The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.

abstract：:During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...

journal_title：Nature

authors： O'Halloran T,Beckerle MC,Burridge K

更新日期：1985-10-03 00:00:00

abstract：:The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...

journal_title：Nature

authors： Taufiq-Ur-Rahman,Skupin A,Falcke M,Taylor CW

更新日期：2009-04-02 00:00:00

abstract：:Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substant...

journal_title：Nature

authors： Capron M,Capron A,Goetzl EJ,Austen KF

更新日期：1981-01-01 00:00:00

abstract：:Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...

journal_title：Nature

authors： Gundem G,Van Loo P,Kremeyer B,Alexandrov LB,Tubio JMC,Papaemmanuil E,Brewer DS,Kallio HML,Högnäs G,Annala M,Kivinummi K,Goody V,Latimer C,O'Meara S,Dawson KJ,Isaacs W,Emmert-Buck MR,Nykter M,Foster C,Kote-Jarai Z,

更新日期：2015-04-16 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:The maturation of RAS GTPases and approximately 200 other cellular CAAX proteins involves three enzymatic steps: addition of a farnesyl or geranylgeranyl prenyl lipid to the cysteine (C) in the C-terminal CAAX motif, proteolytic cleavage of the AAX residues and methylation of the exposed prenylcysteine residue at its ...

journal_title：Nature

authors： Diver MM,Pedi L,Koide A,Koide S,Long SB

更新日期：2018-01-25 00:00:00

abstract：:Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...

journal_title：Nature

authors： Primakoff P,Lathrop W,Woolman L,Cowan A,Myles D

更新日期：1988-10-06 00:00:00

abstract：:Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...

journal_title：Nature

authors： Trainor CD,Evans T,Felsenfeld G,Boguski MS

更新日期：1990-01-04 00:00:00

abstract：:The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in the cellular response to DNA damage. Although the p53 family members p63 and p73 are structurally related to p53, they have not been directly linked to tumour suppression, although they have been implicated in apoptosis. Given th...

journal_title：Nature

authors： Flores ER,Tsai KY,Crowley D,Sengupta S,Yang A,McKeon F,Jacks T

更新日期：2002-04-04 00:00:00

abstract：:gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian nervous system, is known to operate bicuculline-sensitive Cl- channels through GABAA receptors and bicuculline-insensitive cation channels through GABAB receptors. Recent observations indicate that the retina may contain GABA receptor...

journal_title：Nature

authors： Feigenspan A,Wässle H,Bormann J

更新日期：1993-01-14 00:00:00

abstract：:Atlantic tropical cyclone activity, as measured by annual storm counts, reached anomalous levels over the past decade. The short nature of the historical record and potential issues with its reliability in earlier decades, however, has prompted an ongoing debate regarding the reality and significance of the recent ris...

journal_title：Nature

authors： Mann ME,Woodruff JD,Donnelly JP,Zhang Z

更新日期：2009-08-13 00:00:00

abstract：:Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis. Abiraterone is metabolized in patients to Δ(4)-abiraterone (D4A), which has even greater anti-tumour activity and is structurally similar to e...

journal_title：Nature

authors： Li Z,Alyamani M,Li J,Rogacki K,Abazeed M,Upadhyay SK,Balk SP,Taplin ME,Auchus RJ,Sharifi N

更新日期：2016-05-26 00:00:00

abstract：:Knowledge of the composition of the Earth's core is important for understanding its melting point and therefore the temperature at the inner-core boundary and the temperature profile of the core and mantle. In addition, the partitioning of light elements between solid and liquid, as the outer core freezes at the inner...

journal_title：Nature

authors： Alfe D,Gillan MJ,Price GD

更新日期：2000-05-11 00:00:00

abstract：:The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain or...

journal_title：Nature

authors： Jones EY,Davis SJ,Williams AF,Harlos K,Stuart DI

更新日期：1992-11-19 00:00:00

abstract：:Fullerenes are graphitic cage structures incorporating exactly twelve pentagons. The smallest possible fullerene is thus C20, which consists solely of pentagons. But the extreme curvature and reactivity of this structure have led to doubts about its existence and stability. Although theoretical calculations have ident...

journal_title：Nature

authors： Prinzbach H,Weiler A,Landenberger P,Wahl F,Worth J,Scott LT,Gelmont M,Olevano D,v. Issendorff B

更新日期：2000-09-07 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is beta/A4 amyloid protein, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the beta/A4 amyloid protein precursor (APP)3. To test whethe...

journal_title：Nature

authors： Yoshikawa K,Aizawa T,Hayashi Y

更新日期：1992-09-03 00:00:00

abstract：:The population vector hypothesis was introduced almost twenty years ago to illustrate that a population vector constructed from neural activity in primary motor cortex (MI) of non-human primates could predict the direction of hand movement during reaching. Alternative explanations for this population signal have been ...

journal_title：Nature

authors： Scott SH,Gribble PL,Graham KM,Cabel DW

更新日期：2001-09-13 00:00:00

abstract：:Cation-selective P2X receptor channels were first described in sensory neurons where they are important for primary afferent neurotransmission and nociception. Here we report the cloning of a complementary DNA (P2X3) from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. We also found...

journal_title：Nature

authors： Lewis C,Neidhart S,Holy C,North RA,Buell G,Surprenant A

更新日期：1995-10-05 00:00:00

abstract：:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...

journal_title：Nature

authors： Walsh JJ,Christoffel DJ,Heifets BD,Ben-Dor GA,Selimbeyoglu A,Hung LW,Deisseroth K,Malenka RC

更新日期：2018-08-01 00:00:00

abstract：:Change history: In this Letter, the final two pages of the Supplementary Information, which included two tables listing primer and antibodies, respectively, were missing; see accompanying Amendment for the missing Supplementary Tables. This Letter has not been corrected online. ...

journal_title：Nature

authors： Wculek SK,Malanchi I

更新日期：2019-07-01 00:00:00

abstract：:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, c...

journal_title：Nature

authors： Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

更新日期：2004-02-19 00:00:00

abstract：:Sex in mammals is determined in the fetal gonad by the presence or absence of the Y chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicular Sertoli cells or ovarian granulosa cells. This pivotal decision in a single gonadal cell type ultimately controls sexual differentiat...

journal_title：Nature

authors： Matson CK,Murphy MW,Sarver AL,Griswold MD,Bardwell VJ,Zarkower D

更新日期：2011-07-20 00:00:00

abstract：:In the era of precision cosmology, it is essential to determine the Hubble constant empirically with an accuracy of one per cent or better1. At present, the uncertainty on this constant is dominated by the uncertainty in the calibration of the Cepheid period-luminosity relationship2,3 (also known as the Leavitt law). ...

journal_title：Nature

authors： Pietrzyński G,Graczyk D,Gallenne A,Gieren W,Thompson IB,Pilecki B,Karczmarek P,Górski M,Suchomska K,Taormina M,Zgirski B,Wielgórski P,Kołaczkowski Z,Konorski P,Villanova S,Nardetto N,Kervella P,Bresolin F,Kudritzki RP

更新日期：2019-03-01 00:00:00

abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...

journal_title：Nature

authors： Kocot KM,Cannon JT,Todt C,Citarella MR,Kohn AB,Meyer A,Santos SR,Schander C,Moroz LL,Lieb B,Halanych KM

更新日期：2011-09-04 00:00:00

abstract：:DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...

journal_title：Nature

authors： Dennis EJ,Dobosiewicz M,Jin X,Duvall LB,Hartman PS,Bargmann CI,Vosshall LB

更新日期：2018-10-01 00:00:00

abstract：:Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X...

journal_title：Nature

authors： Pan Y,Lloyd C,Zhou H,Dolich S,Deeds J,Gonzalo JA,Vath J,Gosselin M,Ma J,Dussault B,Woolf E,Alperin G,Culpepper J,Gutierrez-Ramos JC,Gearing D

更新日期：1997-06-05 00:00:00

abstract：:Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. This results in the nuclear translocation of freed NF-kappaB dimers and the activation...

journal_title：Nature

authors： Rothwarf DM,Zandi E,Natoli G,Karin M

更新日期：1998-09-17 00:00:00

abstract：:The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by no...

journal_title：Nature

authors： Paquet D,Kwart D,Chen A,Sproul A,Jacob S,Teo S,Olsen KM,Gregg A,Noggle S,Tessier-Lavigne M

更新日期：2016-05-05 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：:The disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally high blood glucose resulting from a relative deficiency of insulin. It affects about 2% of the world's population and treatment of diabetes and its complications are an increasing health-care burden. Genetic factors are...

journal_title：Nature

authors： Yamagata K,Oda N,Kaisaki PJ,Menzel S,Furuta H,Vaxillaire M,Southam L,Cox RD,Lathrop GM,Boriraj VV,Chen X,Cox NJ,Oda Y,Yano H,Le Beau MM,Yamada S,Nishigori H,Takeda J,Fajans SS,Hattersley AT,Iwasaki N,Hansen T,

更新日期：1996-12-05 00:00:00