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Long-range correlations in nucleotide sequences.

Abstract：

:DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term a 'DNA walk'. We then use the mapping to provide a quantitative measure of the correlation between nucleotides over long distances along the DNA chain. Thus we uncover in the nucleotide sequence a remarkably long-range power law correlation that implies a new scale-invariant property of DNA. We find such long-range correlations in intron-containing genes and in nontranscribed regulatory DNA sequences, but not in complementary DNA sequences or intron-less genes.

journal_name

Nature

journal_title

Nature

authors

Peng CK,Buldyrev SV,Goldberger AL,Havlin S,Sciortino F,Simons M,Stanley HE

doi

10.1038/356168a0

keywords:

subject

Has Abstract

pub_date

1992-03-12 00:00:00

pages

168-70

issue

6365

eissn

0028-0836

issn

1476-4687

journal_volume

356

pub_type

杂志文章

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