ,Anger AM,Armache JP,Sieber H,Ungewickell C,Berninghausen O,Daberkow I,Karcher A,Thomm M,Hopfner KP,Green R,Beckmann R

更新日期：2012-02-22 00:00:00

abstract：:Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple ASD risk genes during ...

journal_title：Nature

authors： Parras A,Anta H,Santos-Galindo M,Swarup V,Elorza A,Nieto-González JL,Picó S,Hernández IH,Díaz-Hernández JI,Belloc E,Rodolosse A,Parikshak NN,Peñagarikano O,Fernández-Chacón R,Irimia M,Navarro P,Geschwind DH,Méndez R,L

更新日期：2018-08-01 00:00:00

abstract：:Many voltage-dependent K+ channels open when the membrane is depolarized and then rapidly close by a process called inactivation. Neurons use inactivating K+ channels to modulate their firing frequency. In Shaker-type K+ channels, the inactivation gate, which is responsible for the closing of the channel, is formed by...

journal_title：Nature

authors： Zhou M,Morais-Cabral JH,Mann S,MacKinnon R

更新日期：2001-06-07 00:00:00

abstract：:Framework cavities are the largest but least explored coral reef habitat. Previous dive studies of caverns, spaces below plate corals, rubble and artificial cavities suggest that cavity-dwelling (coelobite) filter-feeders are important in the trophodynamics of reefs. Quantitative community data are lacking, however, a...

journal_title：Nature

authors： Richter C,Wunsch M,Rasheed M,Kötter I,Badran MI

更新日期：2001-10-18 00:00:00

abstract：:The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents for treatment and prevention of acute Ebola virus (EBOV) disease (...

journal_title：Nature

authors： Warren TK,Jordan R,Lo MK,Ray AS,Mackman RL,Soloveva V,Siegel D,Perron M,Bannister R,Hui HC,Larson N,Strickley R,Wells J,Stuthman KS,Van Tongeren SA,Garza NL,Donnelly G,Shurtleff AC,Retterer CJ,Gharaibeh D,Zamani R

更新日期：2016-03-17 00:00:00

abstract：:There is no consensus on whether climate change has yet affected the statistics of tropical cyclones, owing to their large natural variability and the limited period of consistent observations. In addition, projections of future tropical cyclone activity are uncertain, because they often rely on coarse-resolution clim...

journal_title：Nature

authors： Patricola CM,Wehner MF

更新日期：2018-11-01 00:00:00