Clathrate nanostructures for mass spectrometry.

abstract：:There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...

journal_title：Nature

authors： Bozovic I,Logvenov G,Verhoeven MA,Caputo P,Goldobin E,Geballe TH

更新日期：2003-04-24 00:00:00

abstract：:The fossil record of the living great apes is poor. New fossils from undocumented areas, particularly the equatorial forested habitats of extant hominoids, are therefore crucial for understanding their origins and evolution. Two main competing hypotheses have been proposed for orang-utan origins: dental similarities s...

journal_title：Nature

authors： Chaimanee Y,Suteethorn V,Jintasakul P,Vidthayanon C,Marandat B,Jaeger JJ

更新日期：2004-01-29 00:00:00

abstract：:The silicate Earth is strongly depleted in moderately volatile elements (such as lead, zinc, indium and alkali elements) relative to CI chondrites, the meteorites that compositionally most closely resemble the Sun. This depletion may be explained qualitatively by accretion of 10 to 20 per cent of a volatile-rich body ...

journal_title：Nature

authors： Norris CA,Wood BJ

更新日期：2017-09-27 00:00:00

abstract：:It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...

journal_title：Nature

authors： Cook DL,Hales CN

更新日期：1984-09-20 00:00:00

abstract：:The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described...

journal_title：Nature

authors： Varnum BC,Young C,Elliott G,Garcia A,Bartley TD,Fridell YW,Hunt RW,Trail G,Clogston C,Toso RJ

更新日期：1995-02-16 00:00:00

abstract：:Leprosy is a spectral disease in which immune responses to Mycobacterium leprae correlate with the clinical, bacteriological and histopathological manifestations of disease, so study of its pathology provides insights into immunoregulatory mechanisms in man. At the tuberculoid pole, patients have few lesions in the sk...

journal_title：Nature

authors： Modlin RL,Kato H,Mehra V,Nelson EE,Fan XD,Rea TH,Pattengale PK,Bloom BR

更新日期：1986-07-31 00:00:00

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The...

journal_title：Nature

authors： He Y,Zeng MY,Yang D,Motro B,Núñez G

更新日期：2016-02-18 00:00:00

abstract：:For hundreds of years, scientists have tracked the changing appearance of Mars, first by hand drawings and later by photographs. Because of this historical record, many classical albedo patterns have long been known to shift in appearance over time. Decadal variations of the martian surface albedo are generally attrib...

journal_title：Nature

authors： Fenton LK,Geissler PE,Haberle RM

更新日期：2007-04-05 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a...

journal_title：Nature

authors： Huxter J,Burgess N,O'Keefe J

更新日期：2003-10-23 00:00:00

abstract：:Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are common substances of abuse. Without reliable structural data, the mechanist...

journal_title：Nature

authors： Masiulis S,Desai R,Uchański T,Serna Martin I,Laverty D,Karia D,Malinauskas T,Zivanov J,Pardon E,Kotecha A,Steyaert J,Miller KW,Aricescu AR

更新日期：2019-01-01 00:00:00

abstract：:The human T-cell leukaemia and differentiation antigen HTA 1 is defined by the monoclonal antibody NA1/34 (ref. 1) and also recognized by the monoclonal antibody OKT6. Like class I products of the human major histocompatibility complex, it has a glycosylated heavy (alpha) chain of approximately 45-50,000 molecular wei...

journal_title：Nature

authors： Kefford RF,Calabi F,Fearnley IM,Burrone OR,Milstein C

更新日期：1984-04-12 00:00:00

abstract：:In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...

journal_title：Nature

authors： Belote JM,Lucchesi JC

更新日期：1980-06-19 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) detect and destroy cells displaying class I molecules of the major histocompatibility complex (MHC) that present oligopeptides derived from aberrant self or foreign proteins. Most class I peptide ligands are created from proteins that are degraded by proteasomes and transported, by the t...

journal_title：Nature

authors： Hanada K,Yewdell JW,Yang JC

更新日期：2004-01-15 00:00:00

abstract：:A long-sought goal in structural biology has been the imaging of membrane proteins in their membrane environments. This goal has been achieved with electron crystallography in those special cases where a protein forms highly ordered arrays in lipid bilayers. It has also been achieved by NMR methods in proteins up to 5...

journal_title：Nature

authors： Wang L,Sigworth FJ

更新日期：2009-09-10 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more tha...

journal_title：Nature

authors： Rice MC,O'Brien SJ

更新日期：1980-01-10 00:00:00

abstract：:Abscisic acid (ABA) is a vital phytohormone that regulates mainly stomatal aperture and seed development, but ABA receptors involved in these processes have yet to be determined. We previously identified from broad bean an ABA-binding protein (ABAR) potentially involved in stomatal signalling, the gene for which encod...

journal_title：Nature

authors： Shen YY,Wang XF,Wu FQ,Du SY,Cao Z,Shang Y,Wang XL,Peng CC,Yu XC,Zhu SY,Fan RC,Xu YH,Zhang DP

更新日期：2006-10-19 00:00:00

abstract：:Molecules capable of mimicking the function of a wide range of mechanical devices have been fabricated, with motors that can induce mechanical movement attracting particular attention. Such molecular motors convert light or chemical energy into directional rotary or linear motion, and are usually prepared and operated...

journal_title：Nature

authors： van Delden RA,ter Wiel MK,Pollard MM,Vicario J,Koumura N,Feringa BL

更新日期：2005-10-27 00:00:00

abstract：:Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an ep...

journal_title：Nature

authors： De Joussineau C,Soulé J,Martin M,Anguille C,Montcourrier P,Alexandre D

更新日期：2003-12-04 00:00:00

abstract：:Despite tremendous efforts, development of an effective vaccine against human immunodeficiency virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies have been identified that are capable of neutralizing most circulating HIV strains. These antibodies all exhibit an unusually high level of somat...

journal_title：Nature

authors： Balazs AB,Chen J,Hong CM,Rao DS,Yang L,Baltimore D

更新日期：2011-11-30 00:00:00

abstract：:Electrophoretic studies suggest that bacterial populations consist of a number of independent clones and that genetic recombination is rare in nature. But DNA sequencing reveals that individual bacterial genes have a mosaic structure that could have arisen only by recombination. How can these observations be reconcile...

journal_title：Nature

authors： Smith JM,Dowson CG,Spratt BG

更新日期：1991-01-03 00:00:00

abstract：:To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...

journal_title：Nature

authors： Gilbert MJ,Thornton CR,Wakley GE,Talbot NJ

更新日期：2006-03-23 00:00:00

abstract：:DNA methylation has a profound impact on genome stability, transcription and development. Although enzymes that catalyse DNA methylation have been well characterized, those that are involved in methyl group removal have remained elusive, until recently. The transformative discovery that ten-eleven translocation (TET) ...

journal_title：Nature

authors： Kohli RM,Zhang Y

更新日期：2013-10-24 00:00:00

abstract：:The response of the terrestrial carbon cycle to climate change is among the largest uncertainties affecting future climate change projections. The feedback between the terrestrial carbon cycle and climate is partly determined by changes in the turnover time of carbon in land ecosystems, which in turn is an ecosystem p...

journal_title：Nature

authors： Carvalhais N,Forkel M,Khomik M,Bellarby J,Jung M,Migliavacca M,Mu M,Saatchi S,Santoro M,Thurner M,Weber U,Ahrens B,Beer C,Cescatti A,Randerson JT,Reichstein M

更新日期：2014-10-09 00:00:00

abstract：:Spatially extended dynamical systems exhibit complex behaviour in both space and time--spatiotemporal chaos. Analysis of dynamical quantities (such as fractal dimensions and Lyapunov exponents) has provided insights into low-dimensional systems; but it has proven more difficult to understand spatiotemporal chaos in hi...

journal_title：Nature

authors： Egolf DA,Melnikov IV IV,Pesch W,Ecke RE

更新日期：2000-04-13 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-01-01 00:00:00

abstract：:Continental rifts are important sources of mantle carbon dioxide (CO2) emission into Earth's atmosphere1-3. Because deep carbon is stored for long periods in the lithospheric mantle4-6, rift CO2 flux depends on lithospheric processes that control melt and volatile transport1,3,7. The influence of compositional and thi...

journal_title：Nature

authors： Muirhead JD,Fischer TP,Oliva SJ,Laizer A,van Wijk J,Currie CA,Lee H,Judd EJ,Kazimoto E,Sano Y,Takahata N,Tiberi C,Foley SF,Dufek J,Reiss MC,Ebinger CJ

更新日期：2020-06-01 00:00:00