A parsec-scale optical jet from a massive young star in the Large Magellanic Cloud.

abstract：:Although lunar crystalline rocks are essentially devoid of nitrogen, the same is not true of the lunar regolith. The nitrogen contents of individual regolith samples (which can be as high as 0.012% by mass) correlate strongly with abundances of noble gases known to be implanted in the lunar surface by solar radiation,...

journal_title：Nature

authors： Kim JS,Kim Y,Marti K,Kerridge JF

更新日期：1995-06-01 00:00:00

abstract：:T lymphocytes are predisposed to recognition of foreign protein fragments bound to cell-surface molecules encoded by the major histocompatibility complex (MHC). There is now compelling evidence that this specificity is a consequence of a selection process operating on developing T lymphocytes in the thymus. As a resul...

journal_title：Nature

authors： Kaye J,Hsu ML,Sauron ME,Jameson SC,Gascoigne NR,Hedrick SM

更新日期：1989-10-26 00:00:00

abstract：:Genomic imprinting is an allele-specific gene expression system that is important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation. Although it is well known that the de novo DNA methyltransferases Dnmt3a and Dnmt3b are responsible for the establishme...

journal_title：Nature

authors： Yamaguchi S,Shen L,Liu Y,Sendler D,Zhang Y

更新日期：2013-12-19 00:00:00

abstract：:Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generati...

journal_title：Nature

authors： Abyzov A,Mariani J,Palejev D,Zhang Y,Haney MS,Tomasini L,Ferrandino AF,Rosenberg Belmaker LA,Szekely A,Wilson M,Kocabas A,Calixto NE,Grigorenko EL,Huttner A,Chawarska K,Weissman S,Urban AE,Gerstein M,Vaccarino FM

更新日期：2012-12-20 00:00:00

abstract：:The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...

journal_title：Nature

authors： Ooi YM,Ooi BS

更新日期：1982-07-22 00:00:00

abstract：:Since the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than understanding how insulin works at the cellular level. Insulin binds to the alpha subunit of the insulin receptor which activates the tyrosine kinase in the beta subunit, but the molecular events li...

journal_title：Nature

authors： Sun XJ,Rothenberg P,Kahn CR,Backer JM,Araki E,Wilden PA,Cahill DA,Goldstein BJ,White MF

更新日期：1991-07-04 00:00:00

abstract：:Ice volume (and hence sea level) and deep-sea temperature are key measures of global climate change. Sea level has been documented using several independent methods over the past 0.5 million years (Myr). Older periods, however, lack such independent validation; all existing records are related to deep-sea oxygen isoto...

journal_title：Nature

authors： Rohling EJ,Foster GL,Grant KM,Marino G,Roberts AP,Tamisiea ME,Williams F

更新日期：2014-04-24 00:00:00

abstract：:Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-catenin in vivo that incr...

journal_title：Nature

authors： Zhang Z,Hartmann H,Do VM,Abramowski D,Sturchler-Pierrat C,Staufenbiel M,Sommer B,van de Wetering M,Clevers H,Saftig P,De Strooper B,He X,Yankner BA

更新日期：1998-10-15 00:00:00

abstract：:The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...

journal_title：Nature

authors： Lam YA,Lawson TG,Velayutham M,Zweier JL,Pickart CM

更新日期：2002-04-18 00:00:00

abstract：:Speciation in many animal taxa is catalysed by the evolutionary diversification of mating signals. According to classical theories of speciation, mating signals diversify, in part, as an incidental byproduct of adaptation by natural selection to divergent ecologies, although empirical evidence in support of this hypot...

journal_title：Nature

authors： Podos J

更新日期：2001-01-11 00:00:00

abstract：:Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

journal_title：Nature

authors： Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

更新日期：2001-07-05 00:00:00

abstract：:Accurate measurement of the lifetime of the neutron (which is unstable to beta decay) is important for understanding the weak nuclear force and the creation of matter during the Big Bang. Previous measurements of the neutron lifetime have mainly been limited by certain systematic errors; however, these could in princi...

journal_title：Nature

authors： Huffman PR,Brome CR,Butterworth JS,Coakley KJ,Dewey MS,Dzhosyuk SN,Golub R,Greene GL,Habicht K,Lamoreaux SK,Mattoni CE,McKinsey DN,Wietfeldt FE,Doyle JM

更新日期：2000-01-06 00:00:00

abstract：:'Long' gamma-ray bursts (GRBs) are commonly accepted to originate in the explosion of particularly massive stars, which give rise to highly relativistic jets. Inhomogeneities in the expanding flow result in internal shock waves that are believed to produce the gamma-rays we see. As the jet travels further outward into...

journal_title：Nature

authors： Tagliaferri G,Goad M,Chincarini G,Moretti A,Campana S,Burrows DN,Perri M,Barthelmy SD,Gehrels N,Krimm H,Sakamoto T,Kumar P,Mészáros PI,Kobayashi S,Zhang B,Angelini L,Banat P,Beardmore AP,Capalbi M,Covino S,Cusuman

更新日期：2005-08-18 00:00:00

abstract：:On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into three distinct domains. Only the central domain (approximately 80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds ...

journal_title：Nature

authors： Allan J,Hartman PG,Crane-Robinson C,Aviles FX

更新日期：1980-12-25 00:00:00

abstract：:Crustal faults have long been identified as sites where localized sliding motion occurs during earthquakes, which allows for the relative motion between adjacent crustal blocks. Although there is a growing awareness that we must understand the evolution of fault systems on many timescales to relate present-day crustal...

journal_title：Nature

authors： Vidale JE,Li YG

更新日期：2003-01-30 00:00:00

abstract：:The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small cell lung cancers harbouring activating mutations in the EGFR kinase, but resistance arises rapidly, most frequently owing to the secondary T790M mutation withi...

journal_title：Nature

authors： Jia Y,Yun CH,Park E,Ercan D,Manuia M,Juarez J,Xu C,Rhee K,Chen T,Zhang H,Palakurthi S,Jang J,Lelais G,DiDonato M,Bursulaya B,Michellys PY,Epple R,Marsilje TH,McNeill M,Lu W,Harris J,Bender S,Wong KK,Jänne PA

更新日期：2016-06-02 00:00:00

abstract：:DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so far no base-resoluti...

journal_title：Nature

authors： Smith ZD,Chan MM,Mikkelsen TS,Gu H,Gnirke A,Regev A,Meissner A

更新日期：2012-03-28 00:00:00

abstract：:The balance between stem cell self-renewal and differentiation is controlled by intrinsic factors and niche signals. In the Drosophila melanogaster ovary, some intrinsic factors promote germline stem cell (GSC) self-renewal, whereas others stimulate differentiation. However, it remains poorly understood how the balanc...

journal_title：Nature

authors： Pan L,Wang S,Lu T,Weng C,Song X,Park JK,Sun J,Yang ZH,Yu J,Tang H,McKearin DM,Chamovitz DA,Ni J,Xie T

更新日期：2014-10-09 00:00:00

abstract：:Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...

journal_title：Nature

authors： Elwood PC,Gallacher JE,Phillips KM,Davies BE,Toothill C

更新日期：1984-07-12 00:00:00

abstract：:The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic fa...

journal_title：Nature

authors： Rose CR,Blum R,Pichler B,Lepier A,Kafitz KW,Konnerth A

更新日期：2003-11-06 00:00:00

abstract：:The interaction of lectins with carbohydrate receptors on the plasma membrane of eukaryotic cells results in a wide variety of biological effects. One effect which has been extensively studied is the stimulation of lymphocytes to blastogenesis and proliferation. High doses of concanavalin A (Con A) and phytohaemagglut...

journal_title：Nature

authors： Hilgert I,Horejsí V,Angelisová P,Kristofová H

更新日期：1980-03-20 00:00:00

abstract：:Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure. Recently, the mouse ob gene, and subsequently its human and rat homologues, have been cloned. The ob gene product, leptin, is expressed exclusively in adipose tissue, and appears to be a signalling facto...

journal_title：Nature

authors： Saladin R,De Vos P,Guerre-Millo M,Leturque A,Girard J,Staels B,Auwerx J

更新日期：1995-10-12 00:00:00

abstract：:Magnetic fields play a part in almost all stages of stellar evolution. Most low-mass stars, including the Sun, show surface fields that are generated by dynamo processes in their convective envelopes. Intermediate-mass stars do not have deep convective envelopes, although 10 per cent exhibit strong surface fields that...

journal_title：Nature

authors： Stello D,Cantiello M,Fuller J,Huber D,García RA,Bedding TR,Bildsten L,Aguirre VS

更新日期：2016-01-21 00:00:00

abstract：:Scientific theories of how subduction and plate tectonics began on Earth--and what the tectonic structure of Earth was before this--remain enigmatic and contentious. Understanding viable scenarios for the onset of subduction and plate tectonics is hampered by the fact that subduction initiation processes must have bee...

journal_title：Nature

authors： Gerya TV,Stern RJ,Baes M,Sobolev SV,Whattam SA

更新日期：2015-11-12 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeats (CRISPR)-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA-DNA base-pairing to target foreign DNA in bacteria. Cas9-guide RNA complexes are also effective genome engineering agents in animals and plants. Here we use single-molecule and bulk...

journal_title：Nature

authors： Sternberg SH,Redding S,Jinek M,Greene EC,Doudna JA

更新日期：2014-03-06 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：:Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...

journal_title：Nature

authors： Bersuker K,Hendricks JM,Li Z,Magtanong L,Ford B,Tang PH,Roberts MA,Tong B,Maimone TJ,Zoncu R,Bassik MC,Nomura DK,Dixon SJ,Olzmann JA

更新日期：2019-11-01 00:00:00

abstract：:In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome1,2. However, the contribution of spatial genome organization to the regulation of developmental programs is unclear3. Here we generate high-resolution maps of genomic interactions wit...

journal_title：Nature

authors： Borsos M,Perricone SM,Schauer T,Pontabry J,de Luca KL,de Vries SS,Ruiz-Morales ER,Torres-Padilla ME,Kind J

更新日期：2019-05-01 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00

abstract：:Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...

journal_title：Nature

authors： Toda S,Stein RS,Sagiya T

更新日期：2002-09-05 00:00:00