The emergence of transcriptional identity in somatosensory neurons.

Abstract:

:More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess the developmental progression of transcriptional maturation of each subtype of principal somatosensory neuron, we generated a transcriptomic atlas of cells traversing the primary somatosensory neuron lineage in mice. Here we show that somatosensory neurogenesis gives rise to neurons in a transcriptionally unspecialized state, characterized by co-expression of transcription factors that become restricted to select subtypes as development proceeds. Single-cell transcriptomic analyses of sensory neurons from mutant mice lacking transcription factors suggest that these broad-to-restricted transcription factors coordinate subtype-specific gene expression programs in subtypes in which their expression is maintained. We also show that neuronal targets are involved in this process; disruption of the prototypic target-derived neurotrophic factor NGF leads to aberrant subtype-restricted patterns of transcription factor expression. Our findings support a model in which cues that emanate from intermediate and final target fields promote neuronal diversification in part by transitioning cells from a transcriptionally unspecialized state to transcriptionally distinct subtypes by modulating the selection of subtype-restricted transcription factors.

journal_name

Nature

journal_title

Nature

authors

Sharma N,Flaherty K,Lezgiyeva K,Wagner DE,Klein AM,Ginty DD

doi

10.1038/s41586-019-1900-1

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

392-398

issue

7790

eissn

0028-0836

issn

1476-4687

pii

10.1038/s41586-019-1900-1

journal_volume

577

pub_type

杂志文章

相关文献

NATURE文献大全
  • Correlation of structural elements and infectivity of the HET-s prion.

    abstract::Prions are believed to be infectious, self-propagating polymers of otherwise soluble, host-encoded proteins. This concept is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in the corresponding hosts...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03793

    authors: Ritter C,Maddelein ML,Siemer AB,Lührs T,Ernst M,Meier BH,Saupe SJ,Riek R

    更新日期:2005-06-09 00:00:00

  • Experimental determination of entanglement with a single measurement.

    abstract::Nearly all protocols requiring shared quantum information--such as quantum teleportation or key distribution--rely on entanglement between distant parties. However, entanglement is difficult to characterize experimentally. All existing techniques for doing so, including entanglement witnesses or Bell inequalities, dis...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04627

    authors: Walborn SP,Souto Ribeiro PH,Davidovich L,Mintert F,Buchleitner A

    更新日期:2006-04-20 00:00:00

  • Crystal structure of a yeast TFIIA/TBP/DNA complex.

    abstract::The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/381127a0

    authors: Tan S,Hunziker Y,Sargent DF,Richmond TJ

    更新日期:1996-05-09 00:00:00

  • Targeted misexpression of a Drosophila opsin gene leads to altered visual function.

    abstract::Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/333737a0

    authors: Feiler R,Harris WA,Kirschfeld K,Wehrhahn C,Zuker CS

    更新日期:1988-06-23 00:00:00

  • Ecological opportunity and sexual selection together predict adaptive radiation.

    abstract::A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11144

    authors: Wagner CE,Harmon LJ,Seehausen O

    更新日期:2012-07-19 00:00:00

  • Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal.

    abstract::Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of reside...

    journal_title:Nature

    pub_type: 杂志文章,收录出版

    doi:10.1038/345495a0

    authors: Vaux D,Tooze J,Fuller S

    更新日期:1990-06-07 00:00:00

  • Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.

    abstract::Rac signalling to actin -- a pathway that is thought to be mediated by the protein Scar/WAVE (WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein -- has a principal role in cell motility. In an analogous pathway, direct interaction of Cdc42 with the related protein N-WASP stimulates actin polym...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature00859

    authors: Eden S,Rohatgi R,Podtelejnikov AV,Mann M,Kirschner MW

    更新日期:2002-08-15 00:00:00

  • Very mild muscular dystrophy associated with the deletion of 46% of dystrophin.

    abstract::Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), a much milder form of the disease where the age of onset can sometimes be as late as the third or fourth decade of life, are caused by mutations in the same X-linked gene, a 14 kilobase (kb) transcript which is spread over more than 2 megabases of ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/343180a0

    authors: England SB,Nicholson LV,Johnson MA,Forrest SM,Love DR,Zubrzycka-Gaarn EE,Bulman DE,Harris JB,Davies KE

    更新日期:1990-01-11 00:00:00

  • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.

    abstract::Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09529

    authors: Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

    更新日期:2010-11-11 00:00:00

  • Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

    abstract::In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. '. The Article ...

    journal_title:Nature

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41586-019-0883-2

    authors: Nik-Zainal S,Davies H,Staaf J,Ramakrishna M,Glodzik D,Zou X,Martincorena I,Alexandrov LB,Martin S,Wedge DC,Van Loo P,Ju YS,Smid M,Brinkman AB,Morganella S,Aure MR,Lingjærde OC,Langerød A,Ringnér M,Ahn SM,Boyault S

    更新日期:2019-02-01 00:00:00

  • Isolation of a gene regulated by hydrostatic pressure in a deep-sea bacterium.

    abstract::Barophilic bacteria inhabit the deep oceans, and the specific functional modifications and regulatory mechanisms which govern adaptation to hydrostatic pressure are beginning to be understood. For example, the rate of production of several proteins by some hydrothermal vent archaebacteria and the degree of saturation ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/342572a0

    authors: Bartlett D,Wright M,Yayanos AA,Silverman M

    更新日期:1989-11-30 00:00:00

  • Complete quantum control of a single quantum dot spin using ultrafast optical pulses.

    abstract::A basic requirement for quantum information processing systems is the ability to completely control the state of a single qubit. For qubits based on electron spin, a universal single-qubit gate is realized by a rotation of the spin by any angle about an arbitrary axis. Driven, coherent Rabi oscillations between two sp...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07530

    authors: Press D,Ladd TD,Zhang B,Yamamoto Y

    更新日期:2008-11-13 00:00:00

  • Closing yield gaps through nutrient and water management.

    abstract::In the coming decades, a crucial challenge for humanity will be meeting future food demands without undermining further the integrity of the Earth's environmental systems. Agricultural systems are already major forces of global environmental degradation, but population growth and increasing consumption of calorie- and...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11420

    authors: Mueller ND,Gerber JS,Johnston M,Ray DK,Ramankutty N,Foley JA

    更新日期:2012-10-11 00:00:00

  • Functional regeneration of sensory axons into the adult spinal cord.

    abstract::The arrest of dorsal root axonal regeneration at the transitional zone between the peripheral and central nervous system has been repeatedly described since the early twentieth century. Here we show that, with trophic support to damaged sensory axons, this regenerative barrier is surmountable. In adult rats with injur...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35002084

    authors: Ramer MS,Priestley JV,McMahon SB

    更新日期:2000-01-20 00:00:00

  • Animal behaviour: fair refusal by capuchin monkeys.

    abstract::Brosnan and de Waal report that capuchin monkeys show evidence of a sense of fairness or 'inequity aversion' because they rejected a less preferred reward when they saw a partner monkey receive a preferred reward for the same task. However, this does not show that monkeys are averse to inequity, only that they reject ...

    journal_title:Nature

    pub_type: 评论,杂志文章

    doi:10.1038/428140a

    authors: Wynne CD

    更新日期:2004-03-11 00:00:00

  • Isolation and expression of a complementary DNA that confers multidrug resistance.

    abstract::The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/323728a0

    authors: Gros P,Ben Neriah YB,Croop JM,Housman DE

    更新日期:1986-10-23 00:00:00

  • Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

    abstract::Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known as TP53) influences a range of cellular metabolic processes, including glycolysis, oxidative phosphorylation, glutamino...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11743

    authors: Maddocks OD,Berkers CR,Mason SM,Zheng L,Blyth K,Gottlieb E,Vousden KH

    更新日期:2013-01-24 00:00:00

  • Artificial light at night as a new threat to pollination.

    abstract::Pollinators are declining worldwide and this has raised concerns for a parallel decline in the essential pollination service they provide to both crops and wild plants. Anthropogenic drivers linked to this decline include habitat changes, intensive agriculture, pesticides, invasive alien species, spread of pathogens a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature23288

    authors: Knop E,Zoller L,Ryser R,Gerpe C,Hörler M,Fontaine C

    更新日期:2017-08-10 00:00:00

  • Accessory cell-dependent selection of specific T-cell functions.

    abstract::Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/304442a0

    authors: Ramila G,Erb P

    更新日期:1983-08-04 00:00:00

  • Evolution of a central neural circuit underlies Drosophila mate preferences.

    abstract::Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0322-9

    authors: Seeholzer LF,Seppo M,Stern DL,Ruta V

    更新日期:2018-07-01 00:00:00

  • The open pore conformation of potassium channels.

    abstract::Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur. Pore-lining '...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/417523a

    authors: Jiang Y,Lee A,Chen J,Cadene M,Chait BT,MacKinnon R

    更新日期:2002-05-30 00:00:00

  • 'Mining' Bitcoin takes more energy than mining gold.

    abstract:: ...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/d41586-018-07283-3

    authors:

    更新日期:2018-11-01 00:00:00

  • Meiotic chromosome structures constrain and respond to designation of crossover sites.

    abstract::Crossover recombination events between homologous chromosomes are required to form chiasmata, temporary connections between homologues that ensure their proper segregation at meiosis I. Despite this requirement for crossovers and an excess of the double-strand DNA breaks that are the initiating events for meiotic reco...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12577

    authors: Libuda DE,Uzawa S,Meyer BJ,Villeneuve AM

    更新日期:2013-10-31 00:00:00

  • Co-localization of corticotropin-releasing factor and vasopressin in median eminence neurosecretory vesicles.

    abstract::Vasopressin (VP) potentiates the effect of corticotropin-releasing factor (CRF) on the secretion of adrenocorticotropic hormone (ACTH) from anterior pituitary cells in vitro, and both CRF and VP have been found in portal blood. These data support the hypothesis that VP acts synergistically with CRF to cause the secret...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/317248a0

    authors: Whitnall MH,Mezey E,Gainer H

    更新日期:1985-09-19 00:00:00

  • Androgenetic haploid embryonic stem cells produce live transgenic mice.

    abstract::Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11435

    authors: Li W,Shuai L,Wan H,Dong M,Wang M,Sang L,Feng C,Luo GZ,Li T,Li X,Wang L,Zheng QY,Sheng C,Wu HJ,Liu Z,Liu L,Wang L,Wang XJ,Zhao XY,Zhou Q

    更新日期:2012-10-18 00:00:00

  • The reaction mechanism of the internal thioester in the human complement component C4.

    abstract::A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/379177a0

    authors: Dodds AW,Ren XD,Willis AC,Law SK

    更新日期:1996-01-11 00:00:00

  • Natural killer cells act as rheostats modulating antiviral T cells.

    abstract::Antiviral T cells are thought to regulate whether hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or severe disease, although the reasons for these different outcomes remain unclear. Recent genetic evidence, however, has indicated a correlatio...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10624

    authors: Waggoner SN,Cornberg M,Selin LK,Welsh RM

    更新日期:2011-11-20 00:00:00

  • A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus.

    abstract::Mice express a collection of superantigens, which bind to class II major histocompatibility proteins and interact with T cells bearing particular V beta chains as part of their alpha beta receptors. These superantigens have been suggested to be encoded by exogenous or endogenous mouse mammary tumour viruses. One such ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/350203a0

    authors: Choi Y,Kappler JW,Marrack P

    更新日期:1991-03-21 00:00:00

  • Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish.

    abstract::Complementary DNAs for two distinct anglerfish somatostatin peptides (termed I and II) have been cloned in bacterial plasmids and sequenced. The nucleotide sequence for somatostatin I encodes a large percursor peptide (molecular weight 13,300) in which the somatostatin hormones is at the carboxyl terminus. The predict...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/288137a0

    authors: Hobart P,Crawford R,Shen L,Pictet R,Rutter WJ

    更新日期:1980-11-13 00:00:00

  • Functional screening identifies miRNAs inducing cardiac regeneration.

    abstract::In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11739

    authors: Eulalio A,Mano M,Dal Ferro M,Zentilin L,Sinagra G,Zacchigna S,Giacca M

    更新日期:2012-12-20 00:00:00