Abstract:
:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.
journal_name
Naturejournal_title
Natureauthors
Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RKdoi
10.1038/427695akeywords:
subject
Has Abstractpub_date
2004-02-19 00:00:00pages
695issue
6976eissn
0028-0836issn
1476-4687pii
427695ajournal_volume
427pub_type
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