An alternative approach to establishing trade-offs among greenhouse gases.

abstract：:Rates of atmospheric deposition of biologically active nitrogen (N) are two to seven times the pre-industrial rates in many developed nations because of combustion of fossil fuels and agricultural fertilization. They are expected to increase similarly over the next 50 years in industrializing nations of Asia and South...

journal_title：Nature

authors： Clark CM,Tilman D

更新日期：2008-02-07 00:00:00

abstract：:A product encoded at the claret locus in Drosophila is needed for normal chromosome segregation in meiosis in females and in early mitotic divisions of the embryo. The predicted amino-acid sequence of the segregation protein was shown recently to be strikingly similar to Drosophila kinesin heavy chain. We have express...

journal_title：Nature

authors： Walker RA,Salmon ED,Endow SA

更新日期：1990-10-25 00:00:00

abstract：:The carotid body type I cell contains amines and has features, both morphological and cytochemical, which indicate that it may also produce a peptide. Many regulatory peptides are now known to be present in both central and peripheral tissues. In the periphery these neuropeptides occur in both classical endocrine (APU...

journal_title：Nature

authors： Wharton J,Polak JM,Pearse AG,McGregor GP,Bryant MG,Bloom SR,Emson PC,Bisgard GE,Will JA

更新日期：1980-03-20 00:00:00

abstract：:Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...

journal_title：Nature

authors： Svoboda K,Schmidt CF,Schnapp BJ,Block SM

更新日期：1993-10-21 00:00:00

abstract：:Surgical, pharmacological and genetic lesion studies have revealed distinct anatomical sites involved with different forms of learning. Studies of patients with localized brain damage and work in rodent model systems, for example, have shown that the hippocampal formation participates in acquisition of declarative tas...

journal_title：Nature

authors： Dubnau J,Grady L,Kitamoto T,Tully T

更新日期：2001-05-24 00:00:00

abstract：:Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates...

journal_title：Nature

authors： Glotzer M,Murray AW,Kirschner MW

更新日期：1991-01-10 00:00:00

abstract：:Large seasonal and hemispheric asymmetries in the martian climate system are generally ascribed to variations in solar heating associated with orbital eccentricity. As the orbital elements slowly change (over a period of >104 years), characteristics of the climate such as dustiness and the vigour of atmospheric circul...

journal_title：Nature

authors： Richardson MI,Wilson RJ

更新日期：2002-03-21 00:00:00

abstract：:Conjugate (or 1,4-) additions of carbanionic species to α,β-unsaturated carbonyl compounds are vital to research in organic and medicinal chemistry, and there are several chiral catalysts that facilitate the catalytic enantioselective additions of nucleophiles to enoates. Nonetheless, catalytic enantioselective 1,6-co...

journal_title：Nature

authors： Meng F,Li X,Torker S,Shi Y,Shen X,Hoveyda AH

更新日期：2016-09-15 00:00:00

abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...

journal_title：Nature

authors： Acharya R,Fry E,Stuart D,Fox G,Rowlands D,Brown F

更新日期：1989-02-23 00:00:00

abstract：:Recognition of an avirulent pathogen triggers the rapid production of the reactive oxygen intermediates superoxide (O2-) and hydrogen peroxide (H2O2). This oxidative burst drives crosslinking of the cell wall, induces several plant genes involved in cellular protection and defence, and is necessary for the initiation ...

journal_title：Nature

authors： Delledonne M,Xia Y,Dixon RA,Lamb C

更新日期：1998-08-06 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

journal_title：Nature

authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

更新日期：2016-02-11 00:00:00

abstract：:Prostaglandins have wide-ranging effects in the body and are thought to be important mediators of inflammation. Cyclooxygenase (COX) plays a key regulatory role in prostaglandin synthesis, and occurs in both constitutive (COX-1) and inducible (COX-2) isoforms. COX-1 is thought to provide cytoprotective effects, wherea...

journal_title：Nature

authors： Dinchuk JE,Car BD,Focht RJ,Johnston JJ,Jaffee BD,Covington MB,Contel NR,Eng VM,Collins RJ,Czerniak PM

更新日期：1995-11-23 00:00:00

abstract：:Courtship is an innate sexually dimorphic behaviour that can be observed in naive animals without previous learning or experience, suggesting that the neural circuits that mediate this behaviour are developmentally programmed. In Drosophila, courtship involves a complex yet stereotyped array of dimorphic behaviours th...

journal_title：Nature

authors： Datta SR,Vasconcelos ML,Ruta V,Luo S,Wong A,Demir E,Flores J,Balonze K,Dickson BJ,Axel R

更新日期：2008-03-27 00:00:00

abstract：:Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...

journal_title：Nature

authors： Dodson HC,Walliker JR,Frampton S,Douek EE,Fourcin AJ,Bannister LH

更新日期：1986-03-06 00:00:00

abstract：:BINDING of the TATA-binding protein (TBP) to the TATA box is required for transcription from many eukaryotic promoters in gene expression. Regulation of this binding is therefore likely to be an important determinant of promoter activity. Incorporation of the TATA sequence into nucleosomes dramatically reduces transcr...

journal_title：Nature

authors： Imbalzano AN,Kwon H,Green MR,Kingston RE

更新日期：1994-08-11 00:00:00

abstract：:The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...

journal_title：Nature

authors： Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

更新日期：2020-07-01 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeats (CRISPR)-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA-DNA base-pairing to target foreign DNA in bacteria. Cas9-guide RNA complexes are also effective genome engineering agents in animals and plants. Here we use single-molecule and bulk...

journal_title：Nature

authors： Sternberg SH,Redding S,Jinek M,Greene EC,Doudna JA

更新日期：2014-03-06 00:00:00

abstract：:To identify cis-acting DNA elements involved in the activation of the alpha-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the...

journal_title：Nature

authors： Scott RW,Vogt TF,Croke ME,Tilghman SM

更新日期：1984-08-16 00:00:00

abstract：:Vasopressin (VP) potentiates the effect of corticotropin-releasing factor (CRF) on the secretion of adrenocorticotropic hormone (ACTH) from anterior pituitary cells in vitro, and both CRF and VP have been found in portal blood. These data support the hypothesis that VP acts synergistically with CRF to cause the secret...

journal_title：Nature

authors： Whitnall MH,Mezey E,Gainer H

更新日期：1985-09-19 00:00:00

abstract：:Some surprising facts about the most productive institutions emerge when Japanese life-science research is subject to a novel type of assessment. ...

journal_title：Nature

authors： Yamazaki S

更新日期：1994-11-10 00:00:00

abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...

journal_title：Nature

authors： Schlacher K,Cox MM,Woodgate R,Goodman MF

更新日期：2006-08-24 00:00:00

abstract：:A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt, couples photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate phototransduction cascade. The interactions of the Gt ...

journal_title：Nature

authors： Slep KC,Kercher MA,He W,Cowan CW,Wensel TG,Sigler PB

更新日期：2001-02-22 00:00:00

abstract：:Recent studies have shown that short chemically synthesized peptides very often induce antibodies which react with the cognate sequence in the intact folded protein. Since such antibodies react with known regions of proteins, they are of predetermined specificity and offer a precision not previously possible with immu...

journal_title：Nature

authors： Alexander H,Johnson DA,Rosen J,Jerabek L,Green N,Weissman IL,Lerner RA

更新日期：1983-12-15 00:00:00

abstract：:The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, ma...

journal_title：Nature

authors： Pabo CO,Lewis M

更新日期：1982-07-29 00:00:00

abstract：:Calcium (Ca(2+))-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remain...

journal_title：Nature

authors： Yang YD,Cho H,Koo JY,Tak MH,Cho Y,Shim WS,Park SP,Lee J,Lee B,Kim BM,Raouf R,Shin YK,Oh U

更新日期：2008-10-30 00:00:00

abstract：:The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mev...

journal_title：Nature

authors： Goldstein JL,Brown MS

更新日期：1990-02-01 00:00:00

abstract：:Maize smut caused by the fungus Ustilago maydis is a widespread disease characterized by the development of large plant tumours. U. maydis is a biotrophic pathogen that requires living plant tissue for its development and establishes an intimate interaction zone between fungal hyphae and the plant plasma membrane. U. ...

journal_title：Nature

authors： Djamei A,Schipper K,Rabe F,Ghosh A,Vincon V,Kahnt J,Osorio S,Tohge T,Fernie AR,Feussner I,Feussner K,Meinicke P,Stierhof YD,Schwarz H,Macek B,Mann M,Kahmann R

更新日期：2011-10-05 00:00:00

abstract：:Historically, the study of speech processing has emphasized a strong link between auditory perceptual input and motor production output. A kind of 'parity' is essential, as both perception- and production-based representations must form a unified interface to facilitate access to higher-order language processes such a...

journal_title：Nature

authors： Cogan GB,Thesen T,Carlson C,Doyle W,Devinsky O,Pesaran B

更新日期：2014-03-06 00:00:00

abstract：: ...

journal_title：Nature

authors： Kelly S,Carrington M

更新日期：2018-11-01 00:00:00