Abstract:
:This corrects the article DOI: 10.1038/nature18614.
journal_name
Naturejournal_title
Natureauthors
Reischauer S,Stone OA,Villasenor A,Chi N,Jin SW,Martin M,Lee MT,Fukuda N,Marass M,Witty A,Fiddes I,Kuo T,Chung WS,Salek S,Lerrigo R,Alsiö J,Luo S,Tworus D,Augustine SM,Mucenieks S,Nystedt B,Giraldez AJ,Schrothdoi
10.1038/nature25991subject
Has Abstractpub_date
2018-03-21 00:00:00pages
543issue
7697eissn
0028-0836issn
1476-4687pii
nature25991journal_volume
555pub_type
杂志文章,已发布勘误相关文献
NATURE文献大全abstract::Skeletal muscles consist of motor units which may differ considerably in contractile properties and types of usage. Some units participate mainly in relatively rare, quick movements and contract rapidly and are easily fatigued (type FF); others contribute to the maintenance of posture and hence contract slowly and are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314164a0
更新日期:1985-03-14 00:00:00
abstract::The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Until now there has been little evidence for native cardiac precursor cells in t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03215
更新日期:2005-02-10 00:00:00
abstract::Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335543a0
更新日期:1988-10-06 00:00:00
abstract::Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-l...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05945
更新日期:2007-08-02 00:00:00
abstract::D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375503a0
更新日期:1995-06-08 00:00:00
abstract::Many biomolecules are characterized by surfaces containing extended nonpolar regions, and the aggregation and subsequent removal of such surfaces from water is believed to play a critical role in the biomolecular assembly in cells. A better understanding of the hydrophobic hydration of biomolecules may therefore yield...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33653
更新日期:1998-04-16 00:00:00
abstract::X chromosomes evolve differently from autosomes, but general governing principles have not emerged. For example, genes with male-biased expression are under-represented on the X chromosome of D. melanogaster, but are randomly distributed in the genome of Anopheles gambiae. In direct global profiling experiments using ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06330
更新日期:2007-11-08 00:00:00
abstract::Insulin stimulates glucose uptake in muscle and adipocytes by signalling the translocation of GLUT4 glucose transporters from intracellular membranes to the cell surface. The translocation of GLUT4 may involve signalling pathways that are both independent of and dependent on phosphatidylinositol-3-OH kinase (PI(3)K). ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01246
更新日期:2002-12-19 00:00:00
abstract::During attempts to select nonsecretory variants from 0.467.3, and Epstein-Barr virus-transformed human lymphoblastoid cell line that secretes small amounts of IgM lambda, we exposed the cells to UV light. Cells that survived the irradiation were subcultured and their supernatants were screened for immunoglobulin produ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/306189a0
更新日期:1983-11-10 00:00:00
abstract::Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337557a0
更新日期:1989-02-09 00:00:00
abstract::The ability of mass spectrometry to generate intact biomolecular ions efficiently in the gas phase has led to its widespread application in metabolomics, proteomics, biological imaging, biomarker discovery and clinical assays (namely neonatal screens). Matrix-assisted laser desorption/ionization (MALDI) and electrospr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06195
更新日期:2007-10-25 00:00:00
abstract::It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313678a0
更新日期:1985-02-21 00:00:00
abstract::The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326689a0
更新日期:1987-04-16 00:00:00
abstract::Rac signalling to actin -- a pathway that is thought to be mediated by the protein Scar/WAVE (WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein -- has a principal role in cell motility. In an analogous pathway, direct interaction of Cdc42 with the related protein N-WASP stimulates actin polym...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00859
更新日期:2002-08-15 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-018-07165-8
更新日期:2018-11-01 00:00:00
abstract::The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288088a0
更新日期:1980-11-06 00:00:00
abstract::In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129 family of inbred strains, and markedly increases TGCT incidence in 129-Ter/Ter males. In 129-Ter/Ter mice, some of the r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03595
更新日期:2005-05-19 00:00:00
abstract::The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated through the intracellular effectors SMAD2 and SMAD3 (hereafter SMAD2/3), whose canonical function is to control the activity of target genes by interacting with transcriptiona...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25784
更新日期:2018-03-08 00:00:00
abstract::The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386177a0
更新日期:1997-03-13 00:00:00
abstract::The c-myc gene product is a nuclear protein expressed in a wide variety of cell types. It has been implicated in the control of normal cell growth as well as transformation, but its exact function is unknown. When the human promyelocytic leukaemia cell line HL60 is treated with retinoic acid, the cells differentiate i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321702a0
更新日期:1986-06-12 00:00:00
abstract::Human T-cell receptors for antigen and major histocompatibility complex (MHC) determinants have now been defined on inducer, suppressor, and class 1 and class 2 MHC-specific cytotoxic T lymphocytes as T3-associated clonotypic molecules (Ti) of relative molecular mass 90,000 (90K) composed of one 49-54K alpha- and one ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/312269a0
更新日期:1984-11-15 00:00:00
abstract::Myeloid precursors can be grown in vitro in the presence of specific growth factors; however, their expansion is limited by a competing process of terminal differentiation. Proto-oncogenes seem to be involved in cellular proliferation and/or differentiation and may also play a role in the myelopoietic process. Murine ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318667a0
更新日期:1985-12-19 00:00:00
abstract::The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature01400
更新日期:2003-01-23 00:00:00
abstract::The src gene product, p60src, of Rous sarcoma virus (RSV) is a tyrosine-specific protein kinase which is associated with the plasma membrane of infected cells. Myristic acid is bound in an amide linkage to glycine 2 of p60src. Of the N-terminal 30 kilodaltons of p60src, only amino acids 1-14 are required for myristyla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314374a0
更新日期:1985-03-28 00:00:00
abstract::The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12180
更新日期:2013-06-06 00:00:00
abstract::A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2228-6
更新日期:2020-06-01 00:00:00
abstract::Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic dri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2164-5
更新日期:2020-04-01 00:00:00
abstract::Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly reg...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/26500
更新日期:1998-09-24 00:00:00
abstract::The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378578a0
更新日期:1995-12-07 00:00:00
abstract::Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19067
更新日期:2016-08-18 00:00:00