Columns for visual features of objects in monkey inferotemporal cortex.

abstract：:Type Ia supernovae have been used empirically as 'standard candles' to demonstrate the acceleration of the expansion of the Universe even though fundamental details, such as the nature of their progenitor systems and how the stars explode, remain a mystery. There is consensus that a white dwarf star explodes after acc...

journal_title：Nature

authors： Nugent PE,Sullivan M,Cenko SB,Thomas RC,Kasen D,Howell DA,Bersier D,Bloom JS,Kulkarni SR,Kandrashoff MT,Filippenko AV,Silverman JM,Marcy GW,Howard AW,Isaacson HT,Maguire K,Suzuki N,Tarlton JE,Pan YC,Bildsten L,Ful

更新日期：2011-12-14 00:00:00

abstract：:There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularly controversial. Although there are some well-characterized examples, most (>95%) show little evidence of evolutionary conservation and...

journal_title：Nature

authors： Guttman M,Amit I,Garber M,French C,Lin MF,Feldser D,Huarte M,Zuk O,Carey BW,Cassady JP,Cabili MN,Jaenisch R,Mikkelsen TS,Jacks T,Hacohen N,Bernstein BE,Kellis M,Regev A,Rinn JL,Lander ES

更新日期：2009-03-12 00:00:00

abstract：:Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

journal_title：Nature

authors： Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

更新日期：2000-08-17 00:00:00

abstract：:The enzyme isopenicillin N synthetase (IPS) catalyses the oxidative condensation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (LLD-ACV) to isopenicillin N, which is a central reaction in the pathway to clinically important penicillins and cephalosporins. Here we report the cloning, characterization and expressi...

journal_title：Nature

authors： Samson SM,Belagaje R,Blankenship DT,Chapman JL,Perry D,Skatrud PL,VanFrank RM,Abraham EP,Baldwin JE,Queener SW

更新日期：1985-11-14 00:00:00

abstract：:Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If such minority populations are associated with tumour progression in human patients, specific targeting of tumour-initiating cells...

journal_title：Nature

authors： Schatton T,Murphy GF,Frank NY,Yamaura K,Waaga-Gasser AM,Gasser M,Zhan Q,Jordan S,Duncan LM,Weishaupt C,Fuhlbrigge RC,Kupper TS,Sayegh MH,Frank MH

更新日期：2008-01-17 00:00:00

abstract：:Excitatory amino acids induce both acute membrane depolarization and latent cellular toxicity, which often leads to apoptosis in many neurological disorders. Recent studies indicate that glutamate toxicity may involve the c-Jun amino-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases. One member of...

journal_title：Nature

authors： Yang DD,Kuan CY,Whitmarsh AJ,Rincón M,Zheng TS,Davis RJ,Rakic P,Flavell RA

更新日期：1997-10-23 00:00:00

abstract：:Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes ...

journal_title：Nature

authors： Foreman BZ,Heller PL,Clementz MT

更新日期：2012-11-01 00:00:00

abstract：:During intracellular Ca2+ signalling mitochondria accumulate significant amounts of Ca2+ from the cytosol. Mitochondrial Ca2+ uptake controls the rate of energy production, shapes the amplitude and spatio-temporal patterns of intracellular Ca2+ signals, and is instrumental to cell death. This Ca2+ uptake is undertaken...

journal_title：Nature

authors： Kirichok Y,Krapivinsky G,Clapham DE

更新日期：2004-01-22 00:00:00

abstract：:Paired-associate learning is often used to examine episodic memory in humans. Animal models include the recall of food-cache locations by scrub jays and sequential memory. Here we report a model in which rats encode, during successive sample trials, two paired associates (flavours of food and their spatial locations) ...

journal_title：Nature

authors： Day M,Langston R,Morris RG

更新日期：2003-07-10 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, the process of conjugation of haploid cells of genotype MATa and MAT alpha to form MATa/alpha diploids is triggered by pheromones produced by each mating type. These pheromones stimulate a cellular response by interaction with receptors linked to a heterotrimeric G protei...

journal_title：Nature

authors： Simon MN,De Virgilio C,Souza B,Pringle JR,Abo A,Reed SI

更新日期：1995-08-24 00:00:00

abstract：:An observer moving forwards through the environment experiences a radial pattern of image motion on each retina. Such patterns of optic flow are a potential source of information about the observer's rate of progress, direction of heading and time to reach objects that lie ahead. As the viewing distance changes there ...

journal_title：Nature

authors： Busettini C,Masson GS,Miles FA

更新日期：1997-12-04 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we rep...

journal_title：Nature

authors： Sevigny J,Chiao P,Bussière T,Weinreb PH,Williams L,Maier M,Dunstan R,Salloway S,Chen T,Ling Y,O'Gorman J,Qian F,Arastu M,Li M,Chollate S,Brennan MS,Quintero-Monzon O,Scannevin RH,Arnold HM,Engber T,Rhodes K,Ferr

更新日期：2016-09-01 00:00:00

abstract：:Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...

journal_title：Nature

authors： Beck M,Lucić V,Förster F,Baumeister W,Medalia O

更新日期：2007-10-04 00:00:00

abstract：:Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...

journal_title：Nature

authors： Gardner AS,Moholdt G,Wouters B,Wolken GJ,Burgess DO,Sharp MJ,Cogley JG,Braun C,Labine C

更新日期：2011-05-19 00:00:00

abstract：:Highly collimated parsec-scale jets, which are generally linked to the presence of an accretion disk, are commonly observed in low-mass young stellar objects. In the past two decades, a few of these jets have been directly (or indirectly) observed from higher-mass (larger than eight solar masses) young stellar objects...

journal_title：Nature

authors： McLeod AF,Reiter M,Kuiper R,Klaassen PD,Evans CJ

更新日期：2018-02-15 00:00:00

abstract：:The 18-base-pair sequence element AGGTCGACCAGTACTCCG (the Sal box) signals termination of mouse ribosomal gene transcription. This sequence is recognized by a sequence-specific DNA-binding protein, TTF I, which mediates the termination of transcription by RNA polymerase I (pol I). Subsequently, the ends of the primary...

journal_title：Nature

authors： Kuhn A,Bartsch I,Grummt I

更新日期：1990-04-05 00:00:00

abstract：:The appendage primordia of Drosophila are subdivided into compartments by the localized expression of transcription factors. Interaction between cells in adjacent compartments establishes organizing centres responsible for generating spatial pattern and promoting cell proliferation in the developing appendages. Locali...

journal_title：Nature

authors： Diaz-Benjumea FJ,Cohen B,Cohen SM

更新日期：1994-11-10 00:00:00

abstract：:Many-body systems in nature exhibit complexity and self-organization arising from seemingly simple laws. For example, the long-range Coulomb interaction between electrical charges has a simple form, yet is responsible for a plethora of bound states in matter, ranging from the hydrogen atom to complex biochemical struc...

journal_title：Nature

authors： Kaindl RA,Carnahan MA,Hägele D,Lövenich R,Chemla DS

更新日期：2003-06-12 00:00:00

abstract：:Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur. Pore-lining '...

journal_title：Nature

authors： Jiang Y,Lee A,Chen J,Cadene M,Chait BT,MacKinnon R

更新日期：2002-05-30 00:00:00

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Acquired drug resistance is a major problem in the treatment of cancer. Of the more than 500,000 annual deaths from cancer in the United States, many follow the development of resistance to chemotherapy. The emergence of resistance depends in part on the genetic instability, heterogeneity and high mutational rate of t...

journal_title：Nature

authors： Boehm T,Folkman J,Browder T,O'Reilly MS

更新日期：1997-11-27 00:00:00

abstract：:The remarkable compositional diversity of volatile ices within comets can plausibly be attributed to several factors, including differences in the chemical, thermal and radiation environments in comet-forming regions, chemical evolution during their long storage in reservoirs far from the Sun, and thermal processing b...

journal_title：Nature

authors： Dello Russo N,Vervack RJ,Weaver HA,Biver N,Bockelée-Morvan D,Crovisier J,Lisse CM

更新日期：2007-07-12 00:00:00

abstract：:The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC...

journal_title：Nature

authors： Houde M,Bertholet S,Gagnon E,Brunet S,Goyette G,Laplante A,Princiotta MF,Thibault P,Sacks D,Desjardins M

更新日期：2003-09-25 00:00:00

abstract：:Troponin is essential in Ca(2+) regulation of skeletal and cardiac muscle contraction. It consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on the actin filament. Here we present crystal structures of the core domains (relative molecular mass of 46,000 and 52,000) of human cardia...

journal_title：Nature

authors： Takeda S,Yamashita A,Maeda K,Maéda Y

更新日期：2003-07-03 00:00:00

abstract：:Polymer electrolyte membrane fuel cells (PEMFCs) running on hydrogen are attractive alternative power supplies for a range of applications, with in situ release of the required hydrogen from a stable liquid offering one way of ensuring its safe storage and transportation before use. The use of methanol is particularly...

journal_title：Nature

authors： Lin L,Zhou W,Gao R,Yao S,Zhang X,Xu W,Zheng S,Jiang Z,Yu Q,Li YW,Shi C,Wen XD,Ma D

更新日期：2017-04-06 00:00:00

abstract：:Protein folding and binding are analogous processes, in which the protein 'searches' for favourable intramolecular or intermolecular interactions on a funnelled energy landscape. Many eukaryotic proteins are disordered under physiological conditions, and fold into ordered structures only on binding to their cellular t...

journal_title：Nature

authors： Sugase K,Dyson HJ,Wright PE

更新日期：2007-06-21 00:00:00

abstract：:Environmental change is rapidly accelerating, and many species will need to adapt to survive1. Ensuring that protected areas cover populations across a broad range of environmental conditions could safeguard the processes that lead to such adaptations1-3. However, international conservation policies have largely negle...

journal_title：Nature

authors： Hanson JO,Rhodes JR,Butchart SHM,Buchanan GM,Rondinini C,Ficetola GF,Fuller RA

更新日期：2020-04-01 00:00:00

abstract：:Non-ribosomal peptide synthetase (NRPS) mega-enzyme complexes are modular assembly lines that are involved in the biosynthesis of numerous peptide metabolites independently of the ribosome. The multiple interactions between catalytic domains within the NRPS machinery are further complemented by additional interactions...

journal_title：Nature

authors： Haslinger K,Peschke M,Brieke C,Maximowitsch E,Cryle MJ

更新日期：2015-05-07 00:00:00

abstract：:Convection is a fundamental physical process in the fluid cores of planets. It is the primary transport mechanism for heat and chemical species and the primary energy source for planetary magnetic fields. Key properties of convection-such as the characteristic flow velocity and length scale-are poorly quantified in pl...

journal_title：Nature

authors： Guervilly C,Cardin P,Schaeffer N

更新日期：2019-06-01 00:00:00

abstract：:The establishment of embryonic polarity is a crucial step in pattern formation and morphogenesis. In the fruitfly Drosophila melanogaster, embryonic polarity depends primarily on genes expressed in the female during oogenesis. Mutations in these 'maternal effect' genes can lead to major disruptions in normal pattern f...

journal_title：Nature

authors： Steward R,McNally FJ,Schedl P

更新日期：1984-09-20 00:00:00