Abstract:
:Attempts to inhibit the recognition of soluble antigens by T lymphocytes using antibodies specific for the antigen in question have been uniformally unsuccessful, in contrast to the observed specific inhibition of antibody generation by B cells. One exception is the unique situation whereby anti-hapten antisera inhibit the T-cell proliferative responses observed when hapten-specific T lymphocytes or clones are cultured with hapten-derivatized cells or proteins. The inability to inhibit T-cell functions by antigen-specific antibodies has been interpreted in several ways: (1) T cells possess a different repertoire from B cells; (2) the antibodies tested recognize epitopes present on the native antigen, whereas T cells recognize non-native (processed) structures; (3) the antigenic determinant(s) recognized by T cells on the surface of antigen presenting cells are either not accessible to antibodies, or are present in low amounts. The development of antigen-specific T-cell clones and monoclonal antibodies both specific for the same antigenic determinants now allows this question to be investigated definitively. Here, we report for the first time the specific inhibition of antigen-induced T-cell clone proliferation by a monoclonal antibody directed against the relevant soluble protein antigen.
journal_name
Naturejournal_title
Natureauthors
Corradin G,Engers HDdoi
10.1038/308547a0subject
Has Abstractpub_date
1984-04-05 00:00:00pages
547-8issue
5959eissn
0028-0836issn
1476-4687journal_volume
308pub_type
杂志文章相关文献
NATURE文献大全abstract::Quantum states of mechanical motion can be important resources for quantum information, metrology and studies of fundamental physics. Recent demonstrations of superconducting qubits coupled to acoustic resonators have opened up the possibility of performing quantum operations on macroscale motional modes1-3, which can...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0717-7
更新日期:2018-11-01 00:00:00
abstract::Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02789
更新日期:2004-08-05 00:00:00
abstract::To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415156a
更新日期:2002-01-10 00:00:00
abstract::The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism conv...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287396a0
更新日期:1980-10-02 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00028-w
更新日期:2019-01-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology1,2. The reciprocal interplay betwe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1130-6
更新日期:2019-05-01 00:00:00
abstract::An essential feature of the bacterial pathogen Salmonella spp. is its ability to enter cells that are normally non-phagocytic, such as those of the intestinal epithelium. The bacterium achieves entry by delivering effector proteins into the host-cell cytosol by means of a specialized protein-secretion system (termed t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/45829
更新日期:1999-09-16 00:00:00
abstract::The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15709
更新日期:2015-11-05 00:00:00
abstract::Coherent light sources can be used to manipulate the outcome of light-matter interactions by exploiting interference phenomena in the time and frequency domain. A powerful tool in this emerging field of 'quantum control' is the adaptive shaping of femtosecond laser pulses, resulting, for instance, in selective molecul...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35102037
更新日期:2001-11-01 00:00:00
abstract::Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12071
更新日期:2013-04-18 00:00:00
abstract::Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310138a0
更新日期:1984-07-12 00:00:00
abstract::The assimilation and mineralization of dissolved organic carbon (DOC) by marine bacterioplankton is a major process in the ocean carbon cycle. However, little information exists on the specific metabolic functions of participating bacteria and on whether individual taxa specialize on particular components of the marin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06513
更新日期:2008-02-07 00:00:00
abstract::Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2632-y
更新日期:2020-08-01 00:00:00
abstract::Many animals rely on an internal heading representation when navigating in varied environments1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the elli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1767-1
更新日期:2019-12-01 00:00:00
abstract::Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of reside...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/345495a0
更新日期:1990-06-07 00:00:00
abstract::Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24620
更新日期:2017-11-30 00:00:00
abstract::The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it remains unknown whether a mechanism exists that integrates these nucleic-acid-sensing systems. Here we sho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08512
更新日期:2009-11-05 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs are molecularly and functionally equivalent to blastocyst-derived embryonic stem (ES) cells. By comparing genetically identical mouse ES ce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09017
更新日期:2010-05-13 00:00:00
abstract::Viruses are the most abundant biological organisms of the world's oceans. Viral infections are a substantial source of mortality in a range of organisms-including autotrophic and heterotrophic plankton-but their impact on the deep ocean and benthic biosphere is completely unknown. Here we report that viral production ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07268
更新日期:2008-08-28 00:00:00
abstract::To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334530a0
更新日期:1988-08-11 00:00:00
abstract::Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/42491
更新日期:1997-06-05 00:00:00
abstract::The internal organization of eukaryotic cells into functionally specialized, membrane-delimited organelles of unique composition implies a need for active, regulated lipid transport. Phosphatidylserine (PS), for example, is synthesized in the endoplasmic reticulum and then preferentially associates--through mechanisms...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12430
更新日期:2013-09-12 00:00:00
abstract::Interactions of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny and subsequently for helper and cytotoxic functions of CD4+CD8- T lymphocytes. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp120. The residues...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339548a0
更新日期:1989-06-15 00:00:00
abstract::We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (10(2)-10(120)) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/366525a0
更新日期:1993-12-09 00:00:00
abstract::The Earth's mantle is isotopically heterogeneous on length scales ranging from centimetres to more than 10(4) kilometres. This heterogeneity originates from partial melt extraction and plate tectonic recycling, whereas stirring during mantle convection tends to reduce it. Here we show that mid-ocean ridge basalts from...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04582
更新日期:2006-03-09 00:00:00
abstract::In 1975-79, joint expeditions from Yale University and the Geological Survey of Pakistan (YGSP) recovered fossil lorisids in the Siwalik Group of Pakistan from four localities, spanning a period before 10 Myr ago to about 7 Myr ago. In three of the localities, only isolated teeth or fragments were found, whereas the f...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/289585a0
更新日期:1981-02-12 00:00:00
abstract::Osteoarthritis-the most common form of age-related degenerative whole-joint disease1-is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation and subchondral bone remodelling2,3. However, the molecular mechanisms that underlie the pathogenesis of osteoarthritis are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0920-1
更新日期:2019-02-01 00:00:00
abstract::In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alternative, PI(3)K-AKT-mTOR, pathway (which is ERK independent) or on modul...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13572
更新日期:2014-09-04 00:00:00
abstract::The mariner transposable element is a small member of the short inverted terminal repeat class thought to transpose through a DNA intermediate. Originally described in Drosophila mauritiana, it is now known in several species of the family Drosophilidae, and in a moth Hyalophora cecropia. Here I use primers designed t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362241a0
更新日期:1993-03-18 00:00:00
abstract::In the Northern Hemisphere, ozone levels in the troposphere have increased by 35 per cent over the past century, with detrimental impacts on forest and agricultural productivity, even when forest productivity has been stimulated by increased carbon dioxide levels. In addition to reducing productivity, increased tropos...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02047
更新日期:2003-10-16 00:00:00