Abstract:
:Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.
journal_name
Naturejournal_title
Natureauthors
Wood JG,Rogina B,Lavu S,Howitz K,Helfand SL,Tatar M,Sinclair Ddoi
10.1038/nature02789keywords:
subject
Has Abstractpub_date
2004-08-05 00:00:00pages
686-9issue
7000eissn
0028-0836issn
1476-4687pii
nature02789journal_volume
430pub_type
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