Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1.

abstract：:Alkaloids, secondary metabolites that contain basic nitrogen atoms, are some of the most well-known biologically active natural products in chemistry and medicine. Although efficient laboratory synthesis of alkaloids would enable the study and optimization of their biological properties, their preparation is often com...

journal_title：Nature

authors： Parr BT,Economou C,Herzon SB

更新日期：2015-09-24 00:00:00

abstract：:For many decades comparative analyses of protein sequences and structures have been used to investigate fundamental principles of molecular evolution. In contrast, relatively little is known about the long-term evolution of species' phenotypic and genetic properties. This represents an important gap in our understandi...

journal_title：Nature

authors： Plata G,Henry CS,Vitkup D

更新日期：2015-01-15 00:00:00

abstract：:Population-level analyses often use average quantities to describe heterogeneous systems, particularly when variation does not arise from identifiable groups. A prominent example, central to our current understanding of epidemic spread, is the basic reproductive number, R(0), which is defined as the mean number of inf...

journal_title：Nature

authors： Lloyd-Smith JO,Schreiber SJ,Kopp PE,Getz WM

更新日期：2005-11-17 00:00:00

abstract：:Multiple sclerosis is commonly associated with a local humoral immune response within the central nervous system. A hallmark of this intrathecal response is the presence of electrophoretically demonstrable oligoclonal bands of IgG in the cerebrospinal fluid (CSF) of up to 95% of patients. Observations indicating that ...

journal_title：Nature

authors： Vandvik B,Norrby E

更新日期：1989-04-27 00:00:00

abstract：:Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium. Afterglow polarization directly probes the magnetic properties of the jet when measured mi...

journal_title：Nature

authors： Wiersema K,Covino S,Toma K,van der Horst AJ,Varela K,Min M,Greiner J,Starling RL,Tanvir NR,Wijers RA,Campana S,Curran PA,Fan Y,Fynbo JP,Gorosabel J,Gomboc A,Götz D,Hjorth J,Jin ZP,Kobayashi S,Kouveliotou C,Munde

更新日期：2014-05-08 00:00:00

abstract：:A hemispheric dichotomy on Mars is marked by the sharp contrast between the sparsely cratered northern lowland plains and the heavily cratered southern highlands. Mechanisms proposed to remove ancient crust or form younger lowland crust include one or more giant impacts, subcrustal transport by mantle convection, the ...

journal_title：Nature

authors： Watters TR,Leuschen CJ,Plaut JJ,Picardi G,Safaeinili A,Clifford SM,Farrell WM,Ivanov AB,Phillips RJ,Stofan ER

更新日期：2006-12-14 00:00:00

abstract：:The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research. However, little evidence exists that the viral reservoir can be sufficiently targeted to improve virologic control following discontinuation of antiretroviral therapy. Here ...

journal_title：Nature

authors： Borducchi EN,Cabral C,Stephenson KE,Liu J,Abbink P,Ng'ang'a D,Nkolola JP,Brinkman AL,Peter L,Lee BC,Jimenez J,Jetton D,Mondesir J,Mojta S,Chandrashekar A,Molloy K,Alter G,Gerold JM,Hill AL,Lewis MG,Pau MG,Schuit

更新日期：2016-12-08 00:00:00

abstract：:Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to persistent atopic asthma, which may not manifest for several years, is restricted to only a subset of atopics. The key to establishing the link between atopy and a...

journal_title：Nature

authors： Holt PG,Macaubas C,Stumbles PA,Sly PD

更新日期：1999-11-25 00:00:00

abstract：:Cognitive ethology focuses on the study of animals under natural conditions to reveal ecologically adapted modes of learning. But biologists can more easily study what an animal learns than how it learns. For example, honeybees take repeated 'orientation' flights before becoming foragers at about three weeks of age. T...

journal_title：Nature

authors： Capaldi EA,Smith AD,Osborne JL,Fahrbach SE,Farris SM,Reynolds DR,Edwards AS,Martin A,Robinson GE,Poppy GM,Riley JR

更新日期：2000-02-03 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPs) are vital for regulating tryosine phosphorylation in many processes, including growth and differentiation. The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on the crystal structure of RPTPalpha domain 1 we have proposed that dimerization can ...

journal_title：Nature

authors： Jiang G,den Hertog J,Su J,Noel J,Sap J,Hunter T

更新日期：1999-10-07 00:00:00

abstract：:The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathw...

journal_title：Nature

authors： Viré E,Brenner C,Deplus R,Blanchon L,Fraga M,Didelot C,Morey L,Van Eynde A,Bernard D,Vanderwinden JM,Bollen M,Esteller M,Di Croce L,de Launoit Y,Fuks F

更新日期：2006-02-16 00:00:00

abstract：:It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure. AVP administered subcutaneously (s.c.), intraventricularly or intracerebrally can prolong extinction of acti...

journal_title：Nature

authors： Koob GF,Dantzer R,Rodriguez F,Bloom FE,Le Moal M

更新日期：1985-06-27 00:00:00

abstract：:Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. However, the molecular mechanism by which TET family enzymes regulate gene transcription remains elusive. Using protein affinity purification, here we search for f...

journal_title：Nature

authors： Chen Q,Chen Y,Bian C,Fujiki R,Yu X

更新日期：2013-01-24 00:00:00

abstract：:Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase, EC 1.14.16.1). PKU is a common inborn error of amino-acid metabolism in caucasian populations and approximately 1 in 50 individuals are carriers of a P...

journal_title：Nature

authors： DiLella AG,Marvit J,Brayton K,Woo SL

更新日期：1987-05-28 00:00:00

abstract：:Measurements of the cosmic microwave background (CMB) radiation can reveal with remarkable precision the conditions of the Universe when it was approximately 400,000 years old. The three most fundamental properties of the CMB are its frequency spectrum (which determines the temperature), and the fluctuations in both t...

journal_title：Nature

authors： Leitch EM,Kovac JM,Pryke C,Carlstrom JE,Halverson NW,Holzapfel WL,Dragovan M,Reddall B,Sandberg ES

更新日期：2002-12-19 00:00:00

abstract：:A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. We report the crystal structure of the complex from Methanococcus jannaschii at a resolution of 3.2 A. The structure suggests ...

journal_title：Nature

authors： Van den Berg B,Clemons WM Jr,Collinson I,Modis Y,Hartmann E,Harrison SC,Rapoport TA

更新日期：2004-01-01 00:00:00

abstract：:Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts. In steady-state, HSCs remain largely quiescent and self-renew at a constant low rate, forestalling their exhaustion during adult ...

journal_title：Nature

authors： Hock H,Hamblen MJ,Rooke HM,Schindler JW,Saleque S,Fujiwara Y,Orkin SH

更新日期：2004-10-21 00:00:00

abstract：:We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the surface of cultured human haematopoietic cell lines by means of a monoclonal antibody. Although it is expressed on all cultured human haematopoietic cell lines te...

journal_title：Nature

authors： Omary MB,Trowbridge IS,Minowada J

更新日期：1980-08-28 00:00:00

abstract：:Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is ach...

journal_title：Nature

authors： Krogsgaard M,Li QJ,Sumen C,Huppa JB,Huse M,Davis MM

更新日期：2005-03-10 00:00:00

abstract：:Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...

journal_title：Nature

authors： Witkowski FX,Leon LJ,Penkoske PA,Giles WR,Spano ML,Ditto WL,Winfree AT

更新日期：1998-03-05 00:00:00

abstract：:In standard fluid dynamics, the density change associated with flow is often assumed to be negligible, implying that the fluid is incompressible. For example, this has been established for simple shear flows, where no pressure change is associated with flow: there is no volume deformation due to viscous stress and ine...

journal_title：Nature

authors： Furukawa A,Tanaka H

更新日期：2006-09-28 00:00:00

abstract：:The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control...

journal_title：Nature

authors： Sawamiphak S,Seidel S,Essmann CL,Wilkinson GA,Pitulescu ME,Acker T,Acker-Palmer A

更新日期：2010-05-27 00:00:00

abstract：:High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....

journal_title：Nature

authors： Balakirev FF,Betts JB,Migliori A,Ono S,Ando Y,Boebinger GS

更新日期：2003-08-21 00:00:00

abstract：:In the cores of some clusters of galaxies the hot intracluster plasma is dense enough that it should cool radiatively in the cluster's lifetime, leading to continuous 'cooling flows' of gas sinking towards the cluster centre, yet no such cooling flow has been observed. The low observed star-formation rates and cool ga...

journal_title：Nature

authors： McDonald M,Bayliss M,Benson BA,Foley RJ,Ruel J,Sullivan P,Veilleux S,Aird KA,Ashby ML,Bautz M,Bazin G,Bleem LE,Brodwin M,Carlstrom JE,Chang CL,Cho HM,Clocchiatti A,Crawford TM,Crites AT,de Haan T,Desai S,Dobbs M

更新日期：2012-08-16 00:00:00

abstract：:Apoptosis in the immune system is a fundamental process regulating lymphocyte maturation, receptor repertoire selection and homeostasis. Thus, death by apoptosis is as essential for the function of lymphocytes as growth and differentiation. This article focuses on death receptor-associated apoptosis and the role of CD...

journal_title：Nature

authors： Krammer PH

更新日期：2000-10-12 00:00:00

abstract：:Nanoscale electronic devices made from carbon nanotubes, such as transistors and sensors, are much smaller and more versatile than those that rely on conventional microelectronic chips, but their development for mass production has been thwarted by difficulties in aligning and integrating the millions of nanotubes req...

journal_title：Nature

authors： Rao SG,Huang L,Setyawan W,Hong S

更新日期：2003-09-04 00:00:00

abstract：: ...

journal_title：Nature

authors： Lewis-Jones H

更新日期：2018-11-01 00:00:00

abstract：:Occupancy of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. Thi...

journal_title：Nature

authors： Harding FA,McArthur JG,Gross JA,Raulet DH,Allison JP

更新日期：1992-04-16 00:00:00

abstract：:The cyclin-dependent kinases 4 and 6 (Cdk4/6) that control the G1 phase of the cell cycle and their inhibitor, the p16INK4a tumour suppressor, have a central role in cell proliferation and in tumorigenesis. The structures of Cdk6 bound to p16INK4a and to the related p19INK4d reveal that the INK4 inhibitors bind next t...

journal_title：Nature

authors： Russo AA,Tong L,Lee JO,Jeffrey PD,Pavletich NP

更新日期：1998-09-17 00:00:00

abstract：:One of the earliest computational principles attributed to the cerebellum was the measurement of time. This idea was originally suggested on anatomical grounds, and was taken up again to explain some of the deficits in cerebellar patients. The contribution of the cerebellum to eye movements, in contrast, has tradition...

journal_title：Nature

authors： Thier P,Dicke PW,Haas R,Barash S

更新日期：2000-05-04 00:00:00