A massive, cooling-flow-induced starburst in the core of a luminous cluster of galaxies.

abstract：:The four-chambered mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiotemporal patterns of differentiation and contributions to the definitive heart. The first heart field differentiates earlier in lateral plate mesoderm, generates the linear heart tube and ultimately giv...

journal_title：Nature

authors： Zhou Y,Cashman TJ,Nevis KR,Obregon P,Carney SA,Liu Y,Gu A,Mosimann C,Sondalle S,Peterson RE,Heideman W,Burns CE,Burns CG

更新日期：2011-05-29 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease. In particular, hMSH2 and hMLH1 homologues of the bacterial DNA mismatch repair genes mutS and mutL, respectively, were sh...

journal_title：Nature

authors： Nicolaides NC,Papadopoulos N,Liu B,Wei YF,Carter KC,Ruben SM,Rosen CA,Haseltine WA,Fleischmann RD,Fraser CM

更新日期：1994-09-01 00:00:00

abstract：:The restriction of intermingling between specific cell populations is crucial for the maintenance of organized patterns during development. A striking example is the restriction of cell mixing between segments in the insect epidermis and the vertebrate hindbrain that may enable each segment to maintain a distinct iden...

journal_title：Nature

authors： Xu Q,Mellitzer G,Robinson V,Wilkinson DG

更新日期：1999-05-20 00:00:00

abstract：:Deviations from the universal genetic code have been reported for several microorganisms. Termination codons are used for coding some amino acids in Paramecium, Mycoplasma or Tetrahymena, and in Escherichia coli, the UGA termination codon is used to code for selenocysteine. In mitochondria, the changes of sense codons...

journal_title：Nature

authors： Kawaguchi Y,Honda H,Taniguchi-Morimura J,Iwasaki S

更新日期：1989-09-14 00:00:00

abstract：:Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...

journal_title：Nature

authors： Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

更新日期：2015-06-11 00:00:00

abstract：:Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts. In steady-state, HSCs remain largely quiescent and self-renew at a constant low rate, forestalling their exhaustion during adult ...

journal_title：Nature

authors： Hock H,Hamblen MJ,Rooke HM,Schindler JW,Saleque S,Fujiwara Y,Orkin SH

更新日期：2004-10-21 00:00:00

abstract：:The receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction. Igf2/Mpr has been mapped to the mouse Tme locus and shown to be an imprinte...

journal_title：Nature

authors： Wang ZQ,Fung MR,Barlow DP,Wagner EF

更新日期：1994-12-01 00:00:00

abstract：:Black holes become visible when they accrete gas, a common source of which is a close stellar companion. The standard theory for this process (invoking a 'thin accretion disk') does not explain some spectacular phenomena associated with these systems, such as their X-ray variability and relativistic outflows, indicati...

journal_title：Nature

authors： Kanbach G,Straubmeier C,Spruit HC,Belloni T

更新日期：2001-11-08 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering a...

journal_title：Nature

authors： Tanaka M,Sackmann E

更新日期：2005-09-29 00:00:00

abstract：:Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. M...

journal_title：Nature

authors： Holmes E,Loo RL,Stamler J,Bictash M,Yap IK,Chan Q,Ebbels T,De Iorio M,Brown IJ,Veselkov KA,Daviglus ML,Kesteloot H,Ueshima H,Zhao L,Nicholson JK,Elliott P

更新日期：2008-05-15 00:00:00

abstract：:A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...

journal_title：Nature

authors： Nguyen NUN,Canseco DC,Xiao F,Nakada Y,Li S,Lam NT,Muralidhar SA,Savla JJ,Hill JA,Le V,Zidan KA,El-Feky HW,Wang Z,Ahmed MS,Hubbi ME,Menendez-Montes I,Moon J,Ali SR,Le V,Villalobos E,Mohamed MS,Elhelaly WM,Thet

更新日期：2020-06-01 00:00:00

abstract：:In budding yeast many genes are expressed under cell-cycle control in late G1. These include a large group of DNA synthesis genes, the HO gene involved in mating-type switching, CTS1 (chitinase) and also CLN1 and CLN2 (ref. 4) encoding G1 cyclins. Two factors, encoded by the SWI4 and SWI6 genes, are required for HO (r...

journal_title：Nature

authors： Lowndes NF,Johnson AL,Breeden L,Johnston LH

更新日期：1992-06-11 00:00:00

abstract：:Morphogens act in developing tissues to control the spatial arrangement of cellular differentiation. The activity of a morphogen has generally been viewed as a concentration-dependent response to a diffusible signal, but the duration of morphogen signalling can also affect cellular responses. One such example is the m...

journal_title：Nature

authors： Dessaud E,Yang LL,Hill K,Cox B,Ulloa F,Ribeiro A,Mynett A,Novitch BG,Briscoe J

更新日期：2007-11-29 00:00:00

abstract：:Oxygen, one of the most abundant elements on Earth, often forms an undesired interstitial impurity or ceramic phase (such as an oxide particle) in metallic materials. Even when it adds strength, oxygen doping renders metals brittle1-3. Here we show that oxygen can take the form of ordered oxygen complexes, a state in ...

journal_title：Nature

authors： Lei Z,Liu X,Wu Y,Wang H,Jiang S,Wang S,Hui X,Wu Y,Gault B,Kontis P,Raabe D,Gu L,Zhang Q,Chen H,Wang H,Liu J,An K,Zeng Q,Nieh TG,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:Neuronal circuits across several systems display remarkable plasticity to sensory input during postnatal development. Experience-dependent refinements are often restricted to well-defined critical periods in early life, but how these are established remains mostly unknown. A representative example is the loss of respo...

journal_title：Nature

authors： Fagiolini M,Hensch TK

更新日期：2000-03-09 00:00:00

abstract：:Many collective human activities, including violence, have been shown to exhibit universal patterns. The size distributions of casualties both in whole wars from 1816 to 1980 and terrorist attacks have separately been shown to follow approximate power-law distributions. However, the possibility of universal patterns r...

journal_title：Nature

authors： Bohorquez JC,Gourley S,Dixon AR,Spagat M,Johnson NF

更新日期：2009-12-17 00:00:00

abstract：:A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-depende...

journal_title：Nature

authors： Slot JW,Moxley R,Geuze HJ,James DE

更新日期：1990-07-26 00:00:00

abstract：:Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...

journal_title：Nature

authors： Yasui M,Hazama A,Kwon TH,Nielsen S,Guggino WB,Agre P

更新日期：1999-11-11 00:00:00

abstract：:The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) c...

journal_title：Nature

authors： Brunet JF,Denizot F,Luciani MF,Roux-Dosseto M,Suzan M,Mattei MG,Golstein P

更新日期：1987-07-16 00:00:00

abstract：:The proteins encoded by the ras oncogene are thought to trigger expression of the transformed phenotype in some types of cancer cells. In human cells, the ras protein family consists of several members including normal (proto-oncogene) and mutant (oncogene) forms. In general, the proto-oncogene forms are thought to be...

journal_title：Nature

authors： Feramisco JR,Clark R,Wong G,Arnheim N,Milley R,McCormick F

更新日期：1985-04-18 00:00:00

abstract：:The intestinal tract maintains proper function by replacing aged cells with freshly produced cells that arise from a population of self-renewing intestinal stem cells (ISCs). In the mammalian intestine, ISC self renewal, amplification and differentiation take place along the crypt-villus axis, and are controlled by th...

journal_title：Nature

authors： Takashima S,Mkrtchyan M,Younossi-Hartenstein A,Merriam JR,Hartenstein V

更新日期：2008-07-31 00:00:00

abstract：:The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...

journal_title：Nature

authors： Kozono H,White J,Clements J,Marrack P,Kappler J

更新日期：1994-05-12 00:00:00

abstract：:Digital organisms are computer programs that self-replicate, mutate and adapt by natural selection. They offer an opportunity to test generalizations about living systems that may extend beyond the organic life that biologists usually study. Here we have generated two classes of digital organism: simple programs selec...

journal_title：Nature

authors： Lenski RE,Ofria C,Collier TC,Adami C

更新日期：1999-08-12 00:00:00

abstract：:It is thought that in skeletal muscle excitation-contraction (EC) coupling, the release of Ca2+ from the sarcoplasmic reticulum is controlled by the dihydropyridine (DHP) receptor in the transverse tubular membrane, where it serves as the voltage sensor. We have shown previously that injection of an expression plasmid...

journal_title：Nature

authors： Tanabe T,Beam KG,Adams BA,Niidome T,Numa S

更新日期：1990-08-09 00:00:00

abstract：:A 7-A resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, alpha-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the s...

journal_title：Nature

authors： Henderson R,Unwin PN

更新日期：1975-09-04 00:00:00

abstract：:As the fraction of electricity generation from intermittent renewable sources--such as solar or wind--grows, the ability to store large amounts of electrical energy is of increasing importance. Solid-electrode batteries maintain discharge at peak power for far too short a time to fully regulate wind or solar power out...

journal_title：Nature

authors： Huskinson B,Marshak MP,Suh C,Er S,Gerhardt MR,Galvin CJ,Chen X,Aspuru-Guzik A,Gordon RG,Aziz MJ

更新日期：2014-01-09 00:00:00

abstract：:Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weak...

journal_title：Nature

authors： von Mering C,Krause R,Snel B,Cornell M,Oliver SG,Fields S,Bork P

更新日期：2002-05-23 00:00:00

abstract：:Accurate measurement of the lifetime of the neutron (which is unstable to beta decay) is important for understanding the weak nuclear force and the creation of matter during the Big Bang. Previous measurements of the neutron lifetime have mainly been limited by certain systematic errors; however, these could in princi...

journal_title：Nature

authors： Huffman PR,Brome CR,Butterworth JS,Coakley KJ,Dewey MS,Dzhosyuk SN,Golub R,Greene GL,Habicht K,Lamoreaux SK,Mattoni CE,McKinsey DN,Wietfeldt FE,Doyle JM

更新日期：2000-01-06 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...

journal_title：Nature

authors： Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,

更新日期：2019-04-01 00:00:00