Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Abstract:

:Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.

journal_name

Nature

journal_title

Nature

authors

Wood JG,Rogina B,Lavu S,Howitz K,Helfand SL,Tatar M,Sinclair D

doi

10.1038/nature02789

keywords:

subject

Has Abstract

pub_date

2004-08-05 00:00:00

pages

686-9

issue

7000

eissn

0028-0836

issn

1476-4687

pii

nature02789

journal_volume

430

pub_type

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