Abstract:
:The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
journal_name
Naturejournal_title
Natureauthors
Goldstein JL,Brown MSdoi
10.1038/343425a0subject
Has Abstractpub_date
1990-02-01 00:00:00pages
425-30issue
6257eissn
0028-0836issn
1476-4687journal_volume
343pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14183
更新日期:2015-02-26 00:00:00
abstract::Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2. The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0140-0
更新日期:2018-06-01 00:00:00
abstract::Multiple sclerosis is commonly associated with a local humoral immune response within the central nervous system. A hallmark of this intrathecal response is the presence of electrophoretically demonstrable oligoclonal bands of IgG in the cerebrospinal fluid (CSF) of up to 95% of patients. Observations indicating that ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338769a0
更新日期:1989-04-27 00:00:00
abstract::Epidermal growth factor (EGF) and transforming growth factor type I (TGF) are polypeptides of 53 and 50 amino acid residues, respectively. Both bind to EGF receptor, a 1,200-residue transmembranous glycoprotein, leading to phosphorylation of the receptor, enhancement of its tyrosine-specific kinase activity and ultima...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313491a0
更新日期:1985-02-07 00:00:00
abstract::In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285573a0
更新日期:1980-06-19 00:00:00
abstract::Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23276
更新日期:2017-08-10 00:00:00
abstract::Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal diffe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11661
更新日期:2013-01-10 00:00:00
abstract::Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon dioxide. Carbon's heavier homologues in group 14 of the periodic table--including silicon, germanium and t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01380
更新日期:2003-02-13 00:00:00
abstract::A statute banning nuclear weapons research in Cambridge, Massachusetts, is scheduled for a referendum vote in November 1983. If passed, the act would require the city to fine or imprison violators after the ban takes effect in October 1985, and could have an impact on work done at Harvard University and the Massachus...
journal_title:Nature
pub_type: 新闻
doi:10.1038/305173a0
更新日期:1983-09-15 00:00:00
abstract::The standard form of back-propagation learning is implausible as a model of perceptual learning because it requires an external teacher to specify the desired output of the network. We show how the external teacher can be replaced by internally derived teaching signals. These signals are generated by using the assumpt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355161a0
更新日期:1992-01-09 00:00:00
abstract::There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approxima...
journal_title:Nature
pub_type: 杂志文章,多中心研究
doi:10.1038/nature05911
更新日期:2007-06-07 00:00:00
abstract::In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process. Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding aden...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25174
更新日期:2018-01-18 00:00:00
abstract::Although male parental care is rare among mammals, adult males of many cercopithecine primate species provide care for infants and juveniles. This care is often in the form of grooming, carrying, support in agonistic interactions, and protection against infanticide. For these behaviours to be interpreted as true paren...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01866
更新日期:2003-09-11 00:00:00
abstract::Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/18872
更新日期:1999-04-01 00:00:00
abstract::Change history: In this Letter, the bottom blot in Fig. 2g (for 'IB: Myc') was missing. This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1360-7
更新日期:2019-07-01 00:00:00
abstract::The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06239
更新日期:2007-11-29 00:00:00
abstract::H-2 class I antigens appear to direct the recognition of virus-infected and neoplastic transformed cells by cytotoxic T lymphocytes (CTLs). Here, to identify the regions of class I antigens involved in CTL recognition, four hybrid class I genes were constructed in which exons were exchanged between the H-2Kb and H-2Db...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309279a0
更新日期:1984-05-17 00:00:00
abstract::Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11970
更新日期:2013-03-28 00:00:00
abstract::Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06468
更新日期:2008-01-10 00:00:00
abstract::This corrects the article DOI: 10.1038/nature18614. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/nature25991
更新日期:2018-03-21 00:00:00
abstract::NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01497
更新日期:2003-03-20 00:00:00
abstract::At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constitu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03029
更新日期:2004-12-23 00:00:00
abstract::During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35048555
更新日期:2000-12-14 00:00:00
abstract::The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/386569a0
更新日期:1997-04-10 00:00:00
abstract::Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low. Some evidence for the idea ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326405a0
更新日期:1987-03-26 00:00:00
abstract::The combination of complementary DNA expression and single-channel current analysis provides a powerful tool for studying the structure-function relationship of the nicotinic acetylcholine receptor (AChR) (refs 1-5). We have previously shown that AChR channels consisting of subunits from different species, expressed i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324670a0
更新日期:1986-12-18 00:00:00
abstract::The Tharsis region is the largest volcanic complex on Mars and in the Solar System. Young lava flows cover its surface (from the Amazonian period, less than 3 billion years ago) but its growth started during the Noachian era (more than 3.7 billion years ago). Its position has induced a reorientation of the planet with...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17171
更新日期:2016-03-17 00:00:00
abstract::The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion along...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35038090
更新日期:2000-10-19 00:00:00
abstract::In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290413a0
更新日期:1981-04-02 00:00:00
abstract::Using visual information to guide behaviour requires storage in a temporary buffer, known as visual short-term memory (VSTM), that sustains attended information across saccades and other visual interruptions. There is growing debate on whether VSTM capacity is limited to a fixed number of objects or whether it is vari...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04262
更新日期:2006-03-02 00:00:00