Abstract：
:The factors determining disease severity in malaria are complex and include host polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and form rosettes. The molecular basis of resetting is not well understood, although a group of low-molecular-mass proteins called rosettins have been described as potential parasite ligands. Infected erythrocytes also bind to endothelial cells, and this interaction is mediated by the parasite-derived variant erythrocyte membrane protein PfEMP1, which is encoded by the var gene family. Here we report that the parasite ligand for rosetting in a P. falciparum clone is PfEMP1, encoded by a specific var gene. We also report that complement-receptor 1 (CR1) on erythrocytes plays a role in the formation of rosettes and that erythrocytes with a common African CR1 polymorphism (S1(a-)) have reduced adhesion to the domain of PfEMP1 that binds normal erythrocytes. Thus we describe a new adhesive function for PfEMP1 and raise the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria.
journal_name
Naturejournal_title
Natureauthors
Rowe JA,Moulds JM,Newbold CI,Miller LHdoi
10.1038/40888subject
Has Abstractpub_date
1997-07-17 00:00:00pages
292-5issue
6639eissn
0028-0836issn
1476-4687journal_volume
388pub_type
杂志文章相关文献
NATURE文献大全abstract：:Only three elements are ferromagnetic at room temperature: the transition metals iron, cobalt and nickel. The Stoner criterion explains why iron is ferromagnetic but manganese, for example, is not, even though both elements have an unfilled 3d shell and are adjacent in the periodic table: according to this criterion, ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14621
更新日期：2015-08-06 00:00:00
abstract：:The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacin...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/30251
更新日期：1998-05-14 00:00:00
abstract：:7SL RNA is an abundant cytoplasmic RNA which functions in protein secretion as a component of the signal recognition particle. Alu sequences are the most abundant family of human and rodent middle repetitive DNA sequences (reviewed in ref. 2). The primary structure of human 7SL RNA consists of an Alu sequence interrup...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/312171a0
更新日期：1984-11-08 00:00:00
abstract：:Wetlands are the largest natural source of atmospheric methane, the second most important greenhouse gas. Methane flux to the atmosphere depends strongly on the climate; however, by far the largest part of the methane formed in wetland ecosystems is recycled and does not reach the atmosphere. The biogeochemical contro...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03802
更新日期：2005-08-25 00:00:00
abstract：:Gravitational lensing is a powerful tool for the study of the distribution of dark matter in the Universe. The cold-dark-matter model of the formation of large-scale structures (that is, clusters of galaxies and even larger assemblies) predicts the existence of quasars gravitationally lensed by concentrations of dark ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02153
更新日期：2003-12-18 00:00:00
abstract：:The properties of synapses between retinal neurons make an essential contribution to early visual processing. Light produces a graded hyperpolarization in photoreceptors, up to 25 mV in amplitude, and it is conventionally assumed that all of this response range is available for coding visual information. We report her...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/328522a0
更新日期：1987-08-06 00:00:00
abstract：:Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible reactions in the target sequence, such as photocrosslinking or cleavag...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/344358a0
更新日期：1990-03-22 00:00:00
abstract：:Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequence...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-1961-1
更新日期：2020-02-01 00:00:00
abstract：:The neutron superfluid in most neutron stars should be in a highly turbulent state. If so, this turbulence drastically alters its rotational properties. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/227791a0
更新日期：1970-08-22 00:00:00
abstract：:A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-depende...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/346369a0
更新日期：1990-07-26 00:00:00
abstract：:Halobacterium halobium is an obligately halophilic archaebacterium of interest to molecular biologists for many reasons, one of which is the unexplained high frequency (10(-4)-10(-2) mutants per cell plated) at which it yields readily identifiable and unstable mutants. We showed previously that the genome of H. halobi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/299182a0
更新日期：1982-09-09 00:00:00
abstract：:Very large collisions in the asteroid belt could lead temporarily to a substantial increase in the rate of impacts of meteorites on Earth. Orbital simulations predict that fragments from such events may arrive considerably faster than the typical transit times of meteorites falling today, because in some large impacts...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02736
更新日期：2004-07-15 00:00:00
abstract：:Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22039
更新日期：2017-04-26 00:00:00
abstract：:Helium is used as a critical tracer throughout the Earth sciences, where its relatively simple isotopic systematics is used to trace degassing from the mantle, to date groundwater and to time the rise of continents. The hydrothermal system at Yellowstone National Park is famous for its high helium-3/helium-4 isotope r...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12992
更新日期：2014-02-20 00:00:00
abstract：:Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20099
更新日期：2016-11-03 00:00:00
abstract：:At fertilization, an increase of cytosolic calcium ions (Ca2+) triggers various activation responses in animal eggs. In vertebrates, these responses include exit from metaphase arrest in meiosis II (MII exit) and cortical remodelling initiated by cortical granule exocytosis. Although the essential requirement of Ca2+/...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06136
更新日期：2007-09-20 00:00:00
abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/340471a0
更新日期：1989-08-10 00:00:00
abstract：:Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2732-8
更新日期：2020-09-01 00:00:00
abstract：:Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/32170
更新日期：1998-03-05 00:00:00
abstract：:Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2632-y
更新日期：2020-08-01 00:00:00
abstract：:Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/335815a0
更新日期：1988-10-27 00:00:00
abstract：:The mechanism whereby eukaryotic pre-messenger RNAs are polyadenylated is unknown. Most models for polyadenylation invoke cleavage of precursor transcripts at the site of poly(A) addition followed by polymerization of A residues by poly(A) polymerase. Analysis of the sequences surrounding poly(A) addition sites has id...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/309179a0
更新日期：1984-05-10 00:00:00
abstract：:The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09278
更新日期：2010-08-05 00:00:00
abstract：:Fas is a type-I membrane protein that transduces an apoptotic signal. Binding of Fas ligand or agonistic anti-Fas antibody to Fas kills the cells by apoptosis. Studies in the nematode Caenorhabditis elegans have suggested that proteases such as interleukin-1 beta-converting enzyme (ICE) or the product of the C. elegan...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/375078a0
更新日期：1995-05-04 00:00:00
abstract：:A timescale is necessary for estimating rates of molecular and morphological change in organisms and for interpreting patterns of macroevolution and biogeography. Traditionally, these times have been obtained from the fossil record, where the earliest representatives of two lineages establish a minimum time of diverge...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/31927
更新日期：1998-04-30 00:00:00
abstract：:Concentrations of dissolved oxygen in the ocean seem to correlate well with climate instabilities over the past 100,000 years. For example, the concentration of dissolved oxygen in Pacific intermediate waters was considerably higher during Pleistocene glacial periods than it is today. This has been inferred from the p...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35030084
更新日期：2000-09-21 00:00:00
abstract：:TATA-binding protein (TBP) binds the minor groove of the TATA element with the DNA bent 80 degrees towards the major groove. A constrained minicircle strategy has been used to test the effect of DNA topology on the affinity of TBP for the TATA element. We report here that TBP bound to DNA which was slightly pre-bent t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/373724a0
更新日期：1995-02-23 00:00:00
abstract：:Although the influence of electrical activity on neural development has been studied extensively, experiments have only recently focused on the role of activity in the development of the mammalian central nervous system (CNS). Using tetrodotoxin (TTX) to abolish sodium-mediated action potentials, studies on the visual...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/323156a0
更新日期：1986-09-11 00:00:00
abstract：:The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03959
更新日期：2005-09-15 00:00:00
abstract：:Methane is an important greenhouse gas that is emitted from multiple natural and anthropogenic sources. Atmospheric methane concentrations have varied on a number of timescales in the past, but what has caused these variations is not always well understood. The different sources and sinks of methane have specific isot...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature11461
更新日期：2012-10-04 00:00:00
