Abstract：
:The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these regions contain genes important in brain function, eight of which belong to nervous system development pathways and potentially underlie behavioural changes central to dog domestication. Ten genes with key roles in starch digestion and fat metabolism also show signals of selection. We identify candidate mutations in key genes and provide functional support for an increased starch digestion in dogs relative to wolves. Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs.
journal_name
Naturejournal_title
Natureauthors
Axelsson E,Ratnakumar A,Arendt ML,Maqbool K,Webster MT,Perloski M,Liberg O,Arnemo JM,Hedhammar A,Lindblad-Toh Kdoi
10.1038/nature11837subject
Has Abstractpub_date
2013-03-21 00:00:00pages
360-4issue
7441eissn
0028-0836issn
1476-4687pii
nature11837journal_volume
495pub_type
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