Pathology: cancer cells compress intratumour vessels.

Abstract:

:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.

journal_name

Nature

journal_title

Nature

authors

Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

doi

10.1038/427695a

keywords:

subject

Has Abstract

pub_date

2004-02-19 00:00:00

pages

695

issue

6976

eissn

0028-0836

issn

1476-4687

pii

427695a

journal_volume

427

pub_type

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