Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.

abstract：:It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure. AVP administered subcutaneously (s.c.), intraventricularly or intracerebrally can prolong extinction of acti...

journal_title：Nature

authors： Koob GF,Dantzer R,Rodriguez F,Bloom FE,Le Moal M

更新日期：1985-06-27 00:00:00

abstract：:Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function. In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosensitivity. These processes share a common mechanism that involves the release of ATP to excite afferent fibres via acti...

journal_title：Nature

authors： Gourine AV,Llaudet E,Dale N,Spyer KM

更新日期：2005-07-07 00:00:00

abstract：:Spontaneous symmetry breaking plays a key role in our understanding of nature. In relativistic quantum field theory, a broken continuous symmetry leads to the emergence of two types of fundamental excitation: massless Nambu-Goldstone modes and a massive 'Higgs' amplitude mode. An excitation of Higgs type is of crucial...

journal_title：Nature

authors： Endres M,Fukuhara T,Pekker D,Cheneau M,Schauss P,Gross C,Demler E,Kuhr S,Bloch I

更新日期：2012-07-25 00:00:00

abstract：:Pathogenesis in sickle cell disease depends on the polymerization of deoxyhaemoglobin S into long fibres followed by 'gel' formation. The 'gelation' renders the affected erythrocytes less deformable than normal so that they obstruct the microvasculature and the 'gelation' process has been one of the targets for the de...

journal_title：Nature

authors： Briehl RW

更新日期：1980-12-11 00:00:00

abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...

journal_title：Nature

authors： Mollicone D,Eva HD,Achard F

更新日期：2006-03-23 00:00:00

abstract：:Viruses are the most abundant biological organisms of the world's oceans. Viral infections are a substantial source of mortality in a range of organisms-including autotrophic and heterotrophic plankton-but their impact on the deep ocean and benthic biosphere is completely unknown. Here we report that viral production ...

journal_title：Nature

authors： Danovaro R,Dell'Anno A,Corinaldesi C,Magagnini M,Noble R,Tamburini C,Weinbauer M

更新日期：2008-08-28 00:00:00

abstract：:A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement tha...

journal_title：Nature

authors： Martin-Zanca D,Hughes SH,Barbacid M

更新日期：1986-02-27 00:00:00

abstract：:High-harmonic generation is a well-known method of producing coherent extreme-ultraviolet (EUV) light, with photon energies up to about 0.5 keV (refs 1, 2). This is achieved by focusing a femtosecond laser into a gas, and high harmonics of the fundamental laser frequency are radiated in the forward direction. However,...

journal_title：Nature

authors： Paul A,Bartels RA,Tobey R,Green H,Weiman S,Christov IP,Murnane MM,Kapteyn HC,Backus S

更新日期：2003-01-02 00:00:00

abstract：:Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...

journal_title：Nature

authors： Dingle EH,Attal M,Sinclair HD

更新日期：2017-04-26 00:00:00

abstract：:Nuclear import of the NF-AT transcription factors during T-cell activation requires the calcium-activated phosphatase calcineurin, which unmasks nuclear-location signals on NF-AT. We show here that the nuclear import of NF-ATs is not sufficient to activate NF-AT target genes, as NF-ATs are subject to a futile cycling ...

journal_title：Nature

authors： Zhu J,McKeon F

更新日期：1999-03-18 00:00:00

abstract：:Multiplicative operations are important in sensory processing, but their biophysical implementation remains largely unknown. We investigated an identified neuron (the lobula giant movement detector, LGMD, of locusts) whose output firing rate in response to looming visual stimuli has been described by two models, one o...

journal_title：Nature

authors： Gabbiani F,Krapp HG,Koch C,Laurent G

更新日期：2002-11-21 00:00:00

abstract：:A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal s...

journal_title：Nature

authors： Saper CB,Scammell TE,Lu J

更新日期：2005-10-27 00:00:00

abstract：:In developing mammalian muscle, axon branches of several motor neurons co-innervate the same muscle fibre. Competition among them results in the strengthening of one and the withdrawal of the rest. It is not known why one particular axon branch survives or why some competitions resolve sooner than others. Here we show...

journal_title：Nature

authors： Kasthuri N,Lichtman JW

更新日期：2003-07-24 00:00:00

abstract：:An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...

journal_title：Nature

authors： Movshovich R,Bianchi A,Capan C,Jaime M,Goodrich RG

更新日期：2004-02-26 00:00:00

abstract：:Over 200 recessive X chromosome-linked diseases, typically affecting only hemizygous males, have been identified. In many of these, prenatal diagnosis is possible by chorion villus sampling (CVS) or amniocentesis, followed by cytogenetic, biochemical or molecular analysis of the cells recovered from the conceptus. In ...

journal_title：Nature

authors： Handyside AH,Kontogianni EH,Hardy K,Winston RM

更新日期：1990-04-19 00:00:00

abstract：:Fluids and melts liberated from subducting oceanic crust recycle lithophile elements back into the mantle wedge, facilitate melting and ultimately lead to prolific subduction-zone arc volcanism. The nature and composition of the mobile phases generated in the subducting slab at high pressures have, however, remained l...

journal_title：Nature

authors： Kessel R,Schmidt MW,Ulmer P,Pettke T

更新日期：2005-09-29 00:00:00

abstract：:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, c...

journal_title：Nature

authors： Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

更新日期：2004-02-19 00:00:00

abstract：:This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...

journal_title：Nature

authors： Silberberg D,Anand NP,Michels K,Kalaria RN

更新日期：2015-11-19 00:00:00

abstract：:Magnetic surveys of the martian surface have revealed significantly lower magnetic field intensities over the gigantic impact craters Hellas and Argyre than over surrounding regions. The reduced fields are commonly attributed to pressure demagnetization caused by shock waves generated during meteorite impact, in the a...

journal_title：Nature

authors： Carporzen L,Gilder SA,Hart RJ

更新日期：2005-05-12 00:00:00

abstract：:The generation of a double-strand break in the Saccharomyces cerevisiae genome is a potentially catastrophic event that can induce cell-cycle arrest or ultimately result in loss of cell viability. The repair of such lesions is strongly dependent on proteins encoded by the RAD52 epistasis group of genes (RAD50-55, RAD5...

journal_title：Nature

authors： New JH,Sugiyama T,Zaitseva E,Kowalczykowski SC

更新日期：1998-01-22 00:00:00

abstract：:In the Northern Hemisphere, ozone levels in the troposphere have increased by 35 per cent over the past century, with detrimental impacts on forest and agricultural productivity, even when forest productivity has been stimulated by increased carbon dioxide levels. In addition to reducing productivity, increased tropos...

journal_title：Nature

authors： Loya WM,Pregitzer KS,Karberg NJ,King JS,Giardina CP

更新日期：2003-10-16 00:00:00

abstract：:Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summ...

journal_title：Nature

authors： Tedstone AJ,Nienow PW,Gourmelen N,Dehecq A,Goldberg D,Hanna E

更新日期：2015-10-29 00:00:00

abstract：:Highly collimated parsec-scale jets, which are generally linked to the presence of an accretion disk, are commonly observed in low-mass young stellar objects. In the past two decades, a few of these jets have been directly (or indirectly) observed from higher-mass (larger than eight solar masses) young stellar objects...

journal_title：Nature

authors： McLeod AF,Reiter M,Kuiper R,Klaassen PD,Evans CJ

更新日期：2018-02-15 00:00:00

abstract：:Groundwater drawn daily from shallow alluvial sands by millions of wells over large areas of south and southeast Asia exposes an estimated population of over a hundred million people to toxic levels of arsenic. Holocene aquifers are the source of widespread arsenic poisoning across the region. In contrast, Pleistocene...

journal_title：Nature

authors： van Geen A,Bostick BC,Pham TK,Vi ML,Nguyen-Ngoc M,Phu DM,Pham HV,Radloff K,Aziz Z,Mey JL,Stahl MO,Harvey CF,Oates P,Weinman B,Stengel C,Frei F,Kipfer R,Berg M

更新日期：2013-09-12 00:00:00

abstract：:The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition...

journal_title：Nature

authors： Bredemeyer AL,Sharma GG,Huang CY,Helmink BA,Walker LM,Khor KC,Nuskey B,Sullivan KE,Pandita TK,Bassing CH,Sleckman BP

更新日期：2006-07-27 00:00:00

abstract：:THE cause of extinction of the woolly mammoth, Mammuthus primigenius (Blumenbach), is still debated. A major environmental change at the Pleistocene-Holocene boundary, hunting by early man, or both together are among the main explanations that have been suggested. But hardly anyone has doubted that mammoths had become...

journal_title：Nature

authors： Vartanyan SL,Garutt VE,Sher AV

更新日期：1993-03-25 00:00:00

abstract：:Serious concerns have been raised about the ecological effects of industrialized fishing, spurring a United Nations resolution on restoring fisheries and marine ecosystems to healthy levels. However, a prerequisite for restoration is a general understanding of the composition and abundance of unexploited fish communit...

journal_title：Nature

authors： Myers RA,Worm B

更新日期：2003-05-15 00:00:00

abstract：:The factors determining disease severity in malaria are complex and include host polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and ...

journal_title：Nature

authors： Rowe JA,Moulds JM,Newbold CI,Miller LH

更新日期：1997-07-17 00:00:00

abstract：:The TGF-beta/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila and the related Sma genes from Caenorhabditis elegans have been genetically implicated in signalling by membe...

journal_title：Nature

authors： Liu F,Hata A,Baker JC,Doody J,Cárcamo J,Harland RM,Massagué J

更新日期：1996-06-13 00:00:00

abstract：:Animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane, attributes that profoundly affect stability, transmission and immune recognition. Among those lacking an envelope, the Picornaviridae are a large and diverse family of positive-strand RNA...

journal_title：Nature

authors： Feng Z,Hensley L,McKnight KL,Hu F,Madden V,Ping L,Jeong SH,Walker C,Lanford RE,Lemon SM

更新日期：2013-04-18 00:00:00