Abstract:
:A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-dependent glucose transport. Insulin promotes glucose transport in these tissues by stimulating movement of the glucose transporter from an intracellular location to the plasma membrane. Recent studies, however, suggest that an additional effect of insulin in these tissues may be the facilitation of glucose transport, presumably across capillary endothelium. This hypothesis is based on the localization of the IRGT in endothelial cells specific to muscle and adipose tissue. We report here, however, on morphological and biochemical studies using several different IRGT-specific antibodies in which we could not reproduce these results.
journal_name
Naturejournal_title
Natureauthors
Slot JW,Moxley R,Geuze HJ,James DEdoi
10.1038/346369a0subject
Has Abstractpub_date
1990-07-26 00:00:00pages
369-71issue
6282eissn
0028-0836issn
1476-4687journal_volume
346pub_type
杂志文章相关文献
NATURE文献大全abstract::A chimaeric gene, consisting of the 5'-flanking region of a member of the Pisum sativum gene family encoding ribulose 1,5-bisphosphate carboxylase linked to the coding region of a bacterial chloramphenicol acetyltransferase gene, has been introduced into the genome of the plant Nicotiana tabacum using a Ti plasmid of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310115a0
更新日期:1984-07-12 00:00:00
abstract::The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282623a0
更新日期:1979-12-06 00:00:00
abstract::This is an exciting time for scientific discovery that aims to reduce the frequency and impact of neurological, mental health and substance-use disorders. As it became increasingly clear that low- and middle-income countries have a disproportionate share of these disorders, and that many of the problems are best addre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16028
更新日期:2015-11-19 00:00:00
abstract::The genetic relationships of human populations have been studied by comparing gene frequency data for protein and blood-group loci of different populations. DNA analysis now promises to be more informative since not only do the DNA coding sequences have more variation than their corresponding proteins but, in addition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/319491a0
更新日期:1986-02-06 00:00:00
abstract::The rheological properties of rock salt are of fundamental importance in predicting the long-term evolution of salt-based radioactive waste repositories and strategic storage caverns, and in modelling the formation of salt diapirs and associated oil traps1,2. The short-term, high-stress rheology of rock salt is well k...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324554a0
更新日期:1986-12-11 00:00:00
abstract::Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22039
更新日期:2017-04-26 00:00:00
abstract::When we reach towards an object that suddenly appears in our peripheral visual field, not only does our arm extend towards the object, but our eyes, head and body also move in such a way that the image of the object falls on the fovea. Popular models of how reaching movements are programmed have argued that while the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320748a0
更新日期:1986-04-24 00:00:00
abstract::Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13729
更新日期:2014-10-02 00:00:00
abstract::Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the ess...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11814
更新日期:2013-02-14 00:00:00
abstract::The Nuffield Council on Bioethics suggests that introgression of genetic material into related species in centres of crop biodiversity is an insufficient justification to bar the use of genetically modified crops in the developing world. They consider that a precautionary approach to forgo the possible benefits invoke...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03048
更新日期:2004-11-11 00:00:00
abstract::Jupiter's ring system has previously been described as being composed of a 'bright' narrow ring and an interior, vertically-extended halo. The one image which reveals this morphology most clearly is Voyager 2's parting shot of the Jupiter system, a wide-angle (WA) view of the ring ansa in forward-scattered light (FDS...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316526a0
更新日期:1985-08-08 00:00:00
abstract::Bcl-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma. Bcl-2 has the unique oncogenic role of extending cell survival by inhibiting a variety of apoptotic deaths. An emerging family of Bcl-2-related proteins share two highly conserved regions referred to here as Bcl-2 homology 1 and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369321a0
更新日期:1994-05-26 00:00:00
abstract::DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356168a0
更新日期:1992-03-12 00:00:00
abstract::Crystal structures of insulin have been determined in various distinct forms, the relevance of which to receptor recognition has long been the subject of speculation. Recently the crystal structure of an inactive insulin analogue has been determined and, surprisingly, found to have a conformation identical to native i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/354238a0
更新日期:1991-11-21 00:00:00
abstract::The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic peptide-major histocompatibility complex (pMHC) molecules on other cells. If productive, these interactions promote the formation of an immu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08746
更新日期:2010-02-18 00:00:00
abstract::Emerging infectious diseases present a formidable challenge to the conservation of native species in the twenty-first century. Diseases caused by introduced pathogens have had large impacts on species abundances, including the American chestnut, Hawaiian bird species and many amphibians. Changes in host population siz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05829
更新日期:2007-06-07 00:00:00
abstract::Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature17038
更新日期:2016-01-21 00:00:00
abstract::Several distinct cell lineages are established during mouse embryogenesis. The trophectoderm and primitive endoderm give rise to extraembryonic structures alone, while the primitive ectoderm becomes the fetus proper. Recent studies suggest that the levels of DNA modification are lower in inactive X chromosomes from ex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307284a0
更新日期:1984-01-19 00:00:00
abstract::The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif, VISA and IPS-1) during a viral infection. MAVS activation leads to the rapid production of antiviral cytokines, including type 1 interfer...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06501
更新日期:2008-01-31 00:00:00
abstract::Ultrafast time-resolved optical spectroscopy has revealed new classes of physical, chemical and biological reactions, in which directed, deterministic motions of atoms have a key role. This contrasts with the random, diffusive motion of atoms across activation barriers that typically determines kinetic rates on slower...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35065045
更新日期:2001-03-01 00:00:00
abstract::In contrast to microRNAs and Piwi-associated RNAs, short interfering RNAs (siRNAs) are seemingly dispensable for host-directed gene regulation in Drosophila. This notion is based on the fact that mutants lacking the core siRNA-generating enzyme Dicer-2 or the predominant siRNA effector Argonaute 2 are viable, fertile ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07015
更新日期:2008-06-05 00:00:00
abstract::The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism conv...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287396a0
更新日期:1980-10-02 00:00:00
abstract::It has long been thought that mature oligodendrocytes in the adult mammalian central nervous system (CNS) are post-mitotic and are unable to proliferate in response to injury. The implications of this have been profound, because it has been suggested that this failure of oligodendrocytes to undergo mitosis is perhaps ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308274a0
更新日期:1984-03-15 00:00:00
abstract::Arbuscular mycorrhizal (AM) fungi (Glomeromycota) reproduce asexually, are multinucleate, and have high genetic variation within single cells. Pawlowska and Taylor find that genetic variation within AM fungal cells is not lost as a result of segregation, and they interpret this as evidence that the variation is presen...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature03294
更新日期:2005-01-13 00:00:00
abstract::H-2 class I antigens appear to direct the recognition of virus-infected and neoplastic transformed cells by cytotoxic T lymphocytes (CTLs). Here, to identify the regions of class I antigens involved in CTL recognition, four hybrid class I genes were constructed in which exons were exchanged between the H-2Kb and H-2Db...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309279a0
更新日期:1984-05-17 00:00:00
abstract::Segmentation of the vertebrate hindbrain into rhombomeres is important for the anterior-posterior arrangement of cranial motor nuclei and efferent nerves. Underlying this reiterated organization, Hox genes display segmentally restricted domains of expression, such as expression of Hoxb-1 (refs 5, 6) in rhombomere 4 (r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384630a0
更新日期:1996-12-19 00:00:00
abstract::RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site). The nuclease activity is then attenuated and RecBCD loads Re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02988
更新日期:2004-11-11 00:00:00
abstract::A long-standing problem in managing the behaviour of a collection of solid grains concerns the nature of the grain packing, a property that is typically controlled by how the grains are poured or shaken. Here we show that a systematic and controllable increase in granular packing can be induced by simply raising and t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/442257a
更新日期:2006-07-20 00:00:00
abstract::Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347765a0
更新日期:1990-10-25 00:00:00
abstract::Histamine secretion from mast cells may be inhibited by elevated intracellular levels of cyclic AMP and by several anti-allergic drugs. These compounds are claimed to act directly on the calcium-gating mechanism activated by the anaphylactic reaction, preventing influx of Ca2+ from the external environment and so bloc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289186a0
更新日期:1981-01-15 00:00:00