Abstract：
:Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.
journal_name
Naturejournal_title
Natureauthors
Donehower LA,Harvey M,Slagle BL,McArthur MJ,Montgomery CA Jr,Butel JS,Bradley Adoi
10.1038/356215a0keywords:
subject
Has Abstractpub_date
1992-03-19 00:00:00pages
215-21issue
6366eissn
0028-0836issn
1476-4687journal_volume
356pub_type
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