Abstract：
:An amino acid sequence analysis of the N-terminal immunoglobulin heavy and light chain variable regions (VH and VL) from 16 hybridoma proteins which bind phosphorylcholine as well as the complete sequence analysis of 9 of these VH regions is presented. There seem to be more VH regions participating in the phosphorylcholine response than can be encoded directly by germ-line VH gene segments. Moreover, the V regions from IgG antibodies are considerably more variable than those from their IgM counterparts. These observations raise the possibility that a somatic mechanism for V region diversification produces greater diversity in IgG than in IgM antibodies.
journal_name
Naturejournal_title
Natureauthors
Gearhart PJ,Johnson ND,Douglas R,Hood Ldoi
10.1038/291029a0subject
Has Abstractpub_date
1981-05-07 00:00:00pages
29-34issue
5810eissn
0028-0836issn
1476-4687journal_volume
291pub_type
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