Duplication and remoulding of tRNA genes during the evolutionary rearrangement of mitochondrial genomes.

Abstract:

:During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN codons appears to have evolved by duplication and divergence from a tRNA gene specific for another group of leucine codons (UUR, where R is a purine). These proposals account for (1) the strong sequence resemblance between the modern tRNA genes for CUN and UUR codons in Paracentrotus, (2) the altered location of the CUN gene in mitochondrial DNA of this urchin, and (3) the persistence of a 72-base pair sequence containing a trace of the old CUN gene at its original location. The old CUN gene now codes for an extra 24 amino acids at the amino end of subunit 5 in NADH dehydrogenase. Besides giving clues about the mechanisms by which tRNA genes move during mitochondrial DNA evolution, this finding leads us to propose a pathway relating the arrangements of other genes in mitochondrial DNAs from four animal phyla.

journal_name

Nature

journal_title

Nature

authors

Cantatore P,Gadaleta MN,Roberti M,Saccone C,Wilson AC

doi

10.1038/329853a0

subject

Has Abstract

pub_date

1987-10-29 00:00:00

pages

853-5

issue

6142

eissn

0028-0836

issn

1476-4687

journal_volume

329

pub_type

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