Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.

Abstract:

:Infertility resulting from a severe defect in sperm production affects 2% of men worldwide. Of these men with azoospermia, the absence of sperm in semen, one in eight carry de novo deletions for a specific region of the Y chromosome. A candidate gene for the Y-chromosome azoospermia factor (AZF) has been identified and named Deleted in Azoospermia (DAZ). Here we describe the cloning and characterization of the Drosophila gene boule, which is a homologue of DAZ. The two genes encode closely related proteins that contain a predicted RNA-binding motif, and both loci are expressed exclusively in the testis. Loss of boule function results in azoospermia; meiotic divisions are blocked, although limited spermatid differentiation occurs. Histological examination of boule testes with cell-cycle markers indicates that the primary defect is at the meiotic G2/M transition. These results support the hypothesis that DAZ is the human AZF, and indicate that Boule and DAZ have an essential meiotic function in fly and human spermatogenesis.

journal_name

Nature

journal_title

Nature

authors

Eberhart CG,Maines JZ,Wasserman SA

doi

10.1038/381783a0

subject

Has Abstract

pub_date

1996-06-27 00:00:00

pages

783-5

issue

6585

eissn

0028-0836

issn

1476-4687

journal_volume

381

pub_type

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