Abstract:
:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.
journal_name
Naturejournal_title
Natureauthors
McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MAdoi
10.1038/418038akeywords:
subject
Has Abstractpub_date
2002-07-04 00:00:00pages
38-9issue
6893eissn
0028-0836issn
1476-4687pii
418038ajournal_volume
418pub_type
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