Abstract:
:Over the last twenty years, there has been rapid growth of a new approach to understanding the evolution of organismic form. This evolutionary developmental biology, or 'evo-devo', is focused on the developmental genetic machinery that lies behind embryological phenotypes, which were all that could be studied in the past. Are there any general concepts emerging from this new approach, and if so, how do they impact on the conceptual structure of traditional evolutionary biology? In providing answers to these questions, this review assesses whether evo-devo is merely filling in some missing details, or whether it will cause a large-scale change in our thinking about the evolutionary process.
journal_name
Naturejournal_title
Natureauthors
Arthur Wdoi
10.1038/415757akeywords:
subject
Has Abstractpub_date
2002-02-14 00:00:00pages
757-64issue
6873eissn
0028-0836issn
1476-4687pii
415757ajournal_volume
415pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::In contrast to protein-coding sequences, the significance of variation in non-coding DNA in human disease has been minimally explored. A great number of recent genome-wide association studies suggest that non-coding variation is a significant risk factor for common disorders, but the mechanisms by which this variation...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature08451
更新日期:2009-09-10 00:00:00
abstract::Plants can have positive effects on each other. For example, the accumulation of nutrients, provision of shade, amelioration of disturbance, or protection from herbivores by some species can enhance the performance of neighbouring species. Thus the notion that the distributions and abundances of plant species are inde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00812
更新日期:2002-06-20 00:00:00
abstract::Caste differentiation and division of labour are the hallmarks of insect societies and at the root of their ecological success. Kin selection predicts that caste determination should result from environmentally induced differences in gene expression, a prediction largely supported by empirical data. However, two excep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01744
更新日期:2003-07-17 00:00:00
abstract::Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350473a0
更新日期:1991-04-11 00:00:00
abstract::Materials are said to show a shape-memory effect if they can be deformed and fixed into a temporary shape, and recover their original, permanent shape only on exposure to an external stimulus. Shape-memory polymers have received increasing attention because of their scientific and technological significance. In princi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03496
更新日期:2005-04-14 00:00:00
abstract::Observations from Earth-orbiting satellites have been a key component in monitoring climate change for the past two decades. This has become possible with the availability of air temperatures from the Microwave Sounding Unit (MSU) since 1979, sea surface temperatures from the Advanced Very High Resolution Radiometer (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35000184
更新日期:2000-01-27 00:00:00
abstract::Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359653a0
更新日期:1992-10-15 00:00:00
abstract::Only about 1% of human XO conceptuses survive to birth and these usually have the characteristics of Turner's syndrome, with a complex and variable phenotype including short stature, gonadal dysgenesis and anatomical defects. Both the embryonic lethality and Turner's syndrome are thought to be due to monosomy for a ge...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351406a0
更新日期:1991-05-30 00:00:00
abstract::TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors. It alters the affinity of the receptors for EGF without changing the total...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279387a0
更新日期:1979-05-31 00:00:00
abstract::Integral membrane proteins are encoded by approximately 25% of all protein-coding genes1. In eukaryotes, the majority of membrane proteins are inserted, modified and folded at the endoplasmic reticulum (ER)2. Research over the past several decades has determined how membrane proteins are targeted to the ER and how ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2624-y
更新日期:2020-08-01 00:00:00
abstract::Whereas short-term memory lasts from minutes to hours, long-term memory (LTM) can last for days or even an entire lifetime. LTM generally forms after spaced repeated training sessions and involves the regulation of gene expression, thereby implicating transcription factors in the initial steps of LTM establishment. Ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02726
更新日期:2004-07-22 00:00:00
abstract::Predation can be intense, creating strong direct and indirect effects throughout food webs. In addition, ecologists increasingly recognize that fluxes of organisms across ecosystem boundaries can have major consequences for community dynamics. Species with complex life histories often shift habitats during their life ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03962
更新日期:2005-10-06 00:00:00
abstract::Individuals with congenital or acquired prolongation of the QT interval, or long QT syndrome (LQTS), are at risk of life-threatening ventricular arrhythmia. LQTS is commonly genetic in origin but can also be caused or exacerbated by environmental factors. A missense mutation in the L-type calcium channel Ca(V)1.2 lead...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09855
更新日期:2011-03-10 00:00:00
abstract::Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352431a0
更新日期:1991-08-01 00:00:00
abstract::The mechanism of action of antisteroids is not understood and explanations of their antagonistic activity have been sought at all levels of hormone action. It has been proposed that antisteroids, after binding to receptor, trap it into a non-activated (non DNA-binding) form possibly through interaction with a heat-sho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/336695a0
更新日期:1988-12-15 00:00:00
abstract::The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06423
更新日期:2007-12-13 00:00:00
abstract::The modern giant sperm whale Physeter macrocephalus, one of the largest known predators, preys upon cephalopods at great depths. Lacking a functional upper dentition, it relies on suction for catching its prey; in contrast, several smaller Miocene sperm whales (Physeteroidea) have been interpreted as raptorial (versus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09067
更新日期:2010-07-01 00:00:00
abstract::Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363179a0
更新日期:1993-05-13 00:00:00
abstract::Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16959
更新日期:2016-02-18 00:00:00
abstract::Observations show that the seismic normal modes of the Earth at frequencies near 10 mHz are excited at a nearly constant level in the absence of large earthquakes. This background level of excitation has been called the 'hum' of the Earth, and is equivalent to the maximum excitation from a magnitude 5.75 earthquake. I...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05536
更新日期:2007-02-15 00:00:00
abstract::Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is derived from the beta-amyloid precursor protein (beta-APP) which is expressed in several different isoforms. The two most prevalent b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352239a0
更新日期:1991-07-18 00:00:00
abstract::It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313678a0
更新日期:1985-02-21 00:00:00
abstract::Recent studies have shown that developing nerve fibres grow directly to their targets and are guided by specific cues, but the nature of these cues and the mechanism of guidance remain unknown. The growth of sympathetic axons towards an artificial source of nerve growth factor (NGF) in vivo and of sensory neurites up ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/306786a0
更新日期:1983-12-22 00:00:00
abstract::Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion anal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature751
更新日期:2002-05-30 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,社论
doi:10.1038/d41586-019-00483-5
更新日期:2019-02-01 00:00:00
abstract::Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35089076
更新日期:2001-08-16 00:00:00
abstract::The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16949
更新日期:2016-02-11 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord. Its cause is unknown and it is uniformly fatal, typically within five years. About 10% of cases are inherited as an autosomal dominant trait, with high penetrance after the sixth decade. In most in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362059a0
更新日期:1993-03-04 00:00:00
abstract::The product of the bacteriophage Mu gene mom modifies adenine residues of DNA within the consensus sequence CGAGCNPy, providing protection against various restriction endonucleases (ref. 1 and D. Kamp, personal communication cited in ref. 2). The mom gene is only expressed during lytic development of the phage. It is ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301344a0
更新日期:1983-01-27 00:00:00
abstract::Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible reactions in the target sequence, such as photocrosslinking or cleavag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344358a0
更新日期:1990-03-22 00:00:00