Ion channels enable electrical communication in bacterial communities.


:The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially propagating waves of potassium. These waves result from a positive feedback loop, in which a metabolic trigger induces release of intracellular potassium, which in turn depolarizes neighbouring cells. Propagating through the biofilm, this wave of depolarization coordinates metabolic states among cells in the interior and periphery of the biofilm. Deletion of the potassium channel abolishes this response. As predicted by a mathematical model, we further show that spatial propagation can be hindered by specific genetic perturbations to potassium channel gating. Together, these results demonstrate a function for ion channels in bacterial biofilms, and provide a prokaryotic paradigm for active, long-range electrical signalling in cellular communities.






Prindle A,Liu J,Asally M,Ly S,Garcia-Ojalvo J,Süel GM




Has Abstract


2015-11-05 00:00:00
















  • Substantial reservoirs of molecular hydrogen in the debris disks around young stars.

    abstract::Circumstellar accretion disks transfer matter from molecular clouds to young stars and to the sites of planet formation. The disks observed around pre-main-sequence stars have properties consistent with those expected for the pre-solar nebula from which our own Solar System formed 4.5 Gyr ago. But the 'debris' disks t...


    pub_type: 杂志文章


    authors: Thi WF,Blake GA,van Dishoeck EF,van Zadelhoff GJ,Horn JM,Becklin EE,Mannings V,Sargent AI,van Den Ancker ME,Natta A

    更新日期:2001-01-04 00:00:00

  • The Earth's 'hum' is driven by ocean waves over the continental shelves.

    abstract::Observations show that the seismic normal modes of the Earth at frequencies near 10 mHz are excited at a nearly constant level in the absence of large earthquakes. This background level of excitation has been called the 'hum' of the Earth, and is equivalent to the maximum excitation from a magnitude 5.75 earthquake. I...


    pub_type: 杂志文章


    authors: Webb SC

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  • Multiple sclerosis enters a grey area.

    abstract:: ...


    pub_type: 评论,新闻


    authors: Pappalardo JL,Hafler DA

    更新日期:2019-02-01 00:00:00

  • Inositol 1,4,5-trisphosphate activates a channel from smooth muscle sarcoplasmic reticulum.

    abstract::Inositol 1,4,5-trisphosphate (InsP3) can initiate calcium release into the cytoplasm in a variety of cells. From experiments using permeabilized cells, membrane vesicles, and patch-clamp techniques, it has been suggested that InsP3 acts by directly opening calcium channels. Here, we show that InsP3 induced openings of...


    pub_type: 杂志文章


    authors: Ehrlich BE,Watras J

    更新日期:1988-12-08 00:00:00

  • The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs.

    abstract::In contrast to microRNAs and Piwi-associated RNAs, short interfering RNAs (siRNAs) are seemingly dispensable for host-directed gene regulation in Drosophila. This notion is based on the fact that mutants lacking the core siRNA-generating enzyme Dicer-2 or the predominant siRNA effector Argonaute 2 are viable, fertile ...


    pub_type: 杂志文章


    authors: Okamura K,Chung WJ,Ruby JG,Guo H,Bartel DP,Lai EC

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  • Regulation of endoplasmic reticulum turnover by selective autophagy.

    abstract::The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an i...


    pub_type: 杂志文章


    authors: Khaminets A,Heinrich T,Mari M,Grumati P,Huebner AK,Akutsu M,Liebmann L,Stolz A,Nietzsche S,Koch N,Mauthe M,Katona I,Qualmann B,Weis J,Reggiori F,Kurth I,Hübner CA,Dikic I

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  • Long-term potentiation of electrotonic coupling at mixed synapses.

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    pub_type: 杂志文章


    authors: Yang XD,Korn H,Faber DS

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  • Pathology: cancer cells compress intratumour vessels.

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    pub_type: 杂志文章


    authors: Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

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  • Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster.

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    pub_type: 杂志文章


    authors: Kraaijeveld AR,Godfray HC

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  • A 61-million-person experiment in social influence and political mobilization.

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    pub_type: 杂志文章,随机对照试验


    authors: Bond RM,Fariss CJ,Jones JJ,Kramer AD,Marlow C,Settle JE,Fowler JH

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  • Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli.

    abstract::Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may underlie a diversity of functions is by modulating the signal-to-noise ratio in subpopulations of mPFC ...


    pub_type: 杂志文章


    authors: Vander Weele CM,Siciliano CA,Matthews GA,Namburi P,Izadmehr EM,Espinel IC,Nieh EH,Schut EHS,Padilla-Coreano N,Burgos-Robles A,Chang CJ,Kimchi EY,Beyeler A,Wichmann R,Wildes CP,Tye KM

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  • Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra.

    abstract::Within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. In this...


    pub_type: 杂志文章


    authors: Nedergaard S,Bolam JP,Greenfield SA

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  • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.

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    pub_type: 杂志文章


    authors: Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

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  • Synapsin I bundles F-actin in a phosphorylation-dependent manner.

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    pub_type: 杂志文章


    authors: Bähler M,Greengard P

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  • Genetic information and life insurance.

    abstract::Genetic testing will become the future standard of medical care. Life insurers will also need access to genetic information if the insurance industry is to survive intact and if cover is to remain affordable. ...


    pub_type: 杂志文章


    authors: Pokorski RJ

    更新日期:1995-07-06 00:00:00

  • Quantum simulation of antiferromagnetic spin chains in an optical lattice.

    abstract::Understanding exotic forms of magnetism in quantum mechanical systems is a central goal of modern condensed matter physics, with implications for systems ranging from high-temperature superconductors to spintronic devices. Simulating magnetic materials in the vicinity of a quantum phase transition is computationally i...


    pub_type: 杂志文章


    authors: Simon J,Bakr WS,Ma R,Tai ME,Preiss PM,Greiner M

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  • Glutamate locally activates dendritic outputs of thalamic interneurons.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Springer TA,Kaufman JF,Terhorst C,Strominger JL

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  • Three-dimensional structure of a tubulin-motor-protein complex.

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    authors: Hoenger A,Sablin EP,Vale RD,Fletterick RJ,Milligan RA

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  • Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila.

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    pub_type: 杂志文章


    authors: De Joussineau C,Soulé J,Martin M,Anguille C,Montcourrier P,Alexandre D

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  • Insulin action impaired by deficiency of the G-protein subunit G ialpha2.

    abstract::Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficie...


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    authors: Moxham CM,Malbon CC

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  • Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino acids.

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    pub_type: 杂志文章


    authors: Alexander H,Johnson DA,Rosen J,Jerabek L,Green N,Weissman IL,Lerner RA

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  • Optical addressing of an individual erbium ion in silicon.

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    pub_type: 杂志文章


    authors: Yin C,Rancic M,de Boo GG,Stavrias N,McCallum JC,Sellars MJ,Rogge S

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  • T-cell recognition of antigen and the Ia molecule as a ternary complex.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Norris CA,Wood BJ

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    pub_type: 杂志文章


    authors: Blain S,Quéguiner B,Armand L,Belviso S,Bombled B,Bopp L,Bowie A,Brunet C,Brussaard C,Carlotti F,Christaki U,Corbière A,Durand I,Ebersbach F,Fuda JL,Garcia N,Gerringa L,Griffiths B,Guigue C,Guillerm C,Jacquet S,J

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  • MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.

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    pub_type: 杂志文章


    authors: Deverson EV,Gow IR,Coadwell WJ,Monaco JJ,Butcher GW,Howard JC

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  • Detection of ozone on Saturn's satellites Rhea and Dione.

    abstract::The satellites Rhea and Dione orbit within the magnetosphere of Saturn, where they are exposed to particle irradiation from trapped ions. A similar situation applies to the galilean moons Europa, Ganymede and Callisto, which reside within Jupiter's radiation belts. All of these satellites have surfaces rich in water i...


    pub_type: 杂志文章


    authors: Noll KS,Roush TL,Cruikshank DP,Johnson RE,Pendleton YJ

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    pub_type: 杂志文章


    authors: England SB,Nicholson LV,Johnson MA,Forrest SM,Love DR,Zubrzycka-Gaarn EE,Bulman DE,Harris JB,Davies KE

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  • Ecosystem resilience despite large-scale altered hydroclimatic conditions.

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    pub_type: 历史文章,杂志文章


    authors: Ponce Campos GE,Moran MS,Huete A,Zhang Y,Bresloff C,Huxman TE,Eamus D,Bosch DD,Buda AR,Gunter SA,Scalley TH,Kitchen SG,McClaran MP,McNab WH,Montoya DS,Morgan JA,Peters DP,Sadler EJ,Seyfried MS,Starks PJ

    更新日期:2013-02-21 00:00:00