Production of soluble MHC class II proteins with covalently bound single peptides.

abstract：:Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...

journal_title：Nature

authors： Trainor CD,Evans T,Felsenfeld G,Boguski MS

更新日期：1990-01-04 00:00:00

abstract：:The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...

journal_title：Nature

authors： Rossier J,Audigier Y,Ling N,Cros J,Udenfriend S

更新日期：1980-11-06 00:00:00

abstract：:The benzodiazepines are a class of drugs used to alleviate anxiety. As such they constitute one of the most commonly prescribed compounds, due in part to their efficacy and safety. The physiological effect of these drugs is probably through interactions with a low affinity benzodiazepine binding site and two (types 1 ...

journal_title：Nature

authors： Barr GA,Lithgow T

更新日期：1983-03-31 00:00:00

abstract：:The quantum-level interplay between geometry, topology and correlation is at the forefront of fundamental physics1-15. Kagome magnets are predicted to support intrinsic Chern quantum phases owing to their unusual lattice geometry and breaking of time-reversal symmetry14,15. However, quantum materials hosting ideal spi...

journal_title：Nature

authors： Yin JX,Ma W,Cochran TA,Xu X,Zhang SS,Tien HJ,Shumiya N,Cheng G,Jiang K,Lian B,Song Z,Chang G,Belopolski I,Multer D,Litskevich M,Cheng ZJ,Yang XP,Swidler B,Zhou H,Lin H,Neupert T,Wang Z,Yao N,Chang TR,Jia S

更新日期：2020-07-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-12-01 00:00:00

abstract：:As the fraction of electricity generation from intermittent renewable sources--such as solar or wind--grows, the ability to store large amounts of electrical energy is of increasing importance. Solid-electrode batteries maintain discharge at peak power for far too short a time to fully regulate wind or solar power out...

journal_title：Nature

authors： Huskinson B,Marshak MP,Suh C,Er S,Gerhardt MR,Galvin CJ,Chen X,Aspuru-Guzik A,Gordon RG,Aziz MJ

更新日期：2014-01-09 00:00:00

abstract：:Butterflies rely extensively on colour vision to adapt to the natural world. Most species express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eyes), which are distributed stochastically across the retina. The retinas of Drosophila melanogaster use just two main types, in whic...

journal_title：Nature

authors： Perry M,Kinoshita M,Saldi G,Huo L,Arikawa K,Desplan C

更新日期：2016-07-14 00:00:00

abstract：:Understanding the pathogenesis of neuropsychiatric disorders is a substantial challenge for neurobiologists. It has long been hoped that identifying alleles that confer increased risk of such disorders would provide clues for neurobiological investigation. But this quest has been stymied by a lack of validated biologi...

journal_title：Nature

authors： Hyman SE

更新日期：2008-10-16 00:00:00

abstract：:It is generally accepted that the oscillatory beating characteristic of sperm flagella is the result of an ATP-induced sliding between the doublet microtubules of the flagellar axoneme, with these longitudinal forces being converted into a lateral bending moment by resistive components of the structure that limit the ...

journal_title：Nature

authors： Gibbons IR,Shingyoji C,Murakami A,Takahashi K

更新日期：1987-01-22 00:00:00

abstract：:Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in normal bone homeostasis (called 'bone remodelling') but also in the pathogenesis of bone destructive disorders such as rheumatoid arthritis and osteoporosis. A major focus of research in the field ha...

journal_title：Nature

authors： Ishii M,Egen JG,Klauschen F,Meier-Schellersheim M,Saeki Y,Vacher J,Proia RL,Germain RN

更新日期：2009-03-26 00:00:00

abstract：:Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...

journal_title：Nature

authors： Svoboda K,Schmidt CF,Schnapp BJ,Block SM

更新日期：1993-10-21 00:00:00

abstract：:Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell...

journal_title：Nature

authors： Rajewsky N,Almouzni G,Gorski SA,Aerts S,Amit I,Bertero MG,Bock C,Bredenoord AL,Cavalli G,Chiocca S,Clevers H,De Strooper B,Eggert A,Ellenberg J,Fernández XM,Figlerowicz M,Gasser SM,Hubner N,Kjems J,Knoblich JA,Kra

更新日期：2020-11-01 00:00:00

abstract：:Explaining altruistic cooperation is one of the greatest challenges for evolutionary biology. One solution to this problem is if costly cooperative behaviours are directed towards relatives. This idea of kin selection has been hugely influential and applied widely from microorganisms to vertebrates. However, a problem...

journal_title：Nature

authors： Griffin AS,West SA,Buckling A

更新日期：2004-08-26 00:00:00

abstract：:Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and ep...

journal_title：Nature

authors： Hoshino A,Costa-Silva B,Shen TL,Rodrigues G,Hashimoto A,Tesic Mark M,Molina H,Kohsaka S,Di Giannatale A,Ceder S,Singh S,Williams C,Soplop N,Uryu K,Pharmer L,King T,Bojmar L,Davies AE,Ararso Y,Zhang T,Zhang H,Her

更新日期：2015-11-19 00:00:00

abstract：:In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 Å resolution, and with a non-nucleotide antago...

journal_title：Nature

authors： Zhang D,Gao ZG,Zhang K,Kiselev E,Crane S,Wang J,Paoletta S,Yi C,Ma L,Zhang W,Han GW,Liu H,Cherezov V,Katritch V,Jiang H,Stevens RC,Jacobson KA,Zhao Q,Wu B

更新日期：2015-04-16 00:00:00

abstract：:The Kyoto Protocol permits countries to meet part of their emission reduction obligations by cutting back on gases other than CO2 (ref. 1). This approach requires a definition of trade-offs among the radiatively active gases. The Intergovernmental Panel on Climate Change has suggested global warming potentials for thi...

journal_title：Nature

authors： Manne AS,Richels RG

更新日期：2001-04-05 00:00:00

abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...

journal_title：Nature

authors： Dustin ML,Springer TA

更新日期：1989-10-19 00:00:00

abstract：:Nearly all protocols requiring shared quantum information--such as quantum teleportation or key distribution--rely on entanglement between distant parties. However, entanglement is difficult to characterize experimentally. All existing techniques for doing so, including entanglement witnesses or Bell inequalities, dis...

journal_title：Nature

authors： Walborn SP,Souto Ribeiro PH,Davidovich L,Mintert F,Buchleitner A

更新日期：2006-04-20 00:00:00

abstract：:General alarm about genetics continues, fanned by the expectation that what may one day be possible will be a reality tomorrow. Moderation is the most urgent need, but understanding would also help. ...

journal_title：Nature

authors：

更新日期：1994-01-13 00:00:00

abstract：:Self-propagating beta-sheet-rich protein aggregates are implicated in a wide range of protein-misfolding phenomena, including amyloid diseases and prion-based inheritance. Two properties have emerged as common features of amyloids. Amyloid formation is ubiquitous: many unrelated proteins form such aggregates and even ...

journal_title：Nature

authors： Chien P,DePace AH,Collins SR,Weissman JS

更新日期：2003-08-21 00:00:00

abstract：:A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...

journal_title：Nature

authors： Kanamori H,Press F

更新日期：1970-04-25 00:00:00

abstract：:Topological insulators-materials that are insulating in the bulk but allow electrons to flow on their surface-are striking examples of materials in which topological invariants are manifested in robustness against perturbations such as defects and disorder1. Their most prominent feature is the emergence of edge states...

journal_title：Nature

authors： Klembt S,Harder TH,Egorov OA,Winkler K,Ge R,Bandres MA,Emmerling M,Worschech L,Liew TCH,Segev M,Schneider C,Höfling S

更新日期：2018-10-01 00:00:00

abstract：:Many homeobox genes are clustered in a linear array along a chromosome, reflecting their ordered expression along the anterior-posterior axis of the embryo. Expression patterns as well as grafting, ectopic expression and loss-of-function experiments suggest that the Hox genes encode a combinatorial system of positiona...

journal_title：Nature

authors： Roberts CW,Shutter JR,Korsmeyer SJ

更新日期：1994-04-21 00:00:00

abstract：:Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see ...

journal_title：Nature

authors： Thilker DA,Donovan J,Schiminovich D,Bianchi L,Boissier S,de Paz AG,Madore BF,Martin DC,Seibert M

更新日期：2009-02-19 00:00:00

abstract：:The product of the bacteriophage Mu gene mom modifies adenine residues of DNA within the consensus sequence CGAGCNPy, providing protection against various restriction endonucleases (ref. 1 and D. Kamp, personal communication cited in ref. 2). The mom gene is only expressed during lytic development of the phage. It is ...

journal_title：Nature

authors： Plasterk RH,Vrieling H,Van de Putte P

更新日期：1983-01-27 00:00:00

abstract：:Exploiters (parasites and predators) are thought to play a significant role in diversification, and ultimately speciation, of their hosts or prey. Exploiters may drive sympatric (within-population) diversification if there are a variety of exploiter-resistance strategies or fitness costs associated with exploiter resi...

journal_title：Nature

authors： Buckling A,Rainey PB

更新日期：2002-12-05 00:00:00

abstract：:Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...

journal_title：Nature

authors： Lovley DR,Woodward JC,Chapelle FH

更新日期：1994-07-14 00:00:00

abstract：:The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders1-4. Here we show that the assembly of the viral community in neonates takes place in distinct steps. Fluorescent staining of virus-like particles purified from...

journal_title：Nature

authors： Liang G,Zhao C,Zhang H,Mattei L,Sherrill-Mix S,Bittinger K,Kessler LR,Wu GD,Baldassano RN,DeRusso P,Ford E,Elovitz MA,Kelly MS,Patel MZ,Mazhani T,Gerber JS,Kelly A,Zemel BS,Bushman FD

更新日期：2020-05-01 00:00:00

abstract：:The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Activation of adenylyl cyclases results in the production of cyclic AMP and activation of c...

journal_title：Nature

authors： Liu M,Simon MI

更新日期：1996-07-04 00:00:00

abstract：:It has been proposed that the trans-sarcolemmal influx of Ca2+ occurring during the plateau of the mammalian cardiac action potentials is insufficient in itself to activate the myofilaments, but can trigger a release of Ca2+ from the sarcoplasmic reticulum (SR) which is sufficient for activation. The demonstration of ...

journal_title：Nature

authors： Fabiato A,Fabiato F

更新日期：1979-09-13 00:00:00