Environmental biosafety and transgenic potato in a centre of diversity for this crop.

abstract：:The innate immune defence of multicellular organisms against microbial pathogens requires cellular collaboration. Information exchange allowing immune cells to collaborate is generally attributed to soluble protein factors secreted by pathogen-sensing cells. Cytokines, such as type I interferons (IFNs), serve to alert...

journal_title：Nature

authors： Ablasser A,Schmid-Burgk JL,Hemmerling I,Horvath GL,Schmidt T,Latz E,Hornung V

更新日期：2013-11-28 00:00:00

abstract：:Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase, EC 1.14.16.1). PKU is a common inborn error of amino-acid metabolism in caucasian populations and approximately 1 in 50 individuals are carriers of a P...

journal_title：Nature

authors： DiLella AG,Marvit J,Brayton K,Woo SL

更新日期：1987-05-28 00:00:00

abstract：:The Earth's convecting upper mantle can be viewed as comprising three main reservoirs, beneath the Pacific, Atlantic and Indian oceans. Because of the uneven global distribution and migration of ridges and subduction zones, the surface area of the Pacific reservoir is at present contracting at about 0.6 km2 x y(r-1), ...

journal_title：Nature

authors： Pearce JA,Leat PT,Barker PF,Millar IL

更新日期：2001-03-22 00:00:00

abstract：:Fibres in the mammalian optic nerve are generally thought to be organised retinotopically. Recording electrophysiologically from the cat optic nerve, we found little evidence to support this notion, which led us to investigate the problem by anatomical methods. We made a localised injection of horseradish peroxidase i...

journal_title：Nature

authors： Horton JC,Greenwood MM,Hubel DH

更新日期：1979-12-13 00:00:00

abstract：:The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution. The structure shows a homo-pentameric protein with a barrel-stave architecture that defines an ion-conduction pore located on the f...

journal_title：Nature

authors： Hilf RJ,Dutzler R

更新日期：2009-01-01 00:00:00

abstract：:Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin1-3. Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cycl...

journal_title：Nature

authors： Hellmuth S,Gómez-H L,Pendás AM,Stemmann O

更新日期：2020-04-01 00:00:00

abstract：:Nuclear import of the NF-AT transcription factors during T-cell activation requires the calcium-activated phosphatase calcineurin, which unmasks nuclear-location signals on NF-AT. We show here that the nuclear import of NF-ATs is not sufficient to activate NF-AT target genes, as NF-ATs are subject to a futile cycling ...

journal_title：Nature

authors： Zhu J,McKeon F

更新日期：1999-03-18 00:00:00

abstract：:A large number of cis-regulatory sequences have been annotated in the human genome, but defining their target genes remains a challenge. One strategy is to identify the long-range looping interactions at these elements with the use of chromosome conformation capture (3C)-based techniques. However, previous studies lac...

journal_title：Nature

authors： Jin F,Li Y,Dixon JR,Selvaraj S,Ye Z,Lee AY,Yen CA,Schmitt AD,Espinoza CA,Ren B

更新日期：2013-11-14 00:00:00

abstract：:Transforming viral proteins such as E1A force cells through the restriction point of the cell cycle into S phase by forming complexes with two cellular proteins: the retinoblastoma protein (Rb), a transcriptional co-repressor, and CBP/p300, a transcriptional co-activator. These two proteins locally influence chromatin...

journal_title：Nature

authors： Ait-Si-Ali S,Ramirez S,Barre FX,Dkhissi F,Magnaghi-Jaulin L,Girault JA,Robin P,Knibiehler M,Pritchard LL,Ducommun B,Trouche D,Harel-Bellan A

更新日期：1998-11-12 00:00:00

abstract：:The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of major vertebrate lineages such as mammals, including humans. Birds are the most speciose land verteb...

journal_title：Nature

authors： Bhullar BA,Marugán-Lobón J,Racimo F,Bever GS,Rowe TB,Norell MA,Abzhanov A

更新日期：2012-07-12 00:00:00

abstract：:Group I and II introns are mobile elements that propagate by insertion into different genes. Some introns of both types self-splice in vitro by transesterification reactions catalysed by the intron RNA. These transesterifications are reversible, and it has been suggested that reverse splicing followed by reverse trans...

journal_title：Nature

authors： Mohr G,Lambowitz AM

更新日期：1991-11-14 00:00:00

abstract：:ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...

journal_title：Nature

authors： Fan J,Ye J,Kamphorst JJ,Shlomi T,Thompson CB,Rabinowitz JD

更新日期：2014-06-12 00:00:00

abstract：:The origin of cooperation is a central challenge to our understanding of evolution. The fact that microbial interactions can be manipulated in ways that animal interactions cannot has led to a growing interest in microbial models of cooperation and competition. For the budding yeast Saccharomyces cerevisiae to grow on...

journal_title：Nature

authors： Gore J,Youk H,van Oudenaarden A

更新日期：2009-05-14 00:00:00

abstract：:Diapycnal mixing (across density surfaces) is an important process in the global ocean overturning circulation. Mixing in the interior of most of the ocean, however, is thought to have a magnitude just one-tenth of that required to close the global circulation by the downward mixing of less dense waters. Some of this ...

journal_title：Nature

authors： Watson AJ,Ledwell JR,Messias MJ,King BA,Mackay N,Meredith MP,Mills B,Naveira Garabato AC

更新日期：2013-09-19 00:00:00

abstract：:Human cooperation in social dilemmas challenges researchers from various disciplines. Here we combine advances in experimental economics and evolutionary biology that separately have shown that costly punishment and reputation formation, respectively, induce cooperation in social dilemmas. The mechanisms of punishment...

journal_title：Nature

authors： Rockenbach B,Milinski M

更新日期：2006-12-07 00:00:00

abstract：:The determination of molecular masses from barometric sedimentation profiles, a main topic in ultracentrifugal analysis, is thought to be quantitatively correct for non-interacting particles. Whereas this expectation is justified for uncharged colloids or macromolecules at low volume fractions, early ultracentrifugati...

journal_title：Nature

authors： Raşa M,Philipse AP

更新日期：2004-06-24 00:00:00

abstract：:Seafloor spreading is largely unobserved because 98 per cent of the global mid-ocean-ridge system is below the ocean surface. Our understanding of the dynamic processes that control seafloor spreading is thus inferred largely from geophysical observations of spreading events on land at Afar in East Africa and Iceland....

journal_title：Nature

authors： Tan YJ,Tolstoy M,Waldhauser F,Wilcock WS

更新日期：2016-12-08 00:00:00

abstract：:Xenoturbellida and Acoelomorpha are marine worms with contentious ancestry. Both were originally associated with the flatworms (Platyhelminthes), but molecular data have revised their phylogenetic positions, generally linking Xenoturbellida to the deuterostomes and positioning the Acoelomorpha as the most basally bran...

journal_title：Nature

authors： Philippe H,Brinkmann H,Copley RR,Moroz LL,Nakano H,Poustka AJ,Wallberg A,Peterson KJ,Telford MJ

更新日期：2011-02-10 00:00:00

abstract：:Interleukin-2 (IL-2) is a regulatory peptide important for the growth and differentiation of antigen-specific T lymphocytes and large granular lymphocytes. Interaction of IL-2 with its specific receptor results in the promotion of S-phase progression as well as, in certain circumstances, the production and release of ...

journal_title：Nature

authors： Farrar WL,Anderson WB

更新日期：1985-05-16 00:00:00

abstract：:It is possible to infer aspects of an organism's lifestyle from its gene content. Can the reverse also be done? Here we consider this issue by modelling evolution of the reduced genomes of endosymbiotic bacteria. The diversity of gene content in these bacteria may reflect both variation in selective forces and conting...

journal_title：Nature

authors： Pál C,Papp B,Lercher MJ,Csermely P,Oliver SG,Hurst LD

更新日期：2006-03-30 00:00:00

abstract：:An inductor, one of the most fundamental circuit elements in modern electronic devices, generates a voltage proportional to the time derivative of the input current1. Conventional inductors typically consist of a helical coil and induce a voltage as a counteraction to time-varying magnetic flux penetrating the coil, f...

journal_title：Nature

authors： Yokouchi T,Kagawa F,Hirschberger M,Otani Y,Nagaosa N,Tokura Y

更新日期：2020-10-01 00:00:00

abstract：:There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...

journal_title：Nature

authors： Bozovic I,Logvenov G,Verhoeven MA,Caputo P,Goldobin E,Geballe TH

更新日期：2003-04-24 00:00:00

abstract：:Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of ...

journal_title：Nature

authors： Wood JG,Rogina B,Lavu S,Howitz K,Helfand SL,Tatar M,Sinclair D

更新日期：2004-08-05 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that des...

journal_title：Nature

authors： Janney A,Powrie F,Mann EH

更新日期：2020-09-01 00:00:00

abstract：:Granular materials and ordinary fluids react differently to shear stresses. Rather than deforming uniformly, materials such as dry sand or cohesionless powders develop shear bands--narrow zones of large relative particle motion, with essentially rigid adjacent regions. Because shear bands mark areas of flow, material ...

journal_title：Nature

authors： Mueth DM,Debregeas GF,Karczmar GS,Eng PJ,Nagel SR,Jaeger HM

更新日期：2000-07-27 00:00:00

abstract：:The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control...

journal_title：Nature

authors： Sawamiphak S,Seidel S,Essmann CL,Wilkinson GA,Pitulescu ME,Acker T,Acker-Palmer A

更新日期：2010-05-27 00:00:00

abstract：:Explaining altruistic cooperation is one of the greatest challenges for evolutionary biology. One solution to this problem is if costly cooperative behaviours are directed towards relatives. This idea of kin selection has been hugely influential and applied widely from microorganisms to vertebrates. However, a problem...

journal_title：Nature

authors： Griffin AS,West SA,Buckling A

更新日期：2004-08-26 00:00:00

abstract：:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...

journal_title：Nature

authors： Steinman RM,Banchereau J

更新日期：2007-09-27 00:00:00

abstract：:In the few species of birds in which males form display partnerships to attract females, one male secures most or all of the copulations. This leads to the question of why subordinate males help in the absence of observable reproductive benefits. Hamilton's concept of kin selection, whereby individuals can benefit ind...

journal_title：Nature

authors： Krakauer AH

更新日期：2005-03-03 00:00:00

abstract：:The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian peninsula in the west. This range encompassed tropical forest, savannah and Mediterranean habitats, but has hitherto not been demonstrated beyond 45 degrees N. Until ...

journal_title：Nature

authors： Parfitt SA,Ashton NM,Lewis SG,Abel RL,Coope GR,Field MH,Gale R,Hoare PG,Larkin NR,Lewis MD,Karloukovski V,Maher BA,Peglar SM,Preece RC,Whittaker JE,Stringer CB

更新日期：2010-07-08 00:00:00