Abstract:
:The development of a eutherian mammal as a male is a consequence of testis formation in the embryo, which is thought to be initiated by a gene on the Y chromosome. In the absence of this gene, ovaries are formed and female characteristics develop. Sex determination therefore hinges on the action of this testis-determining gene, known as Tdy in mice and TDF in humans. In the past, several genes proposed as candidates for Tdy/TDF have subsequently been dismissed on the grounds of inappropriate location or expression. We have recently described a candidate for Tdy, which maps to the minimum sex-determining region of the mouse Y chromosome. To examine further the involvement of this gene, Sry, in testis development, we have studied its expression in detail. Fetal expression of Sry is limited to the period in which testes begin to form. This expression is confined to gonadal tissue and does not require the presence of germ cells. Our observations strongly support a primary role for Sry in mouse sex determination.
journal_name
Naturejournal_title
Natureauthors
Koopman P,Münsterberg A,Capel B,Vivian N,Lovell-Badge Rdoi
10.1038/348450a0subject
Has Abstractpub_date
1990-11-29 00:00:00pages
450-2issue
6300eissn
0028-0836issn
1476-4687journal_volume
348pub_type
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