Abstract:
:The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described as a retroviral transforming gene, and c-Mer, encoded by a human proto-oncogene expressed in neoplastic B- and T-cell lines. The transforming activity of Axl demonstrates that the receptor can drive cellular proliferation. The function of Axl in non-transformed cells and tissues is unknown, but may involve the stimulation of cell proliferation in response to an appropriate signal, namely a ligand that activates the receptor. We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6). This is, to our knowledge, the first description of a ligand for the Axl family of receptors.
journal_name
Naturejournal_title
Natureauthors
Varnum BC,Young C,Elliott G,Garcia A,Bartley TD,Fridell YW,Hunt RW,Trail G,Clogston C,Toso RJdoi
10.1038/373623a0subject
Has Abstract,Author List Incompletepub_date
1995-02-16 00:00:00pages
623-6issue
6515eissn
0028-0836issn
1476-4687journal_volume
373pub_type
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