An unexpectedly rapid decline in the X-ray afterglow emission of long gamma-ray bursts.

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease. In particular, hMSH2 and hMLH1 homologues of the bacterial DNA mismatch repair genes mutS and mutL, respectively, were sh...

journal_title：Nature

authors： Nicolaides NC,Papadopoulos N,Liu B,Wei YF,Carter KC,Ruben SM,Rosen CA,Haseltine WA,Fleischmann RD,Fraser CM

更新日期：1994-09-01 00:00:00

abstract：:Bird songs frequently contain trilling sounds that demand extremely fast vocalization control. Here we show that doves control their syrinx, a vocal organ that is unique to birds, by using superfast muscles. These muscles, which are similar to those that operate highly specialist acoustic organs such as the rattle of ...

journal_title：Nature

authors： Elemans CP,Spierts IL,Müller UK,Van Leeuwen JL,Goller F

更新日期：2004-09-09 00:00:00

abstract：:Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term g...

journal_title：Nature

authors： Zalzman M,Falco G,Sharova LV,Nishiyama A,Thomas M,Lee SL,Stagg CA,Hoang HG,Yang HT,Indig FE,Wersto RP,Ko MS

更新日期：2010-04-08 00:00:00

abstract：:Emerging infectious diseases present a formidable challenge to the conservation of native species in the twenty-first century. Diseases caused by introduced pathogens have had large impacts on species abundances, including the American chestnut, Hawaiian bird species and many amphibians. Changes in host population siz...

journal_title：Nature

authors： LaDeau SL,Kilpatrick AM,Marra PP

更新日期：2007-06-07 00:00:00

abstract：:The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...

journal_title：Nature

authors： Higgins AM,Jones RA

更新日期：2000-03-30 00:00:00

abstract：:Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6. ...

journal_title：Nature

authors： Minhas PS,Latif-Hernandez A,McReynolds MR,Durairaj AS,Wang Q,Rubin A,Joshi AU,He JQ,Gauba E,Liu L,Wang C,Linde M,Sugiura Y,Moon PK,Majeti R,Suematsu M,Mochly-Rosen D,Weissman IL,Longo FM,Rabinowitz JD,Andreasson K

更新日期：2021-01-20 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complemen...

journal_title：Nature

authors： Janssen BJ,Christodoulidou A,McCarthy A,Lambris JD,Gros P

更新日期：2006-11-09 00:00:00

abstract：:The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...

journal_title：Nature

authors： Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

更新日期：2002-03-28 00:00:00

abstract：:CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1-6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify off-targets in vivo has not been described to date, which means it is cu...

journal_title：Nature

authors： Akcakaya P,Bobbin ML,Guo JA,Malagon-Lopez J,Clement K,Garcia SP,Fellows MD,Porritt MJ,Firth MA,Carreras A,Baccega T,Seeliger F,Bjursell M,Tsai SQ,Nguyen NT,Nitsch R,Mayr LM,Pinello L,Bohlooly-Y M,Aryee MJ,Maresca

更新日期：2018-09-01 00:00:00

abstract：:The opening and closing of voltage-activated Na+, Ca2+ and K+ (Kv) channels underlies electrical and chemical signalling throughout biology, yet the structural basis of voltage sensing is unknown. Hanatoxin is a tarantula toxin that inhibits Kv channels by binding to voltage-sensor paddles, crucial helix-turn-helix mo...

journal_title：Nature

authors： Phillips LR,Milescu M,Li-Smerin Y,Mindell JA,Kim JI,Swartz KJ

更新日期：2005-08-11 00:00:00

abstract：:Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating, better understanding of the mechanisms underlying obesity-associated cancer...

journal_title：Nature

authors： Yoshimoto S,Loo TM,Atarashi K,Kanda H,Sato S,Oyadomari S,Iwakura Y,Oshima K,Morita H,Hattori M,Honda K,Ishikawa Y,Hara E,Ohtani N

更新日期：2013-07-04 00:00:00

abstract：:The Late Devonian genus Ichthyostega was for many decades the earliest known tetrapod, and the sole representative of a transitional form between a fish and a land vertebrate. However, despite being known since 1932 (ref. 1) from a large collection of specimens, its morphology remained enigmatic and not what was expec...

journal_title：Nature

authors： Clack JA,Ahlberg PE,Finney SM,Dominguez Alonso P,Robinson J,Ketcham RA

更新日期：2003-09-04 00:00:00

abstract：:The dry valleys of southern Victoria Land in Antarctica contain several closed basins in which perennially ice-covered lakes are found. One of the most unusual features of these lakes is the occurrence of high O2 concentrations in the water column; values ranging from slightly more than saturation to more than four t...

journal_title：Nature

authors： Wharton RA Jr,McKay CP,Mancinelli RL,Simmons GM Jr

更新日期：1987-01-22 00:00:00

abstract：:Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium. Afterglow polarization directly probes the magnetic properties of the jet when measured mi...

journal_title：Nature

authors： Wiersema K,Covino S,Toma K,van der Horst AJ,Varela K,Min M,Greiner J,Starling RL,Tanvir NR,Wijers RA,Campana S,Curran PA,Fan Y,Fynbo JP,Gorosabel J,Gomboc A,Götz D,Hjorth J,Jin ZP,Kobayashi S,Kouveliotou C,Munde

更新日期：2014-05-08 00:00:00

abstract：:Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. Howeve...

journal_title：Nature

authors： Furusawa Y,Obata Y,Fukuda S,Endo TA,Nakato G,Takahashi D,Nakanishi Y,Uetake C,Kato K,Kato T,Takahashi M,Fukuda NN,Murakami S,Miyauchi E,Hino S,Atarashi K,Onawa S,Fujimura Y,Lockett T,Clarke JM,Topping DL,Tomita

更新日期：2013-12-19 00:00:00

abstract：:Therizinosauroids are an enigmatic group of dinosaurs known mostly from the Cretaceous period of Asia, whose derived members are characterized by elongate necks, laterally expanded pelves, small, leaf-shaped teeth, edentulous rostra and mandibular symphyses that probably bore keratinized beaks. Although more than a do...

journal_title：Nature

authors： Kirkland JI,Zanno LE,Sampson SD,Clark JM,DeBlieux DD

更新日期：2005-05-05 00:00:00

abstract：:Protecting the world's freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts f...

journal_title：Nature

authors： Vörösmarty CJ,McIntyre PB,Gessner MO,Dudgeon D,Prusevich A,Green P,Glidden S,Bunn SE,Sullivan CA,Liermann CR,Davies PM

更新日期：2010-09-30 00:00:00

abstract：:The extent to which an organism is selected to invest in defences against pathogens and parasites depends on the advantages that ensue should infection occur, but also on the costs of maintaining defences in the absence of infection. The presence of heritable variation in resistance suggests that costs exist, but we k...

journal_title：Nature

authors： Kraaijeveld AR,Godfray HC

更新日期：1997-09-18 00:00:00

abstract：:Carbonates on large Solar System bodies like Earth and Mars (the latter represented by the meteorite ALH84001) form through the weathering of silicates in a watery (CO3)2- solution. The presence of carbonates in interplanetary dust particles and asteroids (again, represented by meteorites) is not completely understood...

journal_title：Nature

authors： Kemper F,Jäger C,Waters LB,Henning T,Molster FJ,Barlow MJ,Lim T,de Koter A

更新日期：2002-01-17 00:00:00

abstract：:Braunwald, a professor at Harvard Medical School, responds to a paper by Walter W. Stewart and Ned Feder ("The integrity of the scientific literature," Nature 1987 Jan 15; 325(6101): 207-214) concerning their findings of errors, discrepancies, and other lapses in publications coauthored by John Darsee, a biomedical re...

journal_title：Nature

authors： Braunwald E

更新日期：1987-01-15 00:00:00

abstract：:Halobacterium halobium is an obligately halophilic archaebacterium of interest to molecular biologists for many reasons, one of which is the unexplained high frequency (10(-4)-10(-2) mutants per cell plated) at which it yields readily identifiable and unstable mutants. We showed previously that the genome of H. halobi...

journal_title：Nature

authors： Sapienza C,Rose MR,Doolittle WF

更新日期：1982-09-09 00:00:00

abstract：:Courtship is an innate sexually dimorphic behaviour that can be observed in naive animals without previous learning or experience, suggesting that the neural circuits that mediate this behaviour are developmentally programmed. In Drosophila, courtship involves a complex yet stereotyped array of dimorphic behaviours th...

journal_title：Nature

authors： Datta SR,Vasconcelos ML,Ruta V,Luo S,Wong A,Demir E,Flores J,Balonze K,Dickson BJ,Axel R

更新日期：2008-03-27 00:00:00

abstract：:So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of familial cases, and predisposing mutations in CDK4 have been reported in a very small number of melanoma kindreds. Here we report the who...

journal_title：Nature

authors： Yokoyama S,Woods SL,Boyle GM,Aoude LG,MacGregor S,Zismann V,Gartside M,Cust AE,Haq R,Harland M,Taylor JC,Duffy DL,Holohan K,Dutton-Regester K,Palmer JM,Bonazzi V,Stark MS,Symmons J,Law MH,Schmidt C,Lanagan C,O'C

更新日期：2011-11-13 00:00:00

abstract：:The initiation of plate tectonics on Earth is a critical event in our planet's history. The time lag between the first proto-subduction (about 4 billion years ago) and global tectonics (approximately 3 billion years ago) suggests that plates and plate boundaries became widespread over a period of 1 billion years. The ...

journal_title：Nature

authors： Bercovici D,Ricard Y

更新日期：2014-04-24 00:00:00

abstract：:Alkaloids, secondary metabolites that contain basic nitrogen atoms, are some of the most well-known biologically active natural products in chemistry and medicine. Although efficient laboratory synthesis of alkaloids would enable the study and optimization of their biological properties, their preparation is often com...

journal_title：Nature

authors： Parr BT,Economou C,Herzon SB

更新日期：2015-09-24 00:00:00

abstract：:Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central goal of synthetic biology is to create new life forms and functions, and the most general route to this goal is th...

journal_title：Nature

authors： Zhang Y,Ptacin JL,Fischer EC,Aerni HR,Caffaro CE,San Jose K,Feldman AW,Turner CR,Romesberg FE

更新日期：2017-11-29 00:00:00

abstract：:Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The molecular details of oligomerization and the mechanism of the mechanochemical coupling are currently unknown. Here we present the crystal structure of h...

journal_title：Nature

authors： Faelber K,Posor Y,Gao S,Held M,Roske Y,Schulze D,Haucke V,Noé F,Daumke O

更新日期：2011-09-18 00:00:00

abstract：:Change history: In this Letter, the bottom blot in Fig. 2g (for 'IB: Myc') was missing. This has been corrected online. ...

journal_title：Nature

authors： Su T,Izawa T,Thoms M,Yamashita Y,Cheng J,Berninghausen O,Hartl FU,Inada T,Neupert W,Beckmann R

更新日期：2019-07-01 00:00:00

abstract：:The complete knowledge of a quantum state allows the prediction of the probability of all possible measurement outcomes, a crucial step in quantum mechanics. It can be provided by tomographic methods which have been applied to atomic, molecular, spin and photonic states. For optical or microwave photons, standard tomo...

journal_title：Nature

authors： Jullien T,Roulleau P,Roche B,Cavanna A,Jin Y,Glattli DC

更新日期：2014-10-30 00:00:00