Nitrogen fixation gene (nifL) involved in oxygen regulation of nitrogenase synthesis in K. pneumoniae.

abstract：:The methylation of vertebrate DNA at the 5-position of approximately 3-10% of its cytosine residues occurs in a sequence-specific and tissue-specific manner and has been implicated in the control of transcription. How these differences are established and how they mediate the initiation or maintenance of transcription...

journal_title：Nature

authors： Huang LH,Wang R,Gama-Sosa MA,Shenoy S,Ehrlich M

更新日期：1984-03-15 00:00:00

abstract：:The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...

journal_title：Nature

authors： Noel JP,Hamm HE,Sigler PB

更新日期：1993-12-16 00:00:00

abstract：:The extent to which an organism is selected to invest in defences against pathogens and parasites depends on the advantages that ensue should infection occur, but also on the costs of maintaining defences in the absence of infection. The presence of heritable variation in resistance suggests that costs exist, but we k...

journal_title：Nature

authors： Kraaijeveld AR,Godfray HC

更新日期：1997-09-18 00:00:00

abstract：:Epstein-Barr virus (EBV), a member of the herpes group of viruses and the aetiological agent of infectious mononucleosis, is usually thought of as a lymphotrophic virus with the ability to transform B lymphocytes. So the association of EBV with nasopharyngeal carcinoma is puzzling, especially given the lack of success...

journal_title：Nature

authors： Sixbey JW,Vesterinen EH,Nedrud JG,Raab-Traub N,Walton LA,Pagano JS

更新日期：1983-12-01 00:00:00

abstract：:Two cytosolic fractions (A and B) from Xenopus oocytes are sufficient to support protein import into the nuclei of digitonin-permeabilized cells. Fraction A recognizes the nuclear localization sequence (NLS) and binds the import substrate to the nuclear envelope, whereas fraction B mediates the subsequent passage of t...

journal_title：Nature

authors： Moore MS,Blobel G

更新日期：1993-10-14 00:00:00

abstract：:Phase-dependent forms of microscopy (such as phase contrast, interference, or polarization microscopy) have been used for many years; the amount of phase retardation produces images based mainly on index of refraction. We have developed a microscope that forms images that depend on small differences in extinction for ...

journal_title：Nature

authors： Mickols W,Maestre MF,Tinoco I Jr

更新日期：1987-07-30 00:00:00

abstract：:Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...

journal_title：Nature

authors： Jones EY,Stuart DI,Walker NP

更新日期：1989-03-16 00:00:00

abstract：:The Borrmann effect-a dramatic increase in transparency to X-ray beams-is observed when X-rays satisfying Bragg's law diffract through a perfect crystal. The minimization of absorption seen in the Borrmann effect has been explained by noting that the electric field of the X-ray beam approaches zero amplitude at the cr...

journal_title：Nature

authors： Pettifer RF,Collins SP,Laundy D

更新日期：2008-07-10 00:00:00

abstract：:The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using molecular chaperone...

journal_title：Nature

authors： Shiber A,Döring K,Friedrich U,Klann K,Merker D,Zedan M,Tippmann F,Kramer G,Bukau B

更新日期：2018-09-01 00:00:00

abstract：:Water masers are found in dense molecular clouds closely associated with supermassive black holes at the centres of active galaxies. On the basis of the understanding of the local water-maser luminosity function, it was expected that masers at intermediate and high redshifts would be extremely rare. However, galaxies ...

journal_title：Nature

authors： Impellizzeri CM,McKean JP,Castangia P,Roy AL,Henkel C,Brunthaler A,Wucknitz O

更新日期：2008-12-18 00:00:00

abstract：:Modern agriculture has accelerated biological methane and nitrogen cycling on a global scale. Freshwater sediments often receive increased downward fluxes of nitrate from agricultural runoff and upward fluxes of methane generated by anaerobic decomposition. In theory, prokaryotes should be capable of using nitrate to ...

journal_title：Nature

authors： Raghoebarsing AA,Pol A,van de Pas-Schoonen KT,Smolders AJ,Ettwig KF,Rijpstra WI,Schouten S,Damsté JS,Op den Camp HJ,Jetten MS,Strous M

更新日期：2006-04-13 00:00:00

abstract：:Metabolic phenotypes are the products of interactions among a variety of factors-dietary, other lifestyle/environmental, gut microbial and genetic. We use a large-scale exploratory analytical approach to investigate metabolic phenotype variation across and within four human populations, based on 1H NMR spectroscopy. M...

journal_title：Nature

authors： Holmes E,Loo RL,Stamler J,Bictash M,Yap IK,Chan Q,Ebbels T,De Iorio M,Brown IJ,Veselkov KA,Daviglus ML,Kesteloot H,Ueshima H,Zhao L,Nicholson JK,Elliott P

更新日期：2008-05-15 00:00:00

abstract：:Growing populations and agricultural intensification have led to raised riverine nitrogen (N) loads, widespread oxygen depletion in coastal zones (coastal hypoxia)1 and increases in the incidence of algal blooms.Although recent work has suggested that individual wetlands have the potential to improve water quality2-9,...

journal_title：Nature

authors： Cheng FY,Van Meter KJ,Byrnes DK,Basu NB

更新日期：2020-12-01 00:00:00

abstract：:Since the discovery of superconductivity in the high-transition-temperature (high-T(c)) copper oxides two decades ago, it has been firmly established that the CuO(2) plane is essential for superconductivity and gives rise to a host of other very unusual properties. A new family of superconductors with the general comp...

journal_title：Nature

authors： Chen TY,Tesanovic Z,Liu RH,Chen XH,Chien CL

更新日期：2008-06-26 00:00:00

abstract：:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from D...

journal_title：Nature

authors： McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MA

更新日期：2002-07-04 00:00:00

abstract：:Large-conductance Ca(2+)-gated K(+) (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. This group of channels can be activated synergistically by both voltage and intracellular Ca(2+), with the large carboxy-terminal intracellular portion being res...

journal_title：Nature

authors： Wu Y,Yang Y,Ye S,Jiang Y

更新日期：2010-07-15 00:00:00

abstract：:A plasmalemmal Na(+)-Ca2+ exchange mechanism is an important electrogenic determinant of contractility in cardiac cells. As in other cell types, calcium influx by Na(+)-Ca2+ exchange is secondarily activated by cytoplasmic calcium and probably ATP, but these modulatory mechanisms are either absent or altered in isolat...

journal_title：Nature

authors： Hilgemann DW

更新日期：1990-03-15 00:00:00

abstract：:At fertilization, an increase of cytosolic calcium ions (Ca2+) triggers various activation responses in animal eggs. In vertebrates, these responses include exit from metaphase arrest in meiosis II (MII exit) and cortical remodelling initiated by cortical granule exocytosis. Although the essential requirement of Ca2+/...

journal_title：Nature

authors： Nishiyama T,Yoshizaki N,Kishimoto T,Ohsumi K

更新日期：2007-09-20 00:00:00

abstract：:Large low-velocity seismic anomalies have been detected in the Earth's lower mantle beneath Africa and the Pacific Ocean that are not easily explained by temperature variations alone. The African anomaly has been interpreted to be a northwest-southeast-trending structure with a sharp-edged linear, ridge-like morpholog...

journal_title：Nature

authors： McNamara AK,Zhong S

更新日期：2005-10-20 00:00:00

abstract：:A timescale is necessary for estimating rates of molecular and morphological change in organisms and for interpreting patterns of macroevolution and biogeography. Traditionally, these times have been obtained from the fossil record, where the earliest representatives of two lineages establish a minimum time of diverge...

journal_title：Nature

authors： Kumar S,Hedges SB

更新日期：1998-04-30 00:00:00

abstract：:The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leuk...

journal_title：Nature

authors： Mullighan CG,Miller CB,Radtke I,Phillips LA,Dalton J,Ma J,White D,Hughes TP,Le Beau MM,Pui CH,Relling MV,Shurtleff SA,Downing JR

更新日期：2008-05-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Glausiusz J

更新日期：2019-01-01 00:00:00

abstract：:Birds can perceive the reflectance of ultraviolet light by biological structures. Here we show that the skin of the mouth and body of starling nestlings substantially reflects light in the ultraviolet range and that young in which this reflectance is reduced will gain less mass than controls, despite low background le...

journal_title：Nature

authors： Jourdie V,Moureau B,Bennett AT,Heeb P

更新日期：2004-09-16 00:00:00

abstract：:Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedicine and the creation of 'intelligent' materials systems, for example as media for drug delivery, separation processes and protein imm...

journal_title：Nature

authors： Miyata T,Asami N,Uragami T

更新日期：1999-06-24 00:00:00

abstract：:The glyceraldehyde 3-phosphate dehydogenase holoenzyme of Bacillus stearothermophilus possesses precise 222 symmetry: in this respect it differs from the reported structure of the lobster muscle enzyme. Pairs of active sites are linked through a flexible polypeptide loop which probably mediates the structural changes ...

journal_title：Nature

authors： Biesecker G,Harris JI,Thierry JC,Walker JE,Wonacott AJ

更新日期：1977-03-24 00:00:00

abstract：:The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...

journal_title：Nature

authors： CHIME\/FRB Collaboration.

更新日期：2019-02-01 00:00:00

abstract：:Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extende...

journal_title：Nature

authors： Winter G,Milstein C

更新日期：1991-01-24 00:00:00

abstract：:The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions. The gene for protein S has been cloned and the DNA se...

journal_title：Nature

authors： Wistow G,Summers L,Blundell T

更新日期：1985-06-27 00:00:00

abstract：:For plants, the sensing of light in the environment is as important as vision is for animals. Fluctuations in light can be crucial to competition and survival. One way plants sense light is through the phytochromes, a small family of diverse photochromic protein photoreceptors whose origins have been traced to the pho...

journal_title：Nature

authors： Smith H

更新日期：2000-10-05 00:00:00

abstract：:Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3....

journal_title：Nature

authors： Welker F,Ramos-Madrigal J,Kuhlwilm M,Liao W,Gutenbrunner P,de Manuel M,Samodova D,Mackie M,Allentoft ME,Bacon AM,Collins MJ,Cox J,Lalueza-Fox C,Olsen JV,Demeter F,Wang W,Marques-Bonet T,Cappellini E

更新日期：2019-12-01 00:00:00