Abstract：
:The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially propagating waves of potassium. These waves result from a positive feedback loop, in which a metabolic trigger induces release of intracellular potassium, which in turn depolarizes neighbouring cells. Propagating through the biofilm, this wave of depolarization coordinates metabolic states among cells in the interior and periphery of the biofilm. Deletion of the potassium channel abolishes this response. As predicted by a mathematical model, we further show that spatial propagation can be hindered by specific genetic perturbations to potassium channel gating. Together, these results demonstrate a function for ion channels in bacterial biofilms, and provide a prokaryotic paradigm for active, long-range electrical signalling in cellular communities.
journal_name
Naturejournal_title
Natureauthors
Prindle A,Liu J,Asally M,Ly S,Garcia-Ojalvo J,Süel GMdoi
10.1038/nature15709subject
Has Abstractpub_date
2015-11-05 00:00:00pages
59-63issue
7576eissn
0028-0836issn
1476-4687pii
nature15709journal_volume
527pub_type
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