Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form.

abstract：:This corrects the article DOI: 10.1038/nature24295. ...

journal_title：Nature

authors： Waldron A,Miller DC,Redding D,Mooers A,Kuhn TS,Nibbelink N,Roberts JT,Tobias JA,Gittleman JL

更新日期：2018-01-25 00:00:00

abstract：:Measurement of the free calcium concentration within a photo-receptor outer segment has been considered an important aim since the proposal by Hagins and Yoshikami that the primary event in phototransduction is a release of Ca (2+) inside the cell. More recent evidence has cast doubt on the calcium hypothesis, and the...

journal_title：Nature

authors： McNaughton PA,Cervetto L,Nunn BJ

更新日期：1986-07-17 00:00:00

abstract：:Using a recently developed formalism called topological quantum chemistry, we perform a high-throughput search of 'high-quality' materials (for which the atomic positions and structure have been measured very accurately) in the Inorganic Crystal Structure Database in order to identify new topological phases. We develo...

journal_title：Nature

authors： Vergniory MG,Elcoro L,Felser C,Regnault N,Bernevig BA,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smok...

journal_title：Nature

authors： Fowler JS,Volkow ND,Wang GJ,Pappas N,Logan J,MacGregor R,Alexoff D,Shea C,Schlyer D,Wolf AP,Warner D,Zezulkova I,Cilento R

更新日期：1996-02-22 00:00:00

abstract：:The cartilage and skin of animals, which are made up of more than fifty per cent water, are rather stiff (having elastic moduli of up to 100 megapascals) as well as tough and hard to break (with fracture energies of up to 9,000 joules per square metre). Such features make these biological materials mechanically superi...

journal_title：Nature

authors： Rauner N,Meuris M,Zoric M,Tiller JC

更新日期：2017-03-16 00:00:00

abstract：:The spacing of opening-mode fractures in layered materials--such as certain sedimentary rocks and laminated engineering materials--is often proportional to the thickness of the fractured layer. Experimental studies of this phenomenon show that the spacing initially decreases as extensional strain increases in the dire...

journal_title：Nature

authors： Bai T,Pollard DD,Gao H

更新日期：2000-02-17 00:00:00

abstract：:When chemical reactions whose rate increases with the concentration of a product species are carried out in imperfectly mixed systems, a variety of complex behaviours can occur. These phenomena, which have relevance for biological processes as well, include chaotic and stochastic behaviour and selection of one final s...

journal_title：Nature

authors： Epstein IR

更新日期：1995-03-23 00:00:00

abstract：:D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...

journal_title：Nature

authors： Lukas J,Parry D,Aagaard L,Mann DJ,Bartkova J,Strauss M,Peters G,Bartek J

更新日期：1995-06-08 00:00:00

abstract：:The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions. The gene for protein S has been cloned and the DNA se...

journal_title：Nature

authors： Wistow G,Summers L,Blundell T

更新日期：1985-06-27 00:00:00

abstract：:Many cellular functions involve multi-domain proteins, which are composed of structurally independent modules connected by flexible linkers. Although it is often well understood how a given domain recognizes a cognate oligonucleotide or peptide motif, the dynamic interaction of multiple domains in the recognition of t...

journal_title：Nature

authors： Mackereth CD,Madl T,Bonnal S,Simon B,Zanier K,Gasch A,Rybin V,Valcárcel J,Sattler M

更新日期：2011-07-13 00:00:00

abstract：:Groundwater is a primary source of fresh water in many parts of the world. Some regions are becoming overly dependent on it, consuming groundwater faster than it is naturally replenished and causing water tables to decline unremittingly. Indirect evidence suggests that this is the case in northwest India, but there ha...

journal_title：Nature

authors： Rodell M,Velicogna I,Famiglietti JS

更新日期：2009-08-20 00:00:00

abstract：:Protoplanetary disks are known to possess a variety of substructures in the distribution of their millimetre-sized grains, predominantly seen as rings and gaps1, which are frequently interpreted as arising from the shepherding of large grains by either hidden, still-forming planets within the disk2 or (magneto-)hydrod...

journal_title：Nature

authors： Teague R,Bae J,Bergin EA

更新日期：2019-10-01 00:00:00

abstract：:Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local d...

journal_title：Nature

authors： Gambino F,Pagès S,Kehayas V,Baptista D,Tatti R,Carleton A,Holtmaat A

更新日期：2014-11-06 00:00:00

abstract：:Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...

journal_title：Nature

authors： de Godoy LM,Olsen JV,Cox J,Nielsen ML,Hubner NC,Fröhlich F,Walther TC,Mann M

更新日期：2008-10-30 00:00:00

abstract：:We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...

journal_title：Nature

authors： Simmons RM,Szent-Györgyi AG

更新日期：1980-08-07 00:00:00

abstract：:A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and...

journal_title：Nature

authors： Chumakov I,Rigault P,Guillou S,Ougen P,Billaut A,Guasconi G,Gervy P,LeGall I,Soularue P,Grinas L

更新日期：1992-10-01 00:00:00

abstract：:Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...

journal_title：Nature

authors： Gundem G,Van Loo P,Kremeyer B,Alexandrov LB,Tubio JMC,Papaemmanuil E,Brewer DS,Kallio HML,Högnäs G,Annala M,Kivinummi K,Goody V,Latimer C,O'Meara S,Dawson KJ,Isaacs W,Emmert-Buck MR,Nykter M,Foster C,Kote-Jarai Z,

更新日期：2015-04-16 00:00:00

abstract：:The current picture of galaxy evolution advocates co-evolution of galaxies and their nuclear massive black holes, through accretion and galactic merging. Pairs of quasars, each with a massive black hole at the centre of its galaxy, have separations of 6,000 to 300,000 light years (refs 2 and 3; 1 parsec = 3.26 light y...

journal_title：Nature

authors： Fabbiano G,Wang J,Elvis M,Risaliti G

更新日期：2011-08-31 00:00:00

abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...

journal_title：Nature

authors： Catalan G,Scott JF

更新日期：2007-08-23 00:00:00

abstract：:The brightness of type Ia supernovae, and their homogeneity as a class, makes them powerful tools in cosmology, yet little is known about the progenitor systems of these explosions. They are thought to arise when a white dwarf accretes matter from a companion star, is compressed and undergoes a thermonuclear explosion...

journal_title：Nature

authors： Ruiz-Lapuente P,Comeron F,Méndez J,Canal R,Smartt SJ,Filippenko AV,Kurucz RL,Chornock R,Foley RJ,Stanishev V,Ibata R

更新日期：2004-10-28 00:00:00

abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...

journal_title：Nature

authors： Perez-Ruiz E,Minute L,Otano I,Alvarez M,Ochoa MC,Belsue V,de Andrea C,Rodriguez-Ruiz ME,Perez-Gracia JL,Marquez-Rodas I,Llacer C,Alvarez M,de Luque V,Molina C,Teijeira A,Berraondo P,Melero I

更新日期：2019-05-01 00:00:00

abstract：:The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory1,2. Although the importance of regions such as the ventral tegmental area3,4 and locus coeruleus5 in broa...

journal_title：Nature

authors： Chen S,He L,Huang AJY,Boehringer R,Robert V,Wintzer ME,Polygalov D,Weitemier AZ,Tao Y,Gu M,Middleton SJ,Namiki K,Hama H,Therreau L,Chevaleyre V,Hioki H,Miyawaki A,Piskorowski RA,McHugh TJ

更新日期：2020-10-01 00:00:00

abstract：:P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y1-like receptors and P2Y12-like receptors. Their ligands are generally charged molecules w...

journal_title：Nature

authors： Zhang K,Zhang J,Gao ZG,Zhang D,Zhu L,Han GW,Moss SM,Paoletta S,Kiselev E,Lu W,Fenalti G,Zhang W,Müller CE,Yang H,Jiang H,Cherezov V,Katritch V,Jacobson KA,Stevens RC,Wu B,Zhao Q

更新日期：2014-05-01 00:00:00

abstract：:Promoters are DNA sequences that have an essential role in controlling gene expression. While recent whole cancer genome analyses have identified numerous hotspots of somatic point mutations within promoters, many have not yet been shown to perturb gene expression or drive cancer development. As such, positive selecti...

journal_title：Nature

authors： Perera D,Poulos RC,Shah A,Beck D,Pimanda JE,Wong JW

更新日期：2016-04-14 00:00:00

abstract：:Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the...

journal_title：Nature

authors： Broek D,Bartlett R,Crawford K,Nurse P

更新日期：1991-01-31 00:00:00

abstract：:Arbuscular mycorrhizal (AM) fungi (Glomeromycota) reproduce asexually, are multinucleate, and have high genetic variation within single cells. Pawlowska and Taylor find that genetic variation within AM fungal cells is not lost as a result of segregation, and they interpret this as evidence that the variation is presen...

journal_title：Nature

authors： Bever JD,Wang M

更新日期：2005-01-13 00:00:00

abstract：:Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for...

journal_title：Nature

authors： Donehower LA,Harvey M,Slagle BL,McArthur MJ,Montgomery CA Jr,Butel JS,Bradley A

更新日期：1992-03-19 00:00:00

abstract：:Retinoic acid is a vitamin A derivative with striking effects on development and cell differentiation. Several nuclear retinoic acid receptors (RARs), acting as ligand-inducible transcription factors, have been characterized and indirect evidence suggests that they have distinct roles. One of the most intriguing prope...

journal_title：Nature

authors： de Thé H,Chomienne C,Lanotte M,Degos L,Dejean A

更新日期：1990-10-11 00:00:00

abstract：:Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...

journal_title：Nature

authors： Wyart C,Del Bene F,Warp E,Scott EK,Trauner D,Baier H,Isacoff EY

更新日期：2009-09-17 00:00:00

abstract：:The induction of polyarthritis in rats by intradermal immunisation with homologous or heterologous type II collagen incomplete or incomplete Freund's adjuvant was reported recently by Trentham et al. We have now produced a similar disease in certain strains of mice. ...

journal_title：Nature

authors： Courtenay JS,Dallman MJ,Dayan AD,Martin A,Mosedale B

更新日期：1980-02-14 00:00:00