Worries about infectious cancer.

abstract：:In Fig. 3d this Letter, the R2 value should have been '0.19' instead of '0.66'; this has been corrected online. ...

journal_title：Nature

authors： Hoyt JR,Langwig KE,White JP,Kaarakka HM,Redell JA,Kurta A,DePue JE,Scullon WH,Parise KL,Foster JT,Frick WF,Kilpatrick AM

更新日期：2019-02-01 00:00:00

abstract：:DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...

journal_title：Nature

authors： Dennis EJ,Dobosiewicz M,Jin X,Duvall LB,Hartman PS,Bargmann CI,Vosshall LB

更新日期：2018-10-01 00:00:00

abstract：:Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...

journal_title：Nature

authors： CONVERGE consortium.

更新日期：2015-07-30 00:00:00

abstract：:The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...

journal_title：Nature

authors： Shakeel S,Rajendra E,Alcón P,O'Reilly F,Chorev DS,Maslen S,Degliesposti G,Russo CJ,He S,Hill CH,Skehel JM,Scheres SHW,Patel KJ,Rappsilber J,Robinson CV,Passmore LA

更新日期：2019-11-01 00:00:00

abstract：:Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metaz...

journal_title：Nature

authors： Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.

更新日期：2009-07-16 00:00:00

abstract：:Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...

journal_title：Nature

authors： Joshi PK,Esko T,Mattsson H,Eklund N,Gandin I,Nutile T,Jackson AU,Schurmann C,Smith AV,Zhang W,Okada Y,Stančáková A,Faul JD,Zhao W,Bartz TM,Concas MP,Franceschini N,Enroth S,Vitart V,Trompet S,Guo X,Chasman DI,

更新日期：2015-07-23 00:00:00

abstract：:Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mech...

journal_title：Nature

authors： Ekiert DC,Kashyap AK,Steel J,Rubrum A,Bhabha G,Khayat R,Lee JH,Dillon MA,O'Neil RE,Faynboym AM,Horowitz M,Horowitz L,Ward AB,Palese P,Webby R,Lerner RA,Bhatt RR,Wilson IA

更新日期：2012-09-27 00:00:00

abstract：:A soluble enzyme system has been discovered which specifically recognizes and replicates plasmids containing the Escherichia coli chromosomal origin, oriC. Electron microscopy has shown that plasmid replication begins at or near oriC from which it progresses bidirectionally to completion. Control of initiation of a cy...

journal_title：Nature

authors： Kaguni JM,Fuller RS,Kornberg A

更新日期：1982-04-15 00:00:00

abstract：:Cysticercosis caused by larval tapeworms is a major public health problem and a cause of substantial economic losses in the farm-animal industries. Taenia ovis in sheep is a particularly important example. Immunity to reinfection with the larvae has a central role in regulating natural transmission of the parasites, a...

journal_title：Nature

authors： Johnson KS,Harrison GB,Lightowlers MW,O'Hoy KL,Cougle WG,Dempster RP,Lawrence SB,Vinton JG,Heath DD,Rickard MD

更新日期：1989-04-13 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:When chemical reactions whose rate increases with the concentration of a product species are carried out in imperfectly mixed systems, a variety of complex behaviours can occur. These phenomena, which have relevance for biological processes as well, include chaotic and stochastic behaviour and selection of one final s...

journal_title：Nature

authors： Epstein IR

更新日期：1995-03-23 00:00:00

abstract：:Chromosome conformation capture methods have identified subchromosomal structures of higher-order chromatin interactions called topologically associated domains (TADs) that are separated from each other by boundary regions. By subdividing the genome into discrete regulatory units, TADs restrict the contacts that enhan...

journal_title：Nature

authors： Franke M,Ibrahim DM,Andrey G,Schwarzer W,Heinrich V,Schöpflin R,Kraft K,Kempfer R,Jerković I,Chan WL,Spielmann M,Timmermann B,Wittler L,Kurth I,Cambiaso P,Zuffardi O,Houge G,Lambie L,Brancati F,Pombo A,Vingron M,

更新日期：2016-10-13 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis and the cachexia associated with cancer or human immunodeficiency virus infection. TNF-alpha is initially expressed...

journal_title：Nature

authors： Gearing AJ,Beckett P,Christodoulou M,Churchill M,Clements J,Davidson AH,Drummond AH,Galloway WA,Gilbert R,Gordon JL

更新日期：1994-08-18 00:00:00

abstract：:DNA repair by homologous recombination is highly suppressed in G1 cells to ensure that mitotic recombination occurs solely between sister chromatids. Although many homologous recombination factors are cell-cycle regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G...

journal_title：Nature

authors： Orthwein A,Noordermeer SM,Wilson MD,Landry S,Enchev RI,Sherker A,Munro M,Pinder J,Salsman J,Dellaire G,Xia B,Peter M,Durocher D

更新日期：2015-12-17 00:00:00

abstract：:The opening and closing of voltage-activated Na+, Ca2+ and K+ (Kv) channels underlies electrical and chemical signalling throughout biology, yet the structural basis of voltage sensing is unknown. Hanatoxin is a tarantula toxin that inhibits Kv channels by binding to voltage-sensor paddles, crucial helix-turn-helix mo...

journal_title：Nature

authors： Phillips LR,Milescu M,Li-Smerin Y,Mindell JA,Kim JI,Swartz KJ

更新日期：2005-08-11 00:00:00

abstract：:The dopa analogue 6-fluorodopa (6-FD) used with positron emission tomography (PET) allows in vivo visualization of dopamine and its metabolites in nigrostriatal nerve endings. We have now found abnormal 6-FD scans in four subjects exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). None had parkinsonism. T...

journal_title：Nature

authors： Calne DB,Langston JW,Martin WR,Stoessl AJ,Ruth TJ,Adam MJ,Pate BD,Schulzer M

更新日期：1985-09-19 00:00:00

abstract：:Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...

journal_title：Nature

authors： Reisz RR,Huang TD,Roberts EM,Peng S,Sullivan C,Stein K,LeBlanc AR,Shieh D,Chang R,Chiang C,Yang C,Zhong S

更新日期：2013-04-11 00:00:00

abstract：:In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...

journal_title：Nature

authors： Haase SB,Reed SI

更新日期：1999-09-23 00:00:00

abstract：:Generalization is a cognitive ability that allows similar stimuli along a given dimension to be treated as equivalents. Insects exhibit high levels of visual generalization. Honeybees trained to recognize complex visual stimuli on the basis of a single feature generalize their choice to novel stimuli sharing that comm...

journal_title：Nature

authors： Stach S,Benard J,Giurfa M

更新日期：2004-06-17 00:00:00

abstract：:Neuromorphic computing draws inspiration from the brain to provide computing technology and architecture with the potential to drive the next wave of computer engineering1-13. Such brain-inspired computing also provides a promising platform for the development of artificial general intelligence14,15. However, unlike c...

journal_title：Nature

authors： Zhang Y,Qu P,Ji Y,Zhang W,Gao G,Wang G,Song S,Li G,Chen W,Zheng W,Chen F,Pei J,Zhao R,Zhao M,Shi L

更新日期：2020-10-01 00:00:00

abstract：:Seventeen hominoid fossils recovered from Pliocene strata at Aramis, Middle Awash, Ethiopia make up a series comprising dental, cranial and postcranial specimens dated to around 4.4 million years ago. When compared with Australopithecus afarensis and with modern and fossil apes the Aramis fossil hominids are recognize...

journal_title：Nature

authors： White TD,Suwa G,Asfaw B

更新日期：1994-09-22 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature22062. ...

journal_title：Nature

authors： Pritchard HD

更新日期：2017-10-26 00:00:00

abstract：:Oral administration of antigen is used to induce antigen-specific peripheral immune tolerance. As well as preventing systemic immune responses to ingested proteins, oral tolerance to autoantigens has also been used to suppress autoimmune diseases in animals and humans. Both active suppression and clonal anergy are sug...

journal_title：Nature

authors： Chen Y,Inobe J,Marks R,Gonnella P,Kuchroo VK,Weiner HL

更新日期：1995-07-13 00:00:00

abstract：:Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a si...

journal_title：Nature

authors： Moses K,Ellis MC,Rubin GM

更新日期：1989-08-17 00:00:00

abstract：:The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and...

journal_title：Nature

authors： Kamikouchi A,Inagaki HK,Effertz T,Hendrich O,Fiala A,Göpfert MC,Ito K

更新日期：2009-03-12 00:00:00

abstract：:Complexity in male sexual displays is widely appreciated but diversity in female mate choice has received little attention. Males of many species have sexual displays composed of multiple display traits, and females are thought to use these different traits in mate choice. Models of multiple display trait evolution su...

journal_title：Nature

authors： Coleman SW,Patricelli GL,Borgia G

更新日期：2004-04-15 00:00:00

abstract：:Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and a...

journal_title：Nature

authors： Ishikawa F,Miyazono K,Hellman U,Drexler H,Wernstedt C,Hagiwara K,Usuki K,Takaku F,Risau W,Heldin CH

更新日期：1989-04-13 00:00:00

abstract：:A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identif...

journal_title：Nature

authors： Beroukhim R,Mermel CH,Porter D,Wei G,Raychaudhuri S,Donovan J,Barretina J,Boehm JS,Dobson J,Urashima M,Mc Henry KT,Pinchback RM,Ligon AH,Cho YJ,Haery L,Greulich H,Reich M,Winckler W,Lawrence MS,Weir BA,Tanaka KE,

更新日期：2010-02-18 00:00:00

abstract：:Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, howev...

journal_title：Nature

authors： Carlson CM,Endrizzi BT,Wu J,Ding X,Weinreich MA,Walsh ER,Wani MA,Lingrel JB,Hogquist KA,Jameson SC

更新日期：2006-07-20 00:00:00

abstract：:Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana...

journal_title：Nature

authors： Schacherer J,Shapiro JA,Ruderfer DM,Kruglyak L

更新日期：2009-03-19 00:00:00