Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.

abstract：:Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more ...

journal_title：Nature

authors： Huff V,Compton DA,Chao LY,Strong LC,Geiser CF,Saunders GF

更新日期：1988-11-24 00:00:00

abstract：:External agents of mortality (disturbances) occur over a wide range of scales of space and time, and are believed to have large effects on species diversity. The "intermediate disturbance hypothesis", which proposes maximum diversity at intermediate frequencies of disturbance, has received support from both field and ...

journal_title：Nature

authors： Buckling A,Kassen R,Bell G,Rainey PB

更新日期：2000-12-21 00:00:00

abstract：:Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast. However, the function or occurrence of this specific histone mark has not been studied in multicellular e...

journal_title：Nature

authors： Das C,Lucia MS,Hansen KC,Tyler JK

更新日期：2009-05-07 00:00:00

abstract：:We have postulated that an excitatory postsynaptic potential (e.p.s.p.) may open voltage-sensitive K+ ('M') channels, in an appropriate depolarizing range, and that this could alter the e.p.s.p. waveform. Consequently, the fast e.p.s.p. in neurones of sympathetic ganglia, elicited by a nicotinic action of acetylcholin...

journal_title：Nature

authors： Tosaka T,Tasaka J,Miyazaki T,Libet B

更新日期：1983-09-08 00:00:00

abstract：:Myeloid precursors can be grown in vitro in the presence of specific growth factors; however, their expansion is limited by a competing process of terminal differentiation. Proto-oncogenes seem to be involved in cellular proliferation and/or differentiation and may also play a role in the myelopoietic process. Murine ...

journal_title：Nature

authors： Blasi E,Mathieson BJ,Varesio L,Cleveland JL,Borchert PA,Rapp UR

更新日期：1985-12-19 00:00:00

abstract：:Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to persistent atopic asthma, which may not manifest for several years, is restricted to only a subset of atopics. The key to establishing the link between atopy and a...

journal_title：Nature

authors： Holt PG,Macaubas C,Stumbles PA,Sly PD

更新日期：1999-11-25 00:00:00

abstract：:During cellular translation of messenger RNAs by ribosomes, the translation apparatus sometimes pauses or stalls at the elongation and termination steps. With the exception of programmed stalling, which is usually used by cells for regulatory purposes, ribosomes stalled on mRNAs need to be terminated and recycled to m...

journal_title：Nature

authors： Ma C,Kurita D,Li N,Chen Y,Himeno H,Gao N

更新日期：2017-01-26 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...

journal_title：Nature

authors： Patzelt C,Tager HS,Carroll RJ,Steiner DF

更新日期：1979-11-15 00:00:00

abstract：:Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5' side ('upstream') of c-myc in the same transcriptional ori...

journal_title：Nature

authors： Payne GS,Bishop JM,Varmus HE

更新日期：1982-01-21 00:00:00

abstract：:More than 99 per cent of the roughly 58,000 living vertebrate species have jaws. This major clade, whose members are collectively known as gnathostomes ('jawed mouths'), made its earliest definitive appearance in the Silurian period, 444-416 million years (Myr) ago, with both the origin of the modern (crown-group) rad...

journal_title：Nature

authors： Anderson PS,Friedman M,Brazeau MD,Rayfield EJ

更新日期：2011-07-06 00:00:00

abstract：:A fundamental tenet of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles. Although several exceptions to this principle are known, all represent specialized cases that are mechanistically rest...

journal_title：Nature

authors： Lolle SJ,Victor JL,Young JM,Pruitt RE

更新日期：2005-03-24 00:00:00

abstract：:The UK Farm-Scale Evaluations (FSE) compared the effects on biodiversity of management of genetically modified herbicide-tolerant (GMHT) spring-sown crops with conventional crop management. The FSE reported larger weed abundance under GMHT management for fodder maize, one of three crops studied. Increased seed product...

journal_title：Nature

authors： Perry JN,Firbank LG,Champion GT,Clark SJ,Heard MS,May MJ,Hawes C,Squire GR,Rothery P,Woiwod IP,Pidgeon JD

更新日期：2004-03-18 00:00:00

abstract：:The E6 oncoprotein derived from tumour-associated human papillomaviruses (HPVs) binds to and induces the degradation of the cellular tumour-suppressor protein p53. A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72. The effect of t...

journal_title：Nature

authors： Storey A,Thomas M,Kalita A,Harwood C,Gardiol D,Mantovani F,Breuer J,Leigh IM,Matlashewski G,Banks L

更新日期：1998-05-21 00:00:00

abstract：:Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population. Despite the frequency, neither the mechanisms of valve calcification nor the developmental origin of a tw...

journal_title：Nature

authors： Garg V,Muth AN,Ransom JF,Schluterman MK,Barnes R,King IN,Grossfeld PD,Srivastava D

更新日期：2005-09-08 00:00:00

abstract：:Mammalian sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis. Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two d...

journal_title：Nature

authors： Gough NM,Gearing DP,Nicola NA,Baker E,Pritchard M,Callen DF,Sutherland GR

更新日期：1990-06-21 00:00:00

abstract：:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...

journal_title：Nature

authors： Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

更新日期：1991-02-21 00:00:00

abstract：:The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, ma...

journal_title：Nature

authors： Pabo CO,Lewis M

更新日期：1982-07-29 00:00:00

abstract：:ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by...

journal_title：Nature

authors： Pebay-Peyroula E,Dahout-Gonzalez C,Kahn R,Trézéguet V,Lauquin GJ,Brandolin G

更新日期：2003-11-06 00:00:00

abstract：:Segmentation of the vertebrate hindbrain into rhombomeres is important for the anterior-posterior arrangement of cranial motor nuclei and efferent nerves. Underlying this reiterated organization, Hox genes display segmentally restricted domains of expression, such as expression of Hoxb-1 (refs 5, 6) in rhombomere 4 (r...

journal_title：Nature

authors： Studer M,Lumsden A,Ariza-McNaughton L,Bradley A,Krumlauf R

更新日期：1996-12-19 00:00:00

abstract：:China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...

journal_title：Nature

authors： Piao S,Ciais P,Huang Y,Shen Z,Peng S,Li J,Zhou L,Liu H,Ma Y,Ding Y,Friedlingstein P,Liu C,Tan K,Yu Y,Zhang T,Fang J

更新日期：2010-09-02 00:00:00

abstract：:Reorganizations of the Atlantic meridional overturning circulation were associated with large and abrupt climatic changes in the North Atlantic region during the last glacial period. Projections with climate models suggest that similar reorganizations may also occur in response to anthropogenic global warming. Here I ...

journal_title：Nature

authors： Schmittner A

更新日期：2005-03-31 00:00:00

abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...

journal_title：Nature

authors： DiTullio GR,Grebmeier JM,Arrigo KR,Lizotte MP,Robinson DH,Leventer A,Barry JP,VanWoert ML,Dunbar RB

更新日期：2000-04-06 00:00:00

abstract：:Water availability limits plant growth and production in almost all terrestrial ecosystems. However, biomes differ substantially in sensitivity of aboveground net primary production (ANPP) to between-year variation in precipitation. Average rain-use efficiency (RUE; ANPP/precipitation) also varies between biomes, supp...

journal_title：Nature

authors： Huxman TE,Smith MD,Fay PA,Knapp AK,Shaw MR,Loik ME,Smith SD,Tissue DT,Zak JC,Weltzin JF,Pockman WT,Sala OE,Haddad BM,Harte J,Koch GW,Schwinning S,Small EE,Williams DG

更新日期：2004-06-10 00:00:00

abstract：:Self-propagating beta-sheet-rich protein aggregates are implicated in a wide range of protein-misfolding phenomena, including amyloid diseases and prion-based inheritance. Two properties have emerged as common features of amyloids. Amyloid formation is ubiquitous: many unrelated proteins form such aggregates and even ...

journal_title：Nature

authors： Chien P,DePace AH,Collins SR,Weissman JS

更新日期：2003-08-21 00:00:00

abstract：:Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...

journal_title：Nature

authors： Kum HS,Lee H,Kim S,Lindemann S,Kong W,Qiao K,Chen P,Irwin J,Lee JH,Xie S,Subramanian S,Shim J,Bae SH,Choi C,Ranno L,Seo S,Lee S,Bauer J,Li H,Lee K,Robinson JA,Ross CA,Schlom DG,Rzchowski MS,Eom CB,Kim J

更新日期：2020-02-01 00:00:00

abstract：:Owing to their scientific and technological importance, inorganic single crystals with highly reactive surfaces have long been studied. Unfortunately, surfaces with high reactivity usually diminish rapidly during the crystal growth process as a result of the minimization of surface energy. A typical example is titaniu...

journal_title：Nature

authors： Yang HG,Sun CH,Qiao SZ,Zou J,Liu G,Smith SC,Cheng HM,Lu GQ

更新日期：2008-05-29 00:00:00

abstract：:Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...

journal_title：Nature

authors： Pasztor VM,Bush BM

更新日期：1987-04-23 00:00:00

abstract：:A list of authors and their affiliations appears at the end of the paper New-particle formation is a major contributor to urban smog1,2, but how it occurs in cities is often puzzling3. If the growth rates of urban particles are similar to those found in cleaner environments (1-10 nanometres per hour), then existing un...

journal_title：Nature

authors： Wang M,Kong W,Marten R,He XC,Chen D,Pfeifer J,Heitto A,Kontkanen J,Dada L,Kürten A,Yli-Juuti T,Manninen HE,Amanatidis S,Amorim A,Baalbaki R,Baccarini A,Bell DM,Bertozzi B,Bräkling S,Brilke S,Murillo LC,Chiu R,

更新日期：2020-05-01 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00