当前位置： SCI文献检索 > NATURE期刊下所有文献 > Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression.

Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression.

Abstract：

:All synaptically-based neuropsychological theories of learning postulate that there are changes resulting from neural activity which are long-lasting and confined to specific sets of synapses. In the past decade a form of synaptic strengthening known as long-term potentiation (LTP) has been found which results from high-frequency neural activity and is of sufficient duration to model as a learning mechanism. Some early tests of the synaptic specificity of LTP in area CA1 of the hippocampus indicated that although LTP was specific to the tetanized pathway, in a converging untetanized pathway it was associated with depression of synaptic transmission lasting for at least 30 min. However, others have found that this heterosynaptic depression more usually decays within 5-15 min post-tetanus despite the maintenance of LTP in the tetanized pathway. Similarly, in the dentate gyrus (DG), LTP of either the lateral (LPP) or medial (MPP) components of the perforant path afferents has been associated with only short-lasting reciprocal heterosynaptic depression. Here, using more detailed measurement of stimulus intensity curves, we report that tetanization of either MPP or LPP reliably depresses synaptic transmission in the other pathway for at least 3 h. This heterosynaptic depression, considerably smaller than the usual magnitude of LTP, was obtained regardless of whether LTP had been produced in the tetanized homosynaptic pathway. Heterosynaptic long-term depression was not observed if the test pathway had been previously tetanized.

journal_name

Nature

journal_title

Nature

authors

Abraham WC,Goddard GV

doi

10.1038/305717a0

subject

Has Abstract

pub_date

1983-10-20 00:00:00

pages

717-9

issue

5936

eissn

0028-0836

issn

1476-4687

journal_volume

305

pub_type

杂志文章

相关文献

NATURE文献大全
  • The genomic signature of dog domestication reveals adaptation to a starch-rich diet.

    abstract：:The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11837

    authors： Axelsson E,Ratnakumar A,Arendt ML,Maqbool K,Webster MT,Perloski M,Liberg O,Arnemo JM,Hedhammar A,Lindblad-Toh K

    更新日期：2013-03-21 00:00:00

  • Structural basis for action by diverse antidepressants on biogenic amine transporters.

    abstract：:The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs). Because eukaryotic BATs...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12648

    authors： Wang H,Goehring A,Wang KH,Penmatsa A,Ressler R,Gouaux E

    更新日期：2013-11-07 00:00:00

  • El Niño-Southern Oscillation complexity.

    abstract：:El Niño events are characterized by surface warming of the tropical Pacific Ocean and weakening of equatorial trade winds that occur every few years. Such conditions are accompanied by changes in atmospheric and oceanic circulation, affecting global climate, marine and terrestrial ecosystems, fisheries and human activ...

    journal_title：Nature

    pub_type： 杂志文章,评审

    doi：10.1038/s41586-018-0252-6

    authors： Timmermann A,An SI,Kug JS,Jin FF,Cai W,Capotondi A,Cobb KM,Lengaigne M,McPhaden MJ,Stuecker MF,Stein K,Wittenberg AT,Yun KS,Bayr T,Chen HC,Chikamoto Y,Dewitte B,Dommenget D,Grothe P,Guilyardi E,Ham YG,Hayashi M

    更新日期：2018-07-01 00:00:00

  • Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

    abstract：:Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/380072a0

    authors： Nakai J,Dirksen RT,Nguyen HT,Pessah IN,Beam KG,Allen PD

    更新日期：1996-03-07 00:00:00

  • Reconstitution of the tubular endoplasmic reticulum network with purified components.

    abstract：:Organelles display characteristic morphologies that are intimately tied to their cellular function, but how organelles are shaped is poorly understood. The endoplasmic reticulum is particularly intriguing, as it comprises morphologically distinct domains, including a dynamic network of interconnected membrane tubules....

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature21387

    authors： Powers RE,Wang S,Liu TY,Rapoport TA

    更新日期：2017-03-09 00:00:00

  • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.

    abstract：:The lipopolysaccharide (LPS) of Gram negative bacteria is a well-known inducer of the innate immune response. Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common 'pattern' in structurally diverse LPS molecules. To understand the ligand specificity and rece...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature07830

    authors： Park BS,Song DH,Kim HM,Choi BS,Lee H,Lee JO

    更新日期：2009-04-30 00:00:00

  • Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters.

    abstract：:Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/347765a0

    authors： Charpak S,Gähwiler BH,Do KQ,Knöpfel T

    更新日期：1990-10-25 00:00:00

  • A giant stream of metal-rich stars in the halo of the galaxy M31.

    abstract：:Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35083506

    authors： Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

    更新日期：2001-07-05 00:00:00

  • Hinf family: a novel repeated DNA family of the human genome.

    abstract：:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements. ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/302587a0

    authors： Shimizu Y,Yoshida K,Ren CS,Fujinaga K,Rajagopalan S,Chinnadurai G

    更新日期：1983-04-14 00:00:00

  • Avoid brain contamination from surgery.

    abstract：: ...

    journal_title：Nature

    pub_type： 评论,信件

    doi：10.1038/d41586-019-00232-8

    authors： Beekes M,Mielke M,Thomzig A

    更新日期：2019-01-01 00:00:00

  • Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.

    abstract：:The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/290754a0

    authors： Anderson WF,Ohlendorf DH,Takeda Y,Matthews BW

    更新日期：1981-04-30 00:00:00

  • Microscopy of the interacting Harper-Hofstadter model in the two-body limit.

    abstract：:The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature22811

    authors： Tai ME,Lukin A,Rispoli M,Schittko R,Menke T,Dan Borgnia,Preiss PM,Grusdt F,Kaufman AM,Greiner M

    更新日期：2017-06-21 00:00:00

  • Reverse and forward engineering of Drosophila corneal nanocoatings.

    abstract：:Insect eyes have an anti-reflective coating, owing to nanostructures on the corneal surface creating a gradient of refractive index between that of air and that of the lens material1,2. These nanocoatings have also been shown to provide anti-adhesive functionality3. The morphology of corneal nanocoatings are very dive...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2707-9

    authors： Kryuchkov M,Bilousov O,Lehmann J,Fiebig M,Katanaev VL

    更新日期：2020-09-01 00:00:00

  • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.

    abstract：:Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons. Several groups have attributed this apparent plasticity to 'transdifferentiation'. Others, however, have suggested that cell fusion could explain these results...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature02069

    authors： Alvarez-Dolado M,Pardal R,Garcia-Verdugo JM,Fike JR,Lee HO,Pfeffer K,Lois C,Morrison SJ,Alvarez-Buylla A

    更新日期：2003-10-30 00:00:00

  • Sexual selection and the maintenance of sex.

    abstract：:Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35079578

    authors： Siller S,Department of Zoology, University of Oxford, UK. steven.siller@zoo.ox.ac.uk.

    更新日期：2001-06-07 00:00:00

  • Macromolecular diffractive imaging using imperfect crystals.

    abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature16949

    authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

    更新日期：2016-02-11 00:00:00

  • mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

    abstract：:Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, and the current paradigm...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13896

    authors： Faller WJ,Jackson TJ,Knight JR,Ridgway RA,Jamieson T,Karim SA,Jones C,Radulescu S,Huels DJ,Myant KB,Dudek KM,Casey HA,Scopelliti A,Cordero JB,Vidal M,Pende M,Ryazanov AG,Sonenberg N,Meyuhas O,Hall MN,Bushell M,W

    更新日期：2015-01-22 00:00:00

  • A unique regulatory phase of DNA methylation in the early mammalian embryo.

    abstract：:DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so far no base-resoluti...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10960

    authors： Smith ZD,Chan MM,Mikkelsen TS,Gu H,Gnirke A,Regev A,Meissner A

    更新日期：2012-03-28 00:00:00

  • Emergence of vancomycin tolerance in Streptococcus pneumoniae.

    abstract：:Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/21202

    authors： Novak R,Henriques B,Charpentier E,Normark S,Tuomanen E

    更新日期：1999-06-10 00:00:00

  • Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

    abstract：:Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13466

    authors： Goodarzi H,Zhang S,Buss CG,Fish L,Tavazoie S,Tavazoie SF

    更新日期：2014-09-11 00:00:00

  • Structural basis of the activation of a metabotropic GABA receptor.

    abstract：:Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis1. GABAB belongs to class C of the G-protein-coupled receptors, and its functional entity...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2408-4

    authors： Shaye H,Ishchenko A,Lam JH,Han GW,Xue L,Rondard P,Pin JP,Katritch V,Gati C,Cherezov V

    更新日期：2020-08-01 00:00:00

  • Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.

    abstract：:The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/323340a0

    authors： Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

    更新日期：1986-09-25 00:00:00

  • Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies.

    abstract：:The cell adhesion molecules L1, N-CAM and Ng-CAM have been implicated in cell-cell interactions among developing neural cells. L1 and N-CAM are structurally and functionally distinct molecular entities and act synergistically in mediating Ca2+-independent adhesion between re-aggregating early postnatal cerebellar cell...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/316728a0

    authors： Keilhauer G,Faissner A,Schachner M

    更新日期：1985-08-22 00:00:00

  • Active upper-atmosphere chemistry and dynamics from polar circulation reversal on Titan.

    abstract：:Saturn's moon Titan has a nitrogen atmosphere comparable to Earth's, with a surface pressure of 1.4 bar. Numerical models reproduce the tropospheric conditions very well but have trouble explaining the observed middle-atmosphere temperatures, composition and winds. The top of the middle-atmosphere circulation has been...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11611

    authors： Teanby NA,Irwin PG,Nixon CA,de Kok R,Vinatier S,Coustenis A,Sefton-Nash E,Calcutt SB,Flasar FM

    更新日期：2012-11-29 00:00:00

  • Interference among deleterious mutations favours sex and recombination in finite populations.

    abstract：:Sex and recombination are widespread, but explaining these phenomena has been one of the most difficult problems in evolutionary biology. Recombination is advantageous when different individuals in a population carry different advantageous alleles. By bringing together advantageous alleles onto the same chromosome, re...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature05049

    authors： Keightley PD,Otto SP

    更新日期：2006-09-07 00:00:00

  • Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20.

    abstract：:Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/335543a0

    authors： Primakoff P,Lathrop W,Woolman L,Cowan A,Myles D

    更新日期：1988-10-06 00:00:00

  • Short-range control of cell differentiation in the Arabidopsis root meristem.

    abstract：:Meristems are distinctive regions of plants that have capacity for continuous growth. Their developmental activity generates the majority of plant organs. It is currently unknown how cell division and cell differentiation are orchestrated in meristems, although genetic studies have demonstrated the relevance of a prop...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/36856

    authors： van den Berg C,Willemsen V,Hendriks G,Weisbeek P,Scheres B

    更新日期：1997-11-20 00:00:00

  • Radiation-pressure mixing of large dust grains in protoplanetary disks.

    abstract：:Dusty disks around young stars are formed out of interstellar dust that consists of amorphous, submicrometre grains. Yet the grains found in comets and meteorites, and traced in the spectra of young stars, include large crystalline grains that must have undergone annealing or condensation at temperatures in excess of ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature08032

    authors： Vinković D

    更新日期：2009-05-14 00:00:00

  • Structural and biochemical basis of apoptotic activation by Smac/DIABLO.

    abstract：:Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. Here we show t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35022514

    authors： Chai J,Du C,Wu JW,Kyin S,Wang X,Shi Y

    更新日期：2000-08-24 00:00:00

  • Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.

    abstract：:The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent development. Concomitantly, epiblast cells tran...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature24675

    authors： Shahbazi MN,Scialdone A,Skorupska N,Weberling A,Recher G,Zhu M,Jedrusik A,Devito LG,Noli L,Macaulay IC,Buecker C,Khalaf Y,Ilic D,Voet T,Marioni JC,Zernicka-Goetz M

    更新日期：2017-12-14 00:00:00